Therapeutic Perspectives of IL1 Family Members in Liver Diseases:An Update
作者机构：Faculty of Medicine OsijekUniversity of OsijekOsijekCroatia University Hospital OsijekOsijekCroatia Faculty of Den-tal Medicine and Health OsijekUniversity of OsijekOsijekCroatia National Research CenterGizaEgypt Egypt Center for Research and Regenerative Medicine(ECRRM)CairoEgypt University of Connecticut Health CenterFarmingtonCTUSA
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2022年第10卷第6期
页 面：1186-1193页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Croatian Ministry of Science and Education dedicated to multi-institutional fund-ing of scientific activity at the J.J.Strossmayer University of Osijek Osijek Croatia grant number ZUP2018-90(to Ines Bilić Ćurčić)
主 题：Interleukin 1 superfamily members Inflammation Acute liver dis-ease Chronic liver disease Therapy
摘 要：Interleukin(IL)1 superfamily members are a cornerstone of a variety of inflammatory processes occurring in various organs including the *** of acute and chronic liver diseases regardless of etiology depends on the stage of hepatocyte damage,the release of inflammatory cytokines and disturbances in gut ***1 cytokines and re-ceptors can have pro-or anti-inflammatory roles,even dual functionalities conditioned by the ***-oping novel therapeutic strategies to block the IL1/IL1R sign-aling pathways seems like a reasonable *** mode of action is now exploited by anakinra and canakinumab,which are used to treat different inflammatory illnesses,and studies in liver diseases are on the *** this mini review,we have focused on the IL1 superfamily members,given their cru-cial role in liver inflammation diseases,specifically discussing their potential role in developing new treatment strategies.
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