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The silent threat and countermeasures:Navigating the mixture risk of endocrine-disrupting chemicals on pregnancy loss in China

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Eco-Environment & Health 2024年第3期3卷 266-270页

作者： Yaqian Xu Thanh Wang Jia Yin Ligang Hu Chunyang Liao School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Physics Chemistry and Biology(IFM)Link€oping University58183 Link€opingSweden Department of Thematic Studies environmental Change(TemaM) Link€oping University58183 Link€opingSweden College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Currently,many countries and regions worldwide face the challenge of declining population growth due to persistently low rates of female *** 2017,China's birth rate has hit historic lows and continued to decline,with the death rate now equaling the birth *** have emerged regarding the potential impact of environmental contaminants on reproductive health,including pregnancy ***-disrupting chemicals(EDCs)like phthalate esters(PAEs),bisphenol A(BPA),triclosan(TCS),and perfluoroalkyl substances(PFASs)have raised attention due to their adverse effects on biological *** China's 14th Five-Year Plan(2021–2025)for national economic and social development included the treatment of emerging pollutants,including EDCs,there are currently no national appraisal standards or regulatory frameworks for EDCs and their *** the risk of EDC mixtures is an urgent matter that needs consideration from China's perspective in the near *** this Perspective,we delve into the link between EDC mixture exposure and pregnancy loss in *** focus areas include establishing a comprehensive national plan targeting reproductive-aged women across diverse urban and rural areas,understanding common EDC combinations in women and their surrounding environment,exploring the relationship between EDCs and pregnancy loss via epidemiology,and reconsidering the safety of EDCs,particularly in mixtures and low-dose *** envision that this study could aid in creating preventive strategies and interventions to alleviate potential risks induced by EDC exposure during pregnancy in China.

关键词： Endocrine-disrupting chemicals Targeted and nontargeted analysis Mixture effect Birth rate Pregnancy loss

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Convenient Self-Heating Instant Food Causes Significant Increasing Human Exposure to Organophosphate Esters

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Environment & Health 2024年第1期2卷 52-61页

作者： Xiaomin Li Yuhan Yin Wei Zhou Hongting Li Boyuan Hu Yajing Cui Ruoxian Zhou Peilong Wang Jianjie Fu Institute of Quality Standard and Testing Technology for Agro-Products The Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

The self-heating lunch box(SHLB)is a kind of popular instant food in China,yet little is known about the associated chemical release risk during its heating *** this study,we investigated organophosphate esters(OPEs)in original unheated food(UF),SHLB-heated processed food(HF)and potential OPE release from SHLB packaging *** higher concentrations of OPEs were observed in HF(267±246 ng/g dry weight(dw))than in UF(163±211 ng/g dw)(p<0.001),suggesting an introduction of additional OPEs during heating ***(2-chloroethyl)phosphate,triethyl phosphate,and tris(2-chloroisopropyl)phosphate exhibited the highest absolute increased amounts,with 137,48.8,and 149%growth in HF than in UF,*** testing revealed that packaging materials were rich in OPEs and can release considerable OPEs into food simulates(range,14.7-90.8 ng/g;mean,47.9±21.8).Influencing factors(temperature,contact time,oily food)on OPE migration from packaging materials to food were *** temperature and longer contact time increased OPE contents in food ***,the presence of abundant OPEs in UF and significant correlations among different OPEs(p<0.05)suggested contamination happened during food processing and *** one SHLB meal a day,a 12-fold increase of OPE intake was observed for humans compared to those following a traditional dietary *** the high-exposure(95th percentile)scenario,hazard quotients of nine OPEs ranged from 0.00005 to *** results suggested that the SHLB exposure pathway of OPEs should be particularly paid attention to in specific subpopulations that prefer this dietary habit.

关键词： Organophosphate esters Self-heating lunch box Migration influencing factors Human exposure

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A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts

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Science China(Life Sciences) 2024年第6期67卷 1242-1254页

作者： Xianliang Huang Qing Li Yanan Xu Ang Li Shanzheng Wang Yusheng Chen Chunrui Zhang Xia Zhang Hailin Wang Cong Lv Baofa Sun Shaoqin Li Le Kang Bing Chen School of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230601China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain ***,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta *** results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or *** individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary ***,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of *** summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria

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environmental Toxicology:The Importance of Disease-Specific In Vitro Models

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Environment & Health 2024年第2期2卷 65-67页

作者： Francesco Faiola Nuoya Yin Renjun Yang State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

environmental toxicology focuses on the effects of environmental chemicals on human *** ensure a comprehensive assessment of exposure risks,it is crucial to consider populations that are already affected by preexisting medical conditions,as they may exhibit increased sensitivity to environmental *** disease-specific animal models have been developed to simulate a range of diseases such as cancer,diabetes,and neurodevelopmental ***,a significant limitation of these models is the presence of species variations.

