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Hypoxia-inducible factor-1αin myocardial infarction

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World Journal of Cardiology 2024年第4期16卷 181-185页

作者： IvanaŠkrlec Sergey N Kolomeichuk faculty of dental medicine and health Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia Institute of Biology Karelia Research Center of Russian Academy of SciencesPetrozavodsk 185910Russia Laboratory for Genomics Proteomicsand MetabolomicsResearch Institute of Biomedicine and Biomedical TechnologiesTyumen State Medical UniversityTyumen 625023Russia

Hypoxia-inducible factor 1(HIF1)has a crucial function in the regulation of oxygen levels in mammalian cells,especially under hypoxic *** importance in cardiovascular diseases,particularly in cardiac ischemia,is because of its ability to alleviate cardiac *** oxygen-responsive subunit,HIF1α,plays a crucial role in this process,as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival,angiogenesis,and ***,HIF1αexpression induced reperfusion in the ischemic skeletal muscle,and hypoxic skin wounds in diabetic animal models showed reduced HIF1α*** expression of HIF1αhas been shown to reduce apoptosis and oxidative stress in cardiomyocytes during acute myocardial *** variations in HIF1αhave also been found to correlate with altered responses to ischemic cardiovascular *** addition,a link has been established between the circadian rhythm and hypoxic molecular signaling pathways,with HIF1αfunctioning as an oxygen sensor and circadian genes such as period circadian regulator 2 responding to changes in *** editorial analyzes the relationship between HIF1αand the circadian rhythm and highlights its significance in myocardial adaptation to *** the changes in molecular signaling pathways associated with diseases,specifically cardiovascular diseases,provides the opportunity for innovative therapeutic interventions,especially in low-oxygen environments such as myocardial infarction.

关键词： Cardiovascular pathologies Circadian genes Hypoxia-inducible factor 1 Hypoxia Gene-gene interaction

Therapeutic Perspectives of IL1 Family Members in Liver Diseases:An Update

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1186-1193页

作者： Ines Bilić Ćurčić Tomislav Kizivat Ana Petrović Robert Smolić Ashraf Tabll George Y.Wu Martina Smolić faculty of medicine osijek University of OsijekOsijekCroatia University Hospital osijek OsijekCroatia faculty of den-tal medicine and health osijek University of OsijekOsijekCroatia National Research Center GizaEgypt Egypt Center for Research and Regenerative medicine(ECRRM) CairoEgypt University of Connecticut health Center FarmingtonCTUSA

Interleukin(IL)1 superfamily members are a cornerstone of a variety of inflammatory processes occurring in various organs including the *** of acute and chronic liver diseases regardless of etiology depends on the stage of hepatocyte damage,the release of inflammatory cytokines and disturbances in gut ***1 cytokines and re-ceptors can have pro-or anti-inflammatory roles,even dual functionalities conditioned by the ***-oping novel therapeutic strategies to block the IL1/IL1R sign-aling pathways seems like a reasonable *** mode of action is now exploited by anakinra and canakinumab,which are used to treat different inflammatory illnesses,and studies in liver diseases are on the *** this mini review,we have focused on the IL1 superfamily members,given their cru-cial role in liver inflammation diseases,specifically discussing their potential role in developing new treatment strategies.

关键词： Interleukin 1 superfamily members Inflammation Acute liver dis-ease Chronic liver disease Therapy

Anabolic androgenic steroid-induced liver injury:An update

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World Journal of Gastroenterology 2022年第26期28卷 3071-3080页

作者： Ana Petrovic Sonja Vukadin Renata Sikora Kristina Bojanic Robert Smolic Davor Plavec George Y Wu Martina Smolic Department of Pharmacology and Biochemistry Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Pharmacology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of dental medicine Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of dental medicine Health Center Osijek-Baranja CountyOsijek 31000Croatia Department of Otorhinolaryngology Neurosurgery and RadiologyFaculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Biophysics and Radiology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Radiology Health Center Osijek-Baranja CountyOsijek 31000Croatia Research Department Srebrnjak Children's HospitalZagreb 10000Croatia Department of medicine Division of Gastrenterology/HepatologyUniversity of Connecticut Health CenterFarmingtonCT 06030United States

