Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm:A potential therapeutic opportunity?

作     者：Lídia Puertas-Umbert Saray Varona Carme Ballester-Servera Judith Alonso Silvia Aguiló Mar Orriols Ernesto Martínez-Martínez Antonio Rodríguez-Sinovas JoséMartínez-González Cristina Rodríguez Lídia Puertas-Umbert;Saray Varona;Carme Ballester-Servera;Judith Alonso;Silvia Aguiló;Mar Orriols;Ernesto Martínez-Martínez;Antonio Rodríguez-Sinovas;José Martínez-González;Cristina Rodríguez

作者机构：Institut de Recerca Hospital de la Santa Creu i Sant Pau(IRHSCSP)Barcelona 08025Spain Instituto de Investigación Biomédica Sant PauBarcelona 08036Spain CIBER de Enfermedades CardiovascularesISCIIIMadrid 28029Spain Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas(IIBB-CSIC)Barcelona 08036Spain Facultad de MedicinaUniversidad Complutense de MadridInstituto de Investigación Sanitaria Gregorio MarañónMadrid 28040Spain Cardiovascular Diseases Research GroupVall d’Hebron Institut de RecercaVall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第3期

页      面：639-642页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by Instituto de Salud CarlosⅢ(ISCⅢ)(No.PI21/01048,PI20/01649) the European Regional Development Fund(ERDF-FEDER,a way to build Europe),Ministerio de Ciencia e Innovacion(No.RTI2018-094727-B-100),AGAUR(No.2017-SGR-00333,2017-SGR-1807) Consejo Superior de Investigaciones Cientificas(No.2021AEP073) L.P.is supported by a PFIS contract(ISCⅢ) C.B-S by a FPU fellowship and A.R.-S.and M.G.were funded by the Miguel Servet Program 

主　　题：aneurysm aortic therapeutic 

摘      要：Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease with a prevalence up to 8% in males over 60 years of age.1 This is a complex disorder characterized by permanent and focal dilation of abdominal aorta that exceeds at least 50% of the normal diameter. In these patients, the aortic diameter progressively expands boosted by smoking and aging as major risk factors. Unfortunately, aneurysm growth increases the risk of aortic rupture, a life-threatening emergency that carries a mortality rate of 80%. Despite the increasing effort of the scientific community to identify therapeutic strategies for AAA, there are currently no pharmacological tools that ameliorate aneurysm expansion, while the underlying mechanisms involved in this disease are not completely understood.