ADAM17/TACE:a key molecule in brain injury regeneration

作     者：Samuel Dominguez-Garcia Carmen Castro Noelia Geribaldi-Doldan 

作者机构：Area de Fisiologia Facultad de Medicina Universidad de Cadiz Cadiz Spain Instituto de Investigacion e Innovacion Biomedica de Cadiz (INIBICA) Universidad de Cadiz Cadiz Spain 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第8期

页      面：1378-1379页

核心收录：

学科分类：10[医学] 

基　　金：supported by the Spanish Consejería de Innovación,Ciencia y Empleo,Junta de Andalucía(P10CTS6639) Ministerio de Econmía y Competitividad(BFU 2015-6852-R,MINECO/FEDER)(both to CC) 

主　　题：ADAM17/TACE key molecule injury regeneration 

摘      要：It has been many years since the tumor necrosis factor-a-converting enzyme,also known as ADAM17/TACE, was described as the enzyme that does it all because of its role in neurodegenerative diseases and in several physiological processes including proteolysis, adhesion, intracellular signaling, migration and proliferation. ADAM17/TACE is an integral membrane protein that belongs to the disintegrin and metalloprotease (ADAM) family. Several years ago, Romero-Grimaldi et al.