Anabolic androgenic steroids(AASs)are a group of molecules including endogenous testosterone and synthetic derivatives that have both androgenic and anabolic *** properties make them therapeutically beneficial in medical conditions such as ***,they are commonly bought illegally and misused for their anabolic,skeletal muscle building,and performanceenhancing *** and long-term use of AASs affects all organs,leading to cardiovascular,neurological,endocrine,gastrointestinal,renal,and hematologic *** is one of the major concerns regarding AASs treatment and *** and its derivatives have been most often shown to induce a specific form of cholestasis,peliosis hepatis,and hepatic benign and malignant *** is currently believed that mechanisms of pathogenesis of these disorders include disturbance of antioxidative factors,upregulation of bile acid synthesis,and induction of hepatocyte *** toxicity cases are treated with supportive measures and liver function normalizes with discontinuation of ***,some long-term consequences are ***-induced liver injury should be taken in consideration in patients with liver disorders,especially with the increasing unintentional ingestion of supplements containing *** this paper,we review the most current knowledge about AAS-associated adverse effects on the liver,and their clinical presentations,prevalence,and pathophysiological mechanisms.

关键词： Androgens Steroids Cholestasis Fibrosis Liver Chemical and drug induced liver injury

Noninvasive Fibrosis Assessment in Chronic Hepatitis C Infection: An Update

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1228-1238页

作者： Kristina Bojanic Mirta Sudaric Bogojevic Sonja Vukadin Renata Sikora Gordana Ivanac Nikola Raguz Lucic Martina Smolic Ashraf ATabll George YWu Robert Smolic faculty of dental medicine and health osijek Josip Juraj Strossmayer University of OsijekOsijekCroatia faculty of medicine osijek Josip Juraj Strossmayer University of OsijekOsijekCroatia health Center osijek-Baranja County OsijekCroatia Department of Biology Josip Juraj Strossmayer University of OsijekOsijekCroatia University Hospital Dubrava ZagrebCroatia School of medicine University of ZagrebZagrebCroatia Microbial Biotechnology Department Biotechnology Research InstituteNational Research CenterGizaEgypt Egypt Center for Research and Regenerative medicine(ECRRM) CairoEgypt University of Connecticut health Center FarmingtonCTUSA

Liver biopsy is historically the gold standard for liver fibrosis assessment of chronic hepatitis C ***,with the introduction and validation of noninvasive tests(NITs)to evaluate advanced fibrosis,and the direct-acting antiviral agents for treatment of chronic hepatitis C virus(HCV),the role of NITs have become even more *** is now need for longitudinal monitoring and elucidation of cutoff values for prediction of liver-related complication after sustained virological *** aim of this report is to provide a critical overview of the various NITs available for the assessment of liver fibrosis in HCV patients.

关键词： Hepatitis C virus Fibrosis Noninvasive serum fibrosis markers Transient elastography Shear wave elastography Magnetic resonance elastography Steatohepatitis

Hepatitis B and circadian rhythm of the liver

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World Journal of Gastroenterology 2022年第27期28卷 3282-3296页

作者： Ivana Skrlec Jasminka talapko Department of Biophysics Biologyand ChemistryFaculty of Dental Medicine and HealthJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthOsijek 31000Croatia

The circadian rhythm in humans is determined by the central clock located in the hypothalamus’s suprachiasmatic nucleus,and it synchronizes the peripheral clocks in other *** clock genes and clock-controlled genes exist in almost all cell *** have an essential role in many physiological processes,including lipid metabolism in the liver,regulation of the immune system,and the severity of *** addition,circadian rhythm genes can stimulate the immune response of host cells to virus *** B virus(HBV)infection is the leading cause of liver disease and liver cancer *** infection depends on the host cell,and hepatocyte circadian rhythm genes are associated with HBV replication,survival,and *** core circadian rhythm proteins,REV-ERB and brain and muscle ARNTL-like protein 1,have a crucial role in HBV replication in *** addition to influencing the virus’s life cycle,the circadian rhythm also affects the pharmacokinetics and efficacy of antiviral ***,it is vital to apply antiviral therapy at the appropriate time of day to reduce toxicity and improve the effectiveness of antiviral *** these reasons,understanding the role of the circadian rhythm in the regulation of HBV infection and host responses to the virus provides us with a new perspective of the interplay of the circadian rhythm and anti-HBV ***,this review emphasizes the importance of the circadian rhythm in HBV infection and the optimization of antiviral treatment based on the circadian rhythm-dependent immune response.

关键词： Circadian rhythm Clock genes Hepatitis B virus Immune system Liver

Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France faculty of dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type II,among others.

关键词： diseases den rigidity

Prevalence of posttraumatic stress disorder following acute coronary syndrome and clinical characteristics of patients referred to cardiac rehabilitation

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World Journal of Psychiatry 2023年第6期13卷 376-385页

作者： Ivana Sopek Merkaš Nenad Lakušić Zdenko Sonicki Barbara Koret Sandra Vuk Pisk Igor Filipčić Department of Cardiology Special Hospital for Medical Rehabilitation Krapinske TopliceKrapinske Toplice 49217Croatia Department of Clinical medicine Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Internal medicine Family Medicine and History of MedicineFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Medical Statistics Epidemiologyand Medical InformaticsSchool of Public Health Andrija StamparSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Psychiatry Clinic for Psychiatry“Sveti Ivan”Zagreb 10000Croatia Department of Psychiatry and Neurology Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Psychiatry and Psychological medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND Studies have demonstrated that patients who have experienced acute coronary syndrome(ACS)have an increased risk of developing posttraumatic stress disorder(PTSD)and experiencing worse survival outcomes than those who do not develop ***,the prevalence rates of PTSD following ACS vary widely across studies,and it is noteworthy that in most cases,the diagnosis of PTSD was based on self-report symptom questionnaires,rather than being established by ***,the individual characteristics of patients who develop PTSD after ACS can differ widely,making it difficult to identify any consistent patterns or predictors of the *** To investigate the prevalence of PTSD among a large sample of patients undergoing cardiac rehabilitation(CR)after ACS,as well as their characteristics in comparison to a control *** The participants of this study are patients who have experienced ACS with or without undergoing percutaneous coronary intervention and are enrolled in a 3-wk CR program at the largest CR center in Croatia,the Special Hospital for Medical Rehabilitation Krapinske *** recruitment for the study took place over the course of one year,from January 1,2022,to December 31,2022,with a total of 504 *** expected average follow-up period for patients included in the study is about 18 mo,and currently *** self-assessment questionnaire for PTSD criteria and clinical psychiatric interview,a group of patients with a PTSD diagnosis was *** the participants who do not have a PTSD diagnosis,patients who would match those with a PTSD diagnosis in terms of relevant clinical and medical stratification variables and during the same rehabilitation period were selected to enable comparability of the two *** A total of 507 patients who were enrolled in the CR program were approached to participate in the *** patients declined to participate in the *** screening PTSD

关键词： Cardiac rehabilitation Acute coronary syndrome Posttraumatic stress disorder Psychiatric interview Multidisciplinary team Cardiac biomarkers

Growing importance of urogenital candidiasis in individuals with diabetes:A narrative review

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World Journal of Diabetes 2022年第10期13卷 809-821页

作者： Jasminka talapko Tomislav Meštrović IvanaŠkrlec Laboratory for Microbiology Faculty of Dental Medicine and HealthJosip Juraj Strossmayer University of OsijekOsijek 31000Croatia University North University Centre VaraždinVaraždin 42000Croatia Institute for health Metrics and Evaluation Department for Health Metrics SciencesUniversity of Washington School of MedicineSeattleWashington 98195United States Department of Biophysics Biologyand ChemistryFaculty of Dental Medicine and HealthJ.J.Strossmayer University of OsijekOsijek 31000Croatia

Both diabetes and fungal infections contribute significantly to the global disease burden,with increasing trends seen in most developed and developing countries during recent *** is reflected in urogenital infections caused by Candida species that are becoming ever more pervasive in diabetic patients,particularly those that present with unsatisfactory glycemic *** addition,a relatively new group of anti-hyperglycemic drugs,known as sodium glucose cotransporter 2 inhibitors,has been linked with an increased risk for colonization of the urogenital region with Candida spp.,which can subsequently lead to an infectious *** this review paper,we have highlighted notable virulence factors of Candida species(with an emphasis on Candida albicans)and shown how the interplay of many pathophysiological factors can give rise to vulvovaginal candidiasis,potentially complicated with recurrences and dire pregnancy *** have also addressed an increased risk of candiduria and urinary tract infections caused by species of Candida in females and males with diabetes,further highlighting possible complications such as emphysematous cystitis as well as the risk for the development of balanitis and balanoposthitis in(primarily uncircumcised)*** a steadily increasing global burden of diabetes,urogenital mycotic infections will undoubtedly become more prevalent in the future;hence,there is a need for an evidence-based approach from both clinical and public health perspectives.

关键词： Balanitis Balanoposthitis Candida Candidiasis Diabetes Pregnancy Urogenital infections Vulvovaginitis

Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes

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World Journal of Clinical Cases 2023年第8期11卷 1669-1683页

作者： Tatjana Matijević Jasminka talapko Tomislav Meštrović Marijan Matijević Suzana Erić Ivan Erić IvanaŠkrlec Department of Dermatology and Venereology University Hospital Center OsijekOsijek 31000Croatia faculty of dental medicine and health Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia University Centre Varaždin University NorthVaraždin 42000Croatia Institute for health Metrics and Evaluation and the Department for health Metrics Sciences University of Washington School of MedicineSeattleWA 98195United States Department of Surgery National Memorial Hospital VukovarVukovar 32000Croatia faculty of medicine Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia Department of Radiotherapy and Oncology Clinical Hospital Center OsijekOsijek 31000Croatia Department of Surgery Osijek University Hospital CentreOsijek 31000Croatia

Diabetes mellitus,a chronic disease of metabolism,is characterized by a disordered production or cellular utilization of *** foot disease,which comprises the spectrum of infection,ulceration,and gangrene,is one of the most severe complications of diabetes and is the most common cause of hospitalization in diabetic *** aim of this study is to provide an evidence-based overview of diabetic foot *** to neuropathy,diabetic foot infections can occur in the form of ulcers and minor skin *** patients with diabetic foot ulcers,ischemia and infection are the main causes of non-healing ulcers and *** compromises the immune system of individuals with diabetes,leading to persistent inflammation and delayed wound *** addition,the treatment of diabetic foot infections is challenging due to difficulty in accurate identification of pathogenic microorganisms and the widespread issue of antimicrobial *** a further complicating factor,the warning signs and symptoms of diabetic foot problems can easily be *** associated with diabetic foot complications include peripheral arterial disease and osteomyelitis;accordingly,the risk of these complications in people with diabetes should be assessed *** antimicrobial agents represent the mainstay of treatment for diabetic foot infections,if peripheral arterial disease is present,revascularization should be considered to prevent limb amputation.A multidisciplinary approach to the prevention,diagnosis,and treatment of diabetic patients,including those with foot ulcers,is of the utmost importance to reduce the cost of treatment and avoid major adverse consequences such as amputation.

关键词： Diabetic foot Diabetes mellitus Foot ulcer Infection Peripheral arterial disease