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Science China(Life Sciences) 2016年第1期59卷 89-92页

作者： Shuangli Mi Arne Klungland Yun-Gui Yang Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and Development CAS Center for Excellence in Molecular Cell Science Beijing Institute of Genomics Chinese Academy of Sciences Department of Microbiology Division of Diagnostics and Intervention Institute of Clinical Medicine Oslo University HospitalRikshospitalet Department of Molecular Medicine Institute of Basic Medical Sciences University of Oslo

Tomas Lindahl contributed his scientific career to unveiling fundamental mechanisms of DNA decay and repair. He made several ground-breaking discoveries on genome in- stability, novel DNA repair activities and pathway... 详细信息

关键词：碱基切除修复诺贝尔奖得主托马斯科学成果归结化学科学生涯修复机制

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Managing uterine artery pseudoaneurysm post-hysteroscopic surgery:Clinical insights and future directions

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World Journal of Clinical Cases 2024年第32期12卷 6547-6550页

作者： Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial discusses the case report by Kakinuma et al,which details a rare occurrence of uterine artery pseudoaneurysm following hysteroscopic *** case highlights diagnostic challenges and management strategies for this uncommon *** editorial explores the implications for clinical practice,emphasizing the importance of early recognition and appropriate intervention to prevent potential severe *** research directions to increase the understanding and management of uterine artery pseudoaneurysm in similar clinical settings.

关键词： Uterine artery pseudoaneurysm Hysteroscopic surgery Vascular complications intervention implications Case report

Reliability and concurrent validity of postural asymmetry measurement in adolescent idiopathic scoliosis

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World Journal of Orthopedics 2017年第1期8卷 68-76页

作者： Ashleigh Prowse Berit Aslaksen Marie Kierkegaard James Furness Paul Gerdhem Allan Abbott Faculty of Health Science and Medicine Bond University Department of Physio-therapy Karolinska University Hospital Department of Neurobiology Care Sciencesand Society (NVS)Division of PhysiotherapyKarolinska Institutet Department of Clinical Science Intervention and Technology (CLINTEC)Karolinska Institutet Department of Medical and Health Sciences Division of PhysiotherapyFaculty of Health SciencesLink?ping University

AIM To investigate the reliability and concurrent validity of the Baseline~? Body Level/Scoliosis meter for adolescent idiopathic scoliosis postural assessment in three anatomical *** This is an observational reliability and concurrent validity study of adolescent referrals to the Orthopaedic department for scoliosis screening at KarolinskaUniversity Hospital, Stockholm, Sweden between MarchMay 2012. A total of 31 adolescents with idiopathic scoliosis(13.6 ± 0.6 years old) of mild-moderate curvatures(25°± 12°) were consecutively recruited. Measurement of cervical, thoracic and lumbar curvatures, pelvic and shoulder tilt, and axial thoracic rotation(ATR) were performed by two trained physiotherapists in one day. The intraclass correlation coefficient(ICC) was used to determine the inter-examiner reliability(ICC2,1) and the intra-rater reliability(ICC3,3) of the Baseline~? Body Level/Scoliosis meter. Spearman's correlation analyses were used to estimate concurrent validity between the Baseline~? Body Level/Scoliosis meter and Gold Standard Cobb angles from radiographs and the Orthopaedic Systems Inc. *** There was excellent reliability between examiners for thoracic kyphosis(ICC2,1 = 0.94), ATR(ICC2,1 = 0.92) and lumbar lordosis(ICC2,1 = 0.79). There was adequate reliability between examiners for cervical lordosis(ICC2,1 = 0.51), however poor reliability for pelvic and shoulder tilt. Both devices were reproducible in the measurement of ATR when repeated by one examiner(ICC3,3 0.98-1.00). The device had a good correlation with the Scoliometer(rho = 0.78). When compared with Cobb angle from radiographs, there was a moderate correlation for ATR(rho = 0.627).CONCLUSION The Baseline~? Body Level/Scoliosis meter provides reliable transverse and sagittal cervical, thoracic and lumbar measurements and valid transverse plan measurements of mild-moderate scoliosis deformity.

关键词： Reliability Validity Scoliosis Posture Assessment

Report on Childhood Obesity in China(8):Effects and Sustainability of Physical Activity intervention on Body Composition of Chinese Youth

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Biomedical and Environmental Sciences 2010年第3期23卷 180-187页

作者： YAN-PING LI XIAO=QI HU EVERT G. SCHOUTEN AI-LING LIU SONG-MING DU LIN-ZHONG LI ZHAO-HuI CUI DONG WANG FRANS J KOK FRANK B HU GUAN-SHENG MA National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China division of Human Nutrition Wageningen University The Netherlands Departments of Nutrition and Epidemiology Harvard School of Public Health USA Department of Global Health and Population Harvard School of Public Health USA

Objectives To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing, China. Methods The study design was one-year cluster randomized controlled trial of physical activity intervention （20 rain of daily exercise in the classroom） with an additional year of follow-up among 4 700 students aged 8-11 years at baseline. Results After the one-year intervention, BMI increased by 0.56 kg/m2 （SD 1.15） in the intervention group and by 0.72 kg/m^2 （SD 1.20） in the control group, with a mean difference of-0.15 kg/m^2 （95% CI： -0.28 to -0.02）. BMI z score decreased by -0.05 （SD 0.44） in the intervention group, but increased by 0.01 （SD 0.46） in the control group, with a mean difference of-0.07 （-0.13 to -0.01）. After another year of follow up, compared to the control group, children in the intervention group had significantly lower BMI （-0.13, -0.25 to -0.01 ）, BMI z score （-0.05, -0.10 to -0.01）, fat mass （-0.27 kg, -0.53 to -0.02） and percent body fat （-0.53, -1.00 to -0.05）. The intervention had a more pronounced effect on weight, height, BMI, BMI z score, and body composition among obese children than among normal weight or overweight children. Compared to the control group, the intervention group had a significantly higher percentage of children who maintained or reduced their BMI z score at year 1 （P-0.008） and year 2 （P=-0.04）. Conclusions These findings suggest that 20 min of daily moderate to vigorous physical activity during the school year is a feasible and effective way to prevent excessive gain of body weight, BMI, and body fatness in primary school students.

关键词： intervention BMI School China

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Non-homologous functions of the AlkB homologs

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分子细胞生物学报:英文版 2015年第6期7卷 494-504页

作者： Rune Ougland Torbjørn Rognes Arne Klungland Elisabeth Larsen Clinic for Diagnostics and intervention and Institute of Medical Microbiology Oslo University HospitalRikshospitalet0027 OsloNorway Department of Anesthesiology Division of Emergencies and Critical CareOslo University HospitalThe Norwegian Radium Hospital0310 OsloNorway Department of Informatics University of Oslo0316 OsloNorway Faculty of Medicine Institute of Basic Medical SciencesUniversity of Oslo0317 OsloNorway

TheDNArepair enzyme AlkB was identified in *** more than three decades *** then,nine mammalian homologs,all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases,have been identified(designated ALKBH1–8 and FTO).While *** AlkB serves as a DNA repair enzyme,only two mammalian homologs have been confirmed to repair DNA in *** other mammalian homologs have remarkably diverse substrate specificities and biological *** recognized by the different AlkB homologs comprise erroneous methyl-and etheno adducts in DNA,unique wobble uridine modifications in certain tRNAs,methylated adenines in mRNA,and methylated lysines on *** phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity,severe sensitivity to inflammation,infertility,growth retardation,and multiple *** we review the present knowledge of the mammalian AlkB homologs and their implications for human disease and development.

关键词： AlkB homologs ALKBH epigenetics histone demethylation DNA repair RNA repair tRNA modiﬁcation

Endogenous DNA Damage and Repair Enzymes—A short summary of the scientific achievements of Tomas Lindahl,Nobel Laureate in Chemistry 2015

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 122-125页

作者： Arne Klungland Yun-Gui Yang Department of Microbiology Division of Diagnostics and InterventionInstitute of Clinical MedicineOslo University Hospital Department of Molecular Medicine Faculty of MedicineInstitute of Basic Medical SciencesUniversity of Oslo CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentBeijing Institute of GenomicsChinese Academy of Sciences

Tomas Lindahl completed his medical studies at Karolinska Institute in ***,his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA *** research is characterized with groundbreaking discoveries on the instability of our genome,the identification of novel DNA repair activities,the characterization of DNA repair pathways,and the association to diseases,throughout his 40 years of scientific career.

关键词： DNA repair completed career instability decay dedicated summary Clare breaking

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CT和MRI引导下经皮冷冻消融术治疗cT1期肾细胞癌：307例病人的中期和长期结果

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国际医学放射学杂志 2020年第6期 736-737页

作者：陈羽琦 S.K.Bhagavatula K.Tuncali P.B.Shyn V.M.Levesque S.L.Chang S.G.Silverman division of Abdominal Imaging and intervention Department of RadiologyBrigham and Women's Hospital Harvard Medical School

摘要经皮消融术治疗c T1期肾细胞癌(RCC)仍未得到充分利用,部分原因是近来评估冷冻消融术长期结果的数据良莠不齐且有限。目的研究在影像引导下经皮冷冻消融术

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METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie Piao Min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui Liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

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World Journal of Gastroenterology 2014年第14期20卷 3986-4000页

作者： Bjarte Fosby Sigrid Nss Johannes R Hov James Traherne Kirsten M Boberg John Trowsdale Aksel Foss Pl-Dag Line Andre Franke Espen Melum Helge Scott Tom H Karlsen Norwegian PSC Research Center Division of CancerSurgery and TransplantationOslo University Hospital Institute of Clinical Medicine Faculty of MedicineUniversity of Oslo KG Jebsen Inflammation Research Centre Research Institute of Internal MedicineOslo University Hospital Department of Transplantation Medicine Division of CancerSurgery and TransplantationOslo University Hospital division of Immunology Department of PathologyUniversity of Cambridge and Cambridge Institute for Medical ResearchUniversity of Cambridge Institute of Clinical Molecular Biology Christian-Albrechts-University Department of Pathology Divisoin of Diagnostics and InterventionInstitute of PathologyOslo University Hospital

AIM: To investigate influence of human leukocyte antigen (HLA) and killer immunoglobuline-like receