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Science China Chemistry 1983年第3期26卷 262-273页

作者：周绍慈卢湘岳殷慧镇 East China Normal University Department of biology Shanghai Research Laboratory of Brain Function

Experiments performed on 103 rabbits immobilized with Flaxedil, and the recording of the electrical discharges of single MGB neuron caused by clicks, burst or sustained tone showed marked inhibition of the reaction of 47 out of 75 (62.7%) MGB units responding to sound stimuli, when the amygdaloid complex was stimulated. The latent period of such an inhibitory effect was 5-12 msec and its duration about 2-13 msec. Evoked responses with the latency of 1-2 msec for the stimulation of medial, central and lateral nuclei of amygdala could be recorded from the temporal and parietal cortex. The largest response was recorded from Woolsey’s AI area of the temporal cortex. Stimulation of the Woolsey’s AI auditory area could also result in a distinct inhibition of the spontaneous as well as the evoked discharges of MGB neurons in response to sound stimulation. Moreover, application of 1% procaine to the surfac. of auditory cortex could block the inhibitory effect of the amygdala on the MGB neurons. Based on the fac

关键词： MGB STUDY OF INHIBITORY EFFECT OF AMYGDALOID STIMULATION ON AUDITORY RESPONSE OF MEDIAL GENICULATE BODY AND ANALYSIS OF TRANSMISSIVE PATHWAY OF THE SAID EFFECT

Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer

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Genes & Diseases 2023年第4期10卷 1180-1182页

作者： J.Bargiela-Iparraguirre J.M.Herrero N.Pajuelo-Lozano M.Perez R.Perona A.G.Quiroga C.Calés I.Sanchez-Perez Dpto.de Bioquímica.fac.Medicina UAMMadrid 28029Spain Biomedical Research Institute of Madrid CSIC/UAMMadrid 28029Spain Cancer Stem Cell and Fibroinflammatory Microenvironment Group Chronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid 28034Spain Unidad Asociada de Biomedicina UCLM-CSIC Madrid 28029 Spain CIBER for Rare Diseases(CIBERER) Instituto de Salud CarlosⅢ Madrid 28029Spain Dpto.de Anatomía Histología y Neurociencia.Fac.Medicina UAMMadrid 28029Spain g Dpto.de Química Inorgánica Fac.Ciencias UAMMadrid 28049Spain

Gastric cancer(GC)is worldwide the sixth most diagnosed and third leading cause of cancer deaths,with poor and late prognosis,probably due to post-surgery adjuvant treatment resistance and lack of a thorough panel of prognostic *** have previously shown that mitotic arrest deficient 2(MAD2,encoded by MAD2L1),a key protein of the spindle assembly checkpoint,is relevant in GC cells;its interference impairs migration and growth,while its overexpression cor-relates with tumorigenesis.

关键词： MAD2 tumorigenesis Gastric

Proapoptotic effects of selected indole phytoalexins in cancer cells.

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Proapoptotic effects of selected indole phytoalexins in canc...

睫状体平部玻璃体切除术联合内界膜剥离术治疗慢性黄斑水肿

第十五届国际药理学大会

作者： Mojzis Jan Rlatova Martina Sarissky Marek Kutschy Peter Mojzisova Gabriela Mirossay Ladislav P.J.Safarik Univ. Fac.Med.Dept.Pharmacol.KosiceSlovak Republic. P.J.Safarik Univ. Fac.Med.Dept.Pharmacol.KosiceSlovak Republic. P.J.Safarik Univ. Fac.Med.Dept.Pharmacol.KosiceSlovak Republic. P. J. Safarik Univ. Fac. Sri ***. Chem. Kosice Slovak Republic. P. J. Safarik Univ. Fac. Med.Dent. Exp. Med Kosice Slovak Republic. P.J.Safarik Univ. Fac. Med.. DeptPharmacol.KosiceSlovak Republic.

＜正＞ Objective: In the present work,we tested selected cruciferous indole phytoalexins for their antiproliferative and proapototic effects on cancer cell lines. Methods: MIT cytotoxicity assay,cell cycle analysis, apoptosis detection by flow cytometry or DNA ***: Our data indicate the highest activity of 1 - methoxybrasinine （MB）. The IC50 was 10 and 5 mmol/L in Jurkat and HL-60 leukemic cells, respectively . However, significant antiproliferative effect of all phytoalexines was also determined at concentration 0.5 mmol/L in both cell lines. In MB - treated cells we found significant increase in the fraction of cells with a sub - G0/G1 DNA content, which is considered to be a marker of cell death by apoptosis. Apoptosis was also confirmed by the annexin V staining and DNA fragmentation. Conclusions: MB exerted potent antiproliferative activity probably due to cell cycle arrest and apoptosis induction. Further studies are necessary to elucidate its mechanism of action, nevertheless, this compound might have a potential to enter pre-clinical trials as a new anticancer drug.

关键词： phytoalexms - cancer-apoptosis

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 33-34页

作者： Avci R. Kaderli B. Avci B. 齐翔云 Department of Ophthalmology Uludag University Fac. of Medicine 16059 Gorukle Bursa Turkey

Background: To evaluate the results of pars plana vitrectomy with peeling of the internal limiting membrane (ILM) in eyes with chronic macular oedema. Methods: PPV with indocyanine green (ICG) assisted peel ing of the ILM was performed in 33 eyes with diabetic (21 eyes) or non- diabetic (12 eyes) macular oedema. Postoperatively, resolution of macular oedema, improvement of visual acuity (VA) and complications were documented. The peeled membranes were submitted for light and transmission electron microscopic evaluation. Results: The mean follow- up time was 12.2 month s. The macular oedema decreased or was resolved in 17 (81% ) eyes in the diabetic group and in 11 (92% ) eyes in the non- diabetic group. VA improved by at least 2 lines in 11 (52% ) eyes in the diabetic group and in 7 (58% ) eyes in the non- diabetic group. The difference between visual acuity improvements of the two groups was not statistically significant (P > 0.05). However, in the diabetic group the difference of visual improvement between cystoid and diffuse type of macular oedema eyes was statistically significant (14% versus 71% , P=0.02). Light and transmission electron microscopy showed the presence of ILM in all specimens. During the follow- up period no recurrence of macular oedema or epiretinal membrane formation was observed. Conclusion: Pars plana vitrectomy with peeling of the ILM and epiretinal membrane leads to the resolution of macular oedema in the majority of eyes. This however, is not always associated with VA improvement. In diabetic eyes, cystoid type of macular oedema appears to be a poor prognostic fac.or for improved VA.

关键词：内界膜剥离术玻璃体切除术黄斑水肿吲哚青绿染色糖尿病组视网膜前膜弥散型非糖尿病性黄斑囊样水肿透射电子显微镜

Optical Dispersion Parameters with Different Orientations for SrLaAlO_4 Single Crystals

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Journal of Materials Science & Technology 2003年第1期19卷 77-80页

作者： Z.El-Gohary, M.El-Nahass, H.Soliman and Y.L.El-Kady Physics Department, fac.lty of Science, Menoufia University, Shebin El- Koom, Egypt Physics Department, fac.lty of Education, Ain Shamd University, Cairo, Egypt Menoufia Univ Fac Sci Dept Phys Shibin Al Kawm Egypt Ain Shams Univ Fac Educ Dept Phys Cairo Egypt

The different optical dispersion parameters of SrLaAIO4 single crystals have been studied by the transmission andreflection measurements at normal incidence for the three orientations 001, 100 and 101 in the spectral range400 nm^2500 *** optical absorption data revealed the existance of allowed indirect and direct transition. Therefractive index has abnormal behaviour in the spectral region 400~900 nm, but has a normal one in the higherwavelength region. The optical dispersion parameters, the single oscillator energy Eo and the dispersion energy Edwere determined and indicated the ionic structure of the material. The high-frequency dielectric constant, the latticedielectric constant and the electronic polarizability were determined by the free carriers and the lattice vibrationmodes. The real dielectric constant (?)1, the dielectric loss tangent (tanδ), the volume (VELF) and the surfac. energyloss function (SELF) have also been discussed.

关键词： Optical parameters Dispersion theory Dielectric constant

防止大的吸附型海洋生物过程的一个评估模式:南美一座水力发电站的Limnoperna fortunei幼虫研究

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AMBIO－人类环境杂志 2007年第B11期36卷 543-547页

作者： Gustavo Darrigran Cristina Damborenea Nancy Greco 王胜 División ZoologiaInvertebradosFac.CienciasNaturalesyMuseoUniversicladNacionaldeLaPlata(UNLP)入侵软体动物研究组 División ZoologiaInvertebradosFac.CienciasNaturalesyMuseoUNLP入侵软体动物研究组 fac. Ciencias Naturales y Museo(FCNyM-UNLP)

全球变化和贸易全球化时生物圈的影响刺激了生物入侵的加剧及它们对生态系统的后续影响。由于大陆性入侵双壳类动物对人造建筑的影响很大,所以非常重要。Limnoperna fortunei于1991年首见于新热带区域。从那时起,它就以240km/a的速度在... 详细信息

全球变化和贸易全球化时生物圈的影响刺激了生物入侵的加剧及它们对生态系统的后续影响。由于大陆性入侵双壳类动物对人造建筑的影响很大,所以非常重要。Limnoperna fortunei于1991年首见于新热带区域。从那时起,它就以240km/a的速度在拉普拉塔河和瓜伊巴(Guaiba)河流域内溯流散布。该种产生大型吸附的方式与Dreissena polymorpha相似。本文描述了南美一座水力发电站的***幼虫生物学。我们提出认识该入侵种生物学是很重要的,并且有必要考虑该站每个部位的幼虫定居模式和密度,以便对大型吸附进行可持续的防止/控制。在***最终会入侵北美和欧洲的假设条件下,本研究具有全球性意义。

关键词：水力发电站吸附型生物过程幼虫南美评估海洋生物入侵

Identification of cyclic phosphatidic acid （cyclic-PA） in mammalian tissues and its receptor subtype-selective effects on the LPA receptors.

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Identification of cyclic phosphatidic acid （cyclic-PA） in ...

Clustering of halophytic species from Cyprus based on ionic contents

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作者： Kimiko Murakami-Murofushi Tetsuyuki Kobayashi Susumu Kobayashi Hiromu Murofushi David J. Fischer Karoly Liliom Gabor Tigyi Dept. Biol. Fac. SciOchanomizu Univ.Tokyo 112Japan Dept. Biol. Fac. SciOchanomizu Univ.Tokyo 112Japan Dept.Pharmaceut. Sci. Sci. Univ. TokyoTokyo 162Japan Dept.Biochem.Biophys. Fac. Sci.Univ. TokyoTokyo 113Japan Dept. Physiol.Biophys. The Univ. TennesseeTN 38163USA Dept. Physiol.Biophys. The Univ. TennesseeTN 38163USA Dept. Physiol.Biophys. The Univ. TennesseeTN 38163USA

＜正＞Cyclic-PA was first isolated from myxoamoebae of a true slime mold, Physarum polycephalum, and designated as PHYLPA or cLPA. The biological effects of cyclic-PA include （i） the antimitogenic regulation of the cell cycle, （ii） regulation of Ca2+ release, （iii） regulation of actin rearrangement, （iv） inhibition of tumor cell invasiveness, and （v） the inhibition of apoptosis.

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Phyton-International Journal of Experimental Botany 2019年第1期88卷 63-68页

作者： Ozturk M S Gucel V Altay MSA Ahmad MY Ashraf M Ashraf Botany Department&Centre for Environmental studies Ege University35040IzmirTurkey Environmental Sciences Institute Near East University99138Turkish Republic of Northern Cyprus biology Department Fac.of Sciences and ArtsHatay Mustafa Kemal University31060HatayTurkey Department of Botany University of Agriculture38000FaisalabadPakistan Deputy Chief Scientist Nuclear Inst.for Agriculture and biology(NIAB) 38000FaisalabadPakistan Pakistan Science Foundation 1-Constitution AvenueG-5/244050IslamabadPakistan

This paper presents the work conducted on the chemical constituents of some common and widely distributed halophyte taxa from Cyprus with the aim that these studies will help in the evaluation of halophytes for different economical *** plant species of Crithmum maritimum L.,Limbarda crithmoides(L.)Dumort,Atriplex portulacoides L.,Salsola kali L.,Atriplex halimus L.,Limonium oleifolium Mill.,***(Boiss.)Kuntze;and Tetraena alba(L.f.)Beier&Thulin were collected in the middle of *** shoot tissue and leaf samples were collected from the natural habitats and left for drying under air circulation followed by placing them in oven at 60°C for 96 *** material was crushed using mortar and pestle and subjected to an analysis of macro-and micro-nutrients and biochemical compounds.K+/Na+in the leaf tissues of the dicot species showed relatively high values depicting their behavior as Na+includes but very low Cl-levels were *** of the species investigated here in 4 TFAA content was rather *** ranging from 0.5%to 1%dry weight were exhibited in one ***,only 3 species showed very low TFAA *** may be due to low nitrogen availability in their *** phenetic analyses of eight halophyte species performed on the data matrix using Ntsys-pc program version 2.1 revealed that,cluster analysis of the overall results obtained here leads to 2 *** discrimination appears to be as a result of their different abilities to accumulate either proline or glycine betaine.

关键词： Anions Cations Fodder Minerals Organic osmolytes Salt tolerant

Discovery of the Proterozoic low-grade metamorphicsubmarine carbonatite lavas in China

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Chinese Science Bulletin 1998年第5期43卷 416-420页

作者： Yongbei Zhang Qirong Wei Chengyan Xiu Hao Wang China Univ Geosci Fac Earth Sci Wuhan 430074 Peoples R China

The carbonatite lavas found in the Kunyang Group were formed in submarine extrusive environment. Many igneous features (e.g. colors, textures, structures, minerals, inclusions) are clear. But most of their petrologic characteristics are different from typical carbonatites over the world. Most petrologic details of the rocks are given by comparison with other carbonatites and adjacent sedimentary dolomites. The discovery of the lavas proves that the carbonatite volcano also existed in Kunyang rift.

关键词： carbonatite lavas submarine extrusion Proterozoic low-grade metamorphic rock Kunyang rift.

Bursting the unfolded protein response accelerates axonal regeneration

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Neural Regeneration Research 2016年第6期11卷 892-893页

作者： Maritza Onate Geroscience Center for Brain Health and Metabolism Santiago Chile Center for Integrative biology Universidad Mayor Santiago Chile Biomedical Neuroscience Institute Faculty of Medicine University of Chile Santiago Chile Program of Cellular and Molecular biology Institute of Biomedical Sciences Center for Molecular Studies of the Cell University of ChileSantiago Chile Millenium Nucleus for Regenerative biology Santiago Chile Buck Institute for Research on Aging Novato CA 94945 USA Department of Immunology and Infectious Diseases Harvard School of Public Health Boston MA USA

Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system(PNS)is *** pathological state are are associated with weakness,pain,and loss of motor and sensory *** than 100 types of peripheral neuropathies have been identified,with distinct symptoms and prognosis classified according to the type of damage to the *** to peripheral nerves results in disabling loss of sensory and motor func-

关键词：未折叠蛋白反应轴突再生神经系统周围神经损伤类型运动功能病理状态 PNS