关键词： diseases chemicals exposure

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Recent Advances in Nanoengineering of Electrode-Electrolyte Interfaces to Realize High-Performance Li-Ion Batteries

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Energy & environmental Materials 2024年第3期7卷 1-13页

作者： Na-Yeong Kim Ilgyu Kim Behnoosh Bornamehr Volker Presser Hiroyuki Ueda Ho-Jin Lee Jun Young Cheong Ji-Won Jung School of Materials Science and Engineering University of UlsanTechno saneop-ro 55 beon-gilNam-guUlsan 44776Korea INM-Leibniz Institute for New Materials Campus D2266123Saarbrücken Germany Department of Materials Science and Engineering Campus D2266123Saarbrücken Germany saarene-Saarland Center for Energy Materials and Sustainability Campus C4266123Saarbrücken Germany Institute for Frontier Materials(IFM) Deakin University221 Burwood HighwayBurwood Victoria 3125Australia Battery Research and Innovation Hub Deakin University5/154 Highbury RoadBurwood Victoria 3125Australia Bavarian Center for Battery Technology(BayBatt)and Department of chemistry University of BayreuthUniversitatsstraBe 3095447Bayreuth Germany

A suitable interface between the electrode and electrolyte is crucial in achieving highly stable electrochemical performance for Li-ion batteries,as facile ionic transport is *** research and development have recently been conducted to form a stable interface between the electrode and ***,it is essential to investigate emerging knowledge and contextualize *** nanoengineering of the electrode-electrolyte interface has been actively researched at the electrode/electrolyte and interphase *** review presents and summarizes some recent advances aimed at nanoengineering approaches to build a more stable electrode-electrolyte interface and assess the impact of each approach ***,future perspectives on the feasibility and practicality of each approach will also be reviewed in ***,this review aids in projecting a more sustainable research pathway for a nanoengineered interphase design between electrode and electrolyte,which is pivotal for high-performance,thermally stable Li-ion batteries.

关键词： battery electrode electrolyte interface lithium nanoengineering

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Carbendazim residue in plant-based foods in China:Consecutive surveys from 2011 to 2020

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environmental Science and Ecotechnology 2024年第1期17卷 109-118页

作者： Dou Wang Guiling Yang Xiao Yun Ting Luo Hao Guo Liying Pan Wei Du Yanhua Wang Qiang Wang Pu Wang Qinghua Zhang Yun Li Nan Lin State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Laboratory(Hangzhou)for Risk Assessment of Agricultural Products of Ministry of AgricultureInstitute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou310021ZhejiangChina College of Urban and environmental Sciences Peking UniversityBeijing100871China Yunnan Provincial Key Laboratory of Soil Carbon Sequestration and Pollution Control Faculty of Environmental Science&EngineeringKunming University of Science&TechnologyKunming650500China Hubei Key Laboratory of Industrial Fume and Dust Pollution Control School of Environment and HealthJianghan UniversityWuhan430056China State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Key Laboratory of Agro-Product Quality and Safety of Ministry of Agriculture Institute of Quality Standards and Testing Technology for Agro-ProductsChinese Academy of Agricultural SciencesBeijing100081China Department of environmental Health School of Public HealthShanghai Jiao Tong UniversityShanghai200025China

Carbendazim,a widely used fungicide in China,has been found to have reproductive toxicity and mutagenic ***,information on the spatial-temporal variations of carbendazim residues in food in China is ***,we investigated the presence of carbendazim in China's plant-based foods from 2011 to 2020,evaluated the spatial-temporal characteristics,and assessed the associated exposure risks in the Chinese *** results revealed a high detection frequency of carbendazim in fruits(26.4%)and high concentrations in vegetables(~110 mg kg^(-1)),indicating widespread misuse of the *** acute risks of consuming certain vegetables and cereals exceeded the recommended limits by up to 12 and 5 times,*** there has been a decline in carbendazim residue levels in food since the implementation of the Chinese government's action plan for zero growth of pesticide use in 2015,some provinces still exhibited high levels of carbendazim in multiple food categories,which were positively correlated with annual pesticide *** highlight that carbendazim contamination reflects the broader issue of pesticide use in *** emphasizes the need for committed and targeted national policies to reduce carbendazim residues in food and suggests that such measures could also regulate the use of other pesticides,given that pesticide abuse in China is not limited to specific *** call for the re-evaluation of maximum residue limits of carbendazim,particularly in highly consumed foods such as cereals.

关键词： Carbendazim Plant-based foods China Spatial-temporal variations Exposure and risk assessment

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Enhanced Research Needed on the Structural Analogues of Chlorinated Paraffins as Emerging Contaminants of Concern

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Environment & Health 2024年第10期2卷 681-683页

作者： Weifang Chen Dazhou Ren Qian Liu Qunfang Zhou Jiyan Liu Guibin Jiang School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China the Research Center for Eco-environmental Sciences Chinese Academy of Sciences(RCEESCAS).

INTRODUCTION Structural analogues of chlorinated paraffins(CPs)are compounds that contain the chlorinated n-alkanes skeleton of CPs and other functional ***,some structural analogues of CPs at high levels were detected in the environment and general population.1−5 The atmospheric concentrations of unsaturated short,medium,and long chain chlorinated olefins(COs)were 0.01−0.27,0.02−0.56,and 0.01−0.55 ng/m3 in China.1 Over 700 brominated-chlorinated paraffin and brominated-chlorinated olefin congeners(BCPs and BCOs)were found in different matrices in *** concentrations of BCPs and BCOs in dust samples(median concentrations of 5.4 and 0.18μg/g,respectively)are comparable to CPs,and 1−2 orders of magnitude higher than those in the atmosphere and sediments at some sites.

关键词： analogues chlorinated alkanes

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Percutaneous Penetration and Dermal Exposure Risk Assessment of UV Absorbents in Sunscreens and Isolation Cosmetics

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Environment & Health 2024年第8期2卷 541-552页

作者： Lu Bai Juan Li Binbin Guo Ruitong Cai Chunyan Zhao Yanli Guo Yawei Wang Guibin Jiang State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310000China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Pharmacy Lanzhou UniversityLanzhou 730000China China Innovation Center Shimadzu(China)Co.Beijing 100020China

Ultraviolet absorbents(UVs)make up a group of industrial chemicals that is used in various consumer products and industrial *** to their extensive production and usage,UVs have been detected in multiple environmental ***,UVs have garnered significant attention because of their probable adverse impacts on human health and the *** study examines UVs levels in sunscreens and isolation cosmetics and further assesses human exposure to UVs through the application of *** total concentrations of nine UVs in 87 sunscreen and isolation cosmetic products ranged from 75.5 to 4.25×10^(4) ng/*** them,2-(2-hydroxy-5-methyl-phenyl)benzotriazole(UV-P)and 2-hydroxy-4-(octoxy)benzophenone(UV-531)had the highest *** of the EpiSkin model indicated rapid absorption and strong dermal penetration by UV-328 following 36 h of exposure with a cumulative absorption rate of 41.8%±2.82%.Other congeners are expected to be distributed in the dermal tissue and donor ***,this study explored potential mechanisms implicating skin biochemical barriers in the metabolism and transport of *** potential of UVs to act as substrates and inhibitors of P450 enzymes was assessed,and their metabolites were *** docking simulations demonstrated that UVs can significantly interact and bind with three transport proteins in skin:MDR1,OATP2B1,and *** UVs exposure through the skin was assessed,revealing that dermal absorption levels of UV-P in sunscreen sprays(4.66×10^(3) ng/(kg bw day))and sunscreens(6.01×10^(3) ng/(kg bw day))were close to or exceeded the reference dose(RfD)and therefore require more attention.

关键词： ultraviolet absorbents sunscreen dermal exposure dermal penetration risk assessment

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An overview for monitoring and prediction of pathogenic microorganisms in the atmosphere

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Fundamental Research 2024年第3期4卷 430-441页

作者： Jianping Huang Danfeng Wang Yongguan Zhu Zifeng Yang Maosheng Yao Xiaoming Shi Taicheng An Qiang Zhang Cunrui Huang Xinhui Bi Jiang Li Zifa Wang Yongqin Liu Guibing Zhu Siyu Chen Jian Hang Xinghua Qiu Weiwei Deng Huaiyu Tian Tengfei Zhang Tianmu Chen Sijin Liu Xinbo Lian Bin Chen Beidou Zhang Yingjie Zhao Rui Wang Han Li Collaborative Innovation Center for Western Ecological Safety College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China Research Center for Eco-environmental Sciences Chinese Academy of SciencesBeijing 100085China National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease(Guangzhou Medical University)Guangzhou 510230China College of environmental Sciences and Engineering Peking UniversityBeijing 100871China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Vanke School of Public Health Tsinghua UniversityBeijing 100084China State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Pan-third Pole Environment Lanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 510640

Corona virus disease 2019(COVID-19)has exerted a profound adverse impact on human *** have demonstrated that aerosol transmission is one of the major transmission routes of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Pathogenic microorganisms such as SARS-CoV-2 can survive in the air and cause widespread infection among *** monitoring of pathogenic microorganism transmission in the atmosphere and accurate epidemic prediction are the frontier guarantee for preventing large-scale epidemic *** of pathogenic microorganisms in the air,especially in densely populated areas,may raise the possibility to detect viruses before people are widely infected and contain the epidemic at an earlier *** multi-scale coupled accurate epidemic prediction system can provide support for governments to analyze the epidemic situation,allocate health resources,and formulate epidemic response *** review first elaborates on the effects of the atmospheric environment on pathogenic microorganism transmission,which lays a theoretical foundation for the monitoring and prediction of epidemic ***,the monitoring technique development and the necessity of monitoring pathogenic microorganisms in the atmosphere are summarized and ***,this review introduces the major epidemic prediction methods and highlights the significance to realize a multi-scale coupled epidemic prediction system by strengthening the multidisciplinary cooperation of epidemiology,atmospheric sciences,environmental sciences,sociology,demography,*** summarizing the achievements and challenges in monitoring and prediction of pathogenic microorganism transmission in the atmosphere,this review proposes suggestions for epidemic response,namely,the establishment of an integrated monitoring and prediction platform for pathogenic microorganism transmission in the atmosphere.

关键词： Aerosol transmission Epidemic monitoring methods Epidemic prediction modelsEpidemic response Multidisciplinary cooperation

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ZNT1 Involves Cuproptosis through Regulating MTF1-conduced Expression of MT1X under Copper Overload

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生态毒理学报 2024年第4期19卷 53-70页

作者： Wu Yue Yang Tingyun Yan Bo Ai Youwei Chen Fang Ma Juan Liu Sijin State Key Laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese A cademy of SciencesBeijing 100085China university of Chinese Academy of Sciences Beijing 100049China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Industrial activities such as smelting emissions,mineral combustion and industrial wastewater discharge might lead to copper pollution in the *** kind of copper pollution has harmful effects on aquatic o rganisms,plants and animals through direct or indirect ***,the current understanding of the toxicity of copper is rather *** overload can perturb intracellular homeostasis and induce oxidative stress and e ven cell ***,cuproptosis has been identified as a copper-dependent form of cell death induced by o xidative stress in *** uncover here that zinc transporter 1(ZNT1)is an important regulator involved in ***,we established the copper overload-induced cell death model with the overexpression of copper importer SLC31A1 in HeLa *** this model,we conducted unbiased genome-wide CRISPR-Cas9 screens in cells treated with *** results revealed a significant enrichment of ZNT1 gene in both library A and library B *** out of ZNT1 in HeLa cells notably prevented *** knockout of metal transcription factor 1(MTF1)in ZNT1-deficient cells nearly abolished their ability to resist copper-induced cell ***,overexpression of metallothionein 1X(MT1X)in the double-knockout cells could p artially restored the resistance to cuproptosis by loss of ***,knockout of ZNT1 could promote MT1X expression by activating *** a consequence,the interaction between MT1X and copper was e nhanced,reducing the flow of copper into mitochondria and eliminating mitochondria *** together,this study reveals the important role of ZNT1 in cuproptosis and shows MTF1-MT1X axis mediated resistance to c ***,our study will help to understand the regulatory mechanism of cellular and systemic copper homeostasis under copper overload,and present insights into novel treatments for damages caused by both genetic copper overload diseases and enviro

关键词： copper cuproptosis ZNT1 MT1X

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