Identification of cyclic phosphatidic acid (cyclic-PA) in mammalian tissues and its receptor subtype-selective effects on the LPA receptors.
作者单位：Dept. Biol.Fac. SciOchanomizu Univ.Tokyo 112Japan Dept.Pharmaceut. Sci.Sci. Univ. TokyoTokyo 162Japan Dept.Biochem.Biophys.Fac. Sci.Univ. TokyoTokyo 113Japan Dept. Physiol.Biophys.The Univ. TennesseeTN 38163USA
会议名称：《Third Congress of the Asian-Pacific Organization for Cell Biology》
会议日期：1998年
学科分类：0710[理学-生物学] 07[理学] 071002[理学-动物学]
摘 要：Cyclic-PA was first isolated from myxoamoebae of a true slime mold, Physarum polycephalum, and designated as PHYLPA or cLPA. The biological effects of cyclic-PA include (i) the antimitogenic regulation of the cell cycle, (ii) regulation of Ca2+ release, (iii) regulation of actin rearrangement, (iv) inhibition of tumor cell invasiveness, and (v) the inhibition of apoptosis.