Convenient Self-Heating Instant Food Causes Significant Increasing Human Exposure to Organophosphate Esters

作     者：Xiaomin Li Yuhan Yin Wei Zhou Hongting Li Boyuan Hu Yajing Cui Ruoxian Zhou Peilong Wang Jianjie Fu 

作者机构：Institute of Quality Standard and Testing Technology for Agro-ProductsThe Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China State Key Laboratory of Environmental Chemistry and EcotoxicologyResearch Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of EnvironmentHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China 

出 版 物：《Environment & Health》 (环境与健康（英文）)

年 卷 期：2024年第2卷第1期

页      面：52-61页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (22276214,22022611,and 21777190) the Youth Innovation Promotion Association CAS (Y2022020) 

主　　题：Organophosphate esters Self-heating lunch box Migration influencing factors Human exposure 

摘      要：The self-heating lunch box(SHLB)is a kind of popular instant food in China,yet little is known about the associated chemical release risk during its heating *** this study,we investigated organophosphate esters(OPEs)in original unheated food(UF),SHLB-heated processed food(HF)and potential OPE release from SHLB packaging *** higher concentrations of OPEs were observed in HF(267±246 ng/g dry weight(dw))than in UF(163±211 ng/g dw)(p0.001),suggesting an introduction of additional OPEs during heating ***(2-chloroethyl)phosphate,triethyl phosphate,and tris(2-chloroisopropyl)phosphate exhibited the highest absolute increased amounts,with 137,48.8,and 149%growth in HF than in UF,*** testing revealed that packaging materials were rich in OPEs and can release considerable OPEs into food simulates(range,14.7-90.8 ng/g;mean,47.9±21.8).Influencing factors(temperature,contact time,oily food)on OPE migration from packaging materials to food were *** temperature and longer contact time increased OPE contents in food ***,the presence of abundant OPEs in UF and significant correlations among different OPEs(p0.05)suggested contamination happened during food processing and *** one SHLB meal a day,a 12-fold increase of OPE intake was observed for humans compared to those following a traditional dietary *** the high-exposure(95th percentile)scenario,hazard quotients of nine OPEs ranged from 0.00005 to *** results suggested that the SHLB exposure pathway of OPEs should be particularly paid attention to in specific subpopulations that prefer this dietary habit.