Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer

作     者：J.Bargiela-Iparraguirre J.M.Herrero N.Pajuelo-Lozano M.Perez R.Perona A.G.Quiroga C.Calés I.Sanchez-Perez J.Bargiela-Iparraguirre;J.M.Herrero;N.Pajuelo-Lozano;M.Perez;R.Perona;A.G.Quiroga;C.Calés;I.Sanchez-Perez

作者机构：Dpto.de Bioquímica.Fac.MedicinaUAMMadrid 28029Spain Biomedical Research Institute of MadridCSIC/UAMMadrid 28029Spain Cancer Stem Cell and Fibroinflammatory Microenvironment GroupChronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid 28034Spain Unidad Asociada de Biomedicina UCLM-CSIC Madrid 28029Spain CIBER for Rare Diseases(CIBERER) Instituto de Salud CarlosⅢMadrid 28029Spain Dpto.de AnatomíaHistología y Neurociencia.Fac.Medicina UAMMadrid 28029Spain g Dpto.de Química Inorgánica Fac.Ciencias UAMMadrid 28049Spain 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第4期

页      面：1180-1182页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：MICINN grant number PID2019-106220RB100.Instituto de Salud CarlosⅢ,Spain,grant PI200335,(all co-financed through Fondo Europeo de Desarrollo Regional(FEDER)"Una manera de hacer Europa") supported by a grant FPU15/04669,funded by Ministerio de Educacion,Cultura y Deporte,Spain.JMH FPI-UAM 2021 from Universidad Auton-oma de Madrid(Molecular BioSciences PhD programme) 

主　　题：MAD2 tumorigenesis Gastric 

摘      要：Gastric cancer(GC)is worldwide the sixth most diagnosed and third leading cause of cancer deaths,with poor and late prognosis,probably due to post-surgery adjuvant treatment resistance and lack of a thorough panel of prognostic *** have previously shown that mitotic arrest deficient 2(MAD2,encoded by MAD2L1),a key protein of the spindle assembly checkpoint,is relevant in GC cells;its interference impairs migration and growth,while its overexpression cor-relates with tumorigenesis.