Anabolic androgenic steroid-induced liver injury:An update
作者机构：Department of Pharmacology and BiochemistryFaculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of PharmacologyFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Dental MedicineFaculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Dental MedicineHealth Center Osijek-Baranja CountyOsijek 31000Croatia Department of OtorhinolaryngologyNeurosurgery and RadiologyFaculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Biophysics and RadiologyFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of RadiologyHealth Center Osijek-Baranja CountyOsijek 31000Croatia Research DepartmentSrebrnjak Children's HospitalZagreb 10000Croatia Department of MedicineDivision of Gastrenterology/HepatologyUniversity of Connecticut Health CenterFarmingtonCT 06030United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第26期
页 面：3071-3080页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Androgens Steroids Cholestasis Fibrosis Liver Chemical and drug induced liver injury
摘 要：Anabolic androgenic steroids(AASs)are a group of molecules including endogenous testosterone and synthetic derivatives that have both androgenic and anabolic *** properties make them therapeutically beneficial in medical conditions such as ***,they are commonly bought illegally and misused for their anabolic,skeletal muscle building,and performanceenhancing *** and long-term use of AASs affects all organs,leading to cardiovascular,neurological,endocrine,gastrointestinal,renal,and hematologic *** is one of the major concerns regarding AASs treatment and *** and its derivatives have been most often shown to induce a specific form of cholestasis,peliosis hepatis,and hepatic benign and malignant *** is currently believed that mechanisms of pathogenesis of these disorders include disturbance of antioxidative factors,upregulation of bile acid synthesis,and induction of hepatocyte *** toxicity cases are treated with supportive measures and liver function normalizes with discontinuation of ***,some long-term consequences are ***-induced liver injury should be taken in consideration in patients with liver disorders,especially with the increasing unintentional ingestion of supplements containing *** this paper,we review the most current knowledge about AAS-associated adverse effects on the liver,and their clinical presentations,prevalence,and pathophysiological mechanisms.
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