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Insulinoma after sleeve gastrectomy:A case report

World Journal of Clinical Cases 2022年第18期10卷 6227-6233页

作者： Miry Lobaton-Ginsberg Pilar Sotelo-González Claudia Ramirez-Renteria Fany Gabriela Juárez-Aguilar Aldo Ferreira-Hermosillo facultad de medicina Universidad Anáhuac México NorteMexico City 52786Mexico Servicio de Endocrinología Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSMexico City 06720Mexico Unidad de Investigación Médica en Enfermedades Endocrinas Instituto Mexicano del Seguro SocialMexico City 06720Mexico Servicio de Anatomía Patológica Hospital de Especialidades del Centro Médico Nacional Siglo XXIIMSSMexico City 06720Mexico

BACKGROUND Laparoscopic sleeve gastrectomy(LSG)has been proposed as an effective and durable treatment for severe obesity and glucose metabolism disorders,and its prevalence has increased from 5%to 37%since *** common complication after bariatric surgery is a postprandial hyperinsulinemic hypoglycemic *** rare,insulinomas can cause this state,where symptoms are more common in the fasting state;thus,evaluation of insulin secretion is *** now,there have been no reports of insulinoma after *** SUMMARY We describe the case of a 43-year-old woman who was referred to the obesity clinic 2 years after LSG was *** had symptoms of hypoglycemia predominantly in the fasting state and documented hypoglycemia of less than 30 mg/d L,which are compatible with Whipple’s ***,dumping syndrome was suspected,but after a second low fasting plasma glucose was documented,a 72-h fasting test was performed that tested *** tomography and endoscopic ultrasound were performed,identifying the presence of a homogeneous hypoechoic semioval tumoral lesion in the *** diagnosis was compatible with *** laparoscopic enucleation of the insulinoma,the symptoms and hypoglycemia *** histopathological report described a well-differentiated grade 2 neuroendocrine tumor with positive chromogranin and synaptophysin and Ki67 immunopositivity in 4%of the neoplastic *** Insulinoma after LSG is a rare condition,and clinicians must be aware of it,especially if the patient has hypoglycemic symptoms during the fasting state.

关键词： Insulinoma Hypoglycemia Bariatric surgery Glucagon-like peptide 1 amide Neuroendocrine tumors Case report

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Ketamine effect on intracellular and mitochondrial calcium mobilization

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BIOCELL 2016年第1期40卷 11-14页

作者： JUANITA BUSTAMANTE ANALIA CZERNICZYNIEC SILVIA LORES-ARNAIZ Centro de Altos Estudios en Ciencias Humanas y de la Salud(CAECIHS) Facultad de MedicinaUniversidad Abierta InteramericanaBuenos AiresArgentina Instituto de Bioquímica y medicina Molecular Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresArgentina

The suppressive effects of ketamine on intracellular calcium has been reported in a variety of cells although the mechanisms involved are not well *** aim of this work was to evaluate the ketamine effect on the mitochondrial Ca^(2+)accumulation and the cellular Ca^(2+)mobilization using FLUO4-AM and flow *** results showed that mitochondria from ketamine injected animals presented a lower ability to retain calcium at concentrations higher than 20μM,as compared with controls(saline injected animals).In ad-dition,ketamine showed a significant decreased KCl-induced intracellular calcium *** increased calcium influx through cellular *** to the data presented herein,ketamine presents a clear inhibitory effect on cytosolic Ca2+transport mechanisms,independently from their action on the calcium channel associated NMDA receptor.

关键词： calcium transport hippocampal mitochondria Vero cell culture

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Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke

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Neural Regeneration Research 2021年第3期16卷 433-439页

作者： Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.López-Valdés División de Investigación Facultad de MedicinaUniversidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Laboratorio Experimental de Enfermedades Neurodegenerativas Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico departamento de Investigación Básica Instituto Nacional de GeriatríaCiudad de MéxicoMéxico Unidad de Investigación en Biología de la Reproducción Laboratorio de NeuroendocrinologíaFacultad de Estudios Superiores ZaragozaUNAMCiudad de MéxicoMéxico Unidad Periférica de Neurociencia Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the *** this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their *** currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these *** is an approved drug for the treatment of Alzheimer's *** is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate *** has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical *** present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients.

关键词： focal ischemic stroke memantine neuroplasticity neuroprotection stroke therapy

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Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine

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Genes & Diseases 2022年第4期9卷 928-940页

作者： dennis Cerrato-Izaguirre Yolanda I.Chirino Claudia M.García-Cuellar Miguel Santibáñez-Andrade Diddier Prada Angélica Hernández-Guerrero Octavio Alonso Larraga Javier Camacho Yesennia Sánchez-Pérez Subdirección de Investigación Básica Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico departamento de Farmacología Centro de Investigación y de Estudios Avanzados del I.P.N.(CINVESTAV)Ciudad de MéxicoCP 07360Mexico Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoLos Reyes IztacalaTlalnepantla de BazEstado de MéxicoCP 54090Mexico departamento de Informática Biomédica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacánCiudad de MéxicoCP 04510Mexico department of Environmental Health Science Mailman School of Public HealthColumbia UniversityNew YorkNY 10027USA Servicio de Endoscopía Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico

Latin-America (LATAM) is the second region in gastric cancer incidence;gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAM, and analyze how this landscape can be applied for precision medicine. We found that Brazil, Chile, Colombia, Mexico, Peru, and Venezuela are the countries with more published studies from LATAM explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the CDH1 gene have been identified for hereditary GA in Brazilian, Chilean, Colombian, and Mexican populations. An increased risk of developing somatic GA is associated with the following germline risk variants: IL-4, IL-8, TNF-α, PTGS2, NFKB1, RAF1, KRAS and MAPK1 in Brazilian;IL-10 in Chilean;IL-10 in Colombian;EGFR and ERRB2 in Mexican, TCF7L2 and Chr8q24 in Venezuelan population. The path from mutational landscape to precision medicine requires four development levels: 1) Data compilation, 2) Data analysis and integration, 3) development and approval of clinical approaches, and 4) Population benefits. Generating local genomic information is the initial padlock to overcome to generate and apply precision medicine.

关键词： Ethnicities Genome Latin America Mutati on Precisi on medicine Stomach neoplasms

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Evaluation of curcumin and copper acetate against Salmonella Typhimurium infection,intestinal permeability,and cecal microbiota composition in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1019-1030页

作者： Anaisa ALeyva-Diaz Daniel Hernandez-Patlan Bruno Solis-Cruz Bishnu Adhikari Young Min Kwon Juan D.Latorre Xochitl Hernandez-Velasco Benjamin Fuente-Martinez Billy M.Hargis Raquel Lopez-Arellano Guillermo Tellez-Isaias departamento de medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y ZootecniaUNAM04510 Ciudad de MexicoMexico Laboratorio 5:LEdeFAR Unidad de Investigacion MultidisciplinariaFacultad de Estudios Superiores(FES)CuautitlanUniversidad Nacional Autonoma de Mexico(UNAM)54714 Cuautitlan IzcalliMexico department of Poultry Science Center of Excellence for Poultry ScienceUniversity of Arkansas1260 W.MaplePOSC 0-114FayettevilleAR 72704USA Centro de Ensenanza Investigacion y Extension en Produccion AvicolaFacultad de Medicina Veterinaria y ZootecniaUNAMCiudad de MexicoMexico

Background:Interest in the use of natural feed additives as an alternative to antimicrobials in the poultry industry has increased in recent years because of the risk of bacterial *** of the most studied groups are polyphenolic compounds,given their advantages over other types of additives and their easy potentiation of effects when complexes are formed with metal ***,the objective of the present study was to evaluate the impact of dietary supplementation of copper acetate(CA),curcumin(CR),and their combination(CA-CR)against Salmonella Typhimurium colonization,intestinal permeability,and cecal microbiota composition in broiler chickens through a laboratory Salmonella infection *** recovery was determined on day 10 post-challenge by isolating Salmonella in homogenates of the right cecal tonsil(12 chickens per group)on Xylose Lysine Tergitol-4(XLT-4)with novobiocin and nalidixic *** integrity was indirectly determined by the fluorometric measurement of fluorescein isothiocyanate dextran(FITC-d)in serum samples from blood obtained on d 10 *** ***,microbiota analysis was performed using the content of the left caecal tonsil of 5 chickens per group by sequencing V4 region of 16S rRNA ***:The results showed that in two independent studies,all experimental treatments were able to significantly reduce the *** colonization in cecal tonsils(CT,Pdependent ***,the serum fluorescein isothiocyanate dextran(FITC-d)concentration in chickens treated with CR was significantly lower when compared to PC(P=0.0084),which is related to a decrease in intestinal permeability and therefore intestinal *** effect of dietary treatments in reducing Salmonella was further supported by the analysis of 16S rRNA gene sequences using Li

关键词： Broiler chickens Copper acetate Curcumin Intestinal permeability Microbiota composition Salmonella Typhimurium

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Role of microglial cells in photoreceptor degeneration

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Neural Regeneration Research 2019年第7期14卷 1186-1190页

作者： Johnny Di Pierdomenico Diego García-Ayuso Marta Agudo-Barriuso Manuel Vidal-Sanz María Paz Villegas-Pérez departamento de Oftalmología Facultad de MedicinaUniversidad de Murciaand Instituto Murciano de Investigación Biosanitaria Hospital Virgen de la Arrixaca(IMIB-Virgen de la Arrixaca)

Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the *** comprise various diseases,but retinitis pigmentosa is the most frequently *** pigmentosa is commonly limited to the eye,where there is progressive photoreceptor degeneration,rods and secondarily *** mechanisms of cone and rod degeneration continue to be investigated,since most of the mutations causing retinitis pigmentosa affect rods and thus,the secondary death of cones is an intriguing question but,ultimately,the cause of *** the mechanisms of rod and cone degeneration could help us to develop therapies to stop or,at least,slow down the degeneration *** cone degeneration has been attributed to the trophic dependence between rods and cones,but microglial cell activation could also have a *** this review,based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa,we show that microglial cell activation is observed prior to the the initiation of photoreceptor *** also show that there is an increase of the retinal microglial cell densities and invasion of the outer retinal layers by microglial *** inhibition of the microglial cells improves photoreceptor survival and morphology,documenting a role for microglial cells in photoreceptor ***,these results indicate that the modulation of microglial cell reactivity can be used to prevent or diminish photoreceptor death in inherited photoreceptor degenerations.

关键词： Royal College of Surgeons RCS P23H-1 microglia minocycline photoreceptor retinal degeneration retinitis pigmentosa

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ADAM17/TACE:a key molecule in brain injury regeneration

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Neural Regeneration Research 2019年第8期14卷 1378-1379页

作者： Samuel Dominguez-Garcia Carmen Castro Noelia Geribaldi-Doldan Area de Fisiologia Facultad de Medicina Universidad de Cadiz Cadiz Spain Instituto de Investigacion e Innovacion Biomedica de Cadiz (INIBICA) Universidad de Cadiz Cadiz Spain

It has been many years since "the tumor necrosis factor-a-converting enzyme”,also known as ADAM17/TACE, was described as "the enzyme that does it all” because of its role in neurodegenerative diseases and in several physiological processes including proteolysis, adhesion, intracellular signaling, migration and proliferation. ADAM17/TACE is an integral membrane protein that belongs to the disintegrin and metalloprotease (ADAM) family. Several years ago, Romero-Grimaldi et al.

关键词： ADAM17/TACE key molecule injury regeneration

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Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm:A potential therapeutic opportunity?

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Genes & Diseases 2023年第3期10卷 639-642页

作者： Lídia Puertas-Umbert Saray Varona Carme Ballester-Servera Judith Alonso Silvia Aguiló Mar Orriols Ernesto Martínez-Martínez Antonio Rodríguez-Sinovas JoséMartínez-González Cristina Rodríguez Institut de Recerca Hospital de la Santa Creu i Sant Pau(IRHSCSP) Barcelona 08025Spain Instituto de Investigación Biomédica Sant Pau Barcelona 08036Spain CIBER de Enfermedades Cardiovasculares ISCIIIMadrid 28029Spain Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas(IIBB-CSIC) Barcelona 08036Spain facultad de medicina Universidad Complutense de MadridInstituto de Investigación Sanitaria Gregorio MarañónMadrid 28040Spain Cardiovascular Diseases Research Group Vall d’Hebron Institut de RecercaVall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain

Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease with a prevalence up to 8% in males over 60 years of age.1 This is a complex disorder characterized by permanent and focal dilation of abdominal aorta that exceeds at least 50% of the normal diameter. In these patients, the aortic diameter progressively expands boosted by smoking and aging as major risk factors. Unfortunately, aneurysm growth increases the risk of aortic rupture, a life-threatening emergency that carries a mortality rate of 80%. despite the increasing effort of the scientific community to identify therapeutic strategies for AAA, there are currently no pharmacological tools that ameliorate aneurysm expansion, while the underlying mechanisms involved in this disease are not completely understood.

关键词： aneurysm aortic therapeutic

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Diabetic nephropathy,autophagy and proximal tubule protein endocytic transport:A potentially harmful relationship

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BIOCELL 2018年第2期42卷 35-40页

作者： Maximiliano GIRAUD-BILLOUD Claudio M.FAdeR Rocío AGÜERO Fernando EZQUER Marcelo EZQUER IHEM Universidad Nacional de CuyoCONICETMendozaArgentina Universidad Nacional de Cuyo Facultad de Ciencias MédicasInstituto de FisiologíaCasilla de Correo 335500-MendozaArgentina Universidad Nacional de Cuyo Facultad de OdontologíaCasilla de Correo 335500-MendozaArgentina Centro de medicina Regenerativa Facultad de Medicina Clínica AlemanaUniversidad del DesarrolloAvenida Las Condes 12438SantiagoChile

Diabetic nephropathy(DN)is the most frequent cause of chronic renal *** now,the pathophysiological mechanisms that determine its development and progression have not yet been *** the present study,we evaluate the role of autophagy at early stages of DN,induced in type 2 diabetes mellitus(T2DM)mouse,and its association with proximal tubule membrane endocytic receptors,megalin and *** T2DM animals we observed a tubule-interstitial injury with significantly increased levels of urinary GGT and ALP,but an absence of tubulointerstitial *** proximal tubule cells of T2DM animals showed autophagic vesicles larger than those observed in the control group,and an increase in the number of these vesicles marked with LBPA by ***,a significant decrease in the ratio of LC3II/LC3I isoforms and in p62 protein expression in DN affected animals is ***,we observed a marked increase in urinary albumin and vitamin D binding-protein levels in T2DM animals as well as a significant decrease in expression of megalin in the renal *** results indicate an alteration of the tubular endocytic transporters in DN,which could be related to autophagic dysfunction,which would in turn result in impaired organelle recycling,thus contributing to the progression of this disease.

关键词： Megalin Cubilin Type 2 diabetes mellitus

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Retinal remodeling following photoreceptor degeneration causes retinal ganglion cell death

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Neural Regeneration Research 2018年第11期13卷 1885-1886页

作者： Diego Garcia-Ayuso Johnny Di Pierdomenico Marta Agudo-Barriuso Manuel Vidal-Sanz Maria P. ViUegas-Perez departamento de Oftalmologla Facultad de Medicina Universidad de Murcia and Instituto Murciano de Investigacion Biosanitaria Hospital Virgen de la Arrixaca (IMIB-Virgen de la Arrixaca) Murcia Spain

The retina is the extension of the central nervous system that senses *** and rods,situated in the outer retina,convert light into electrical signals that travel through intermediate neurons where these are further pr... 详细信息

关键词： COMPRESSION VESSELS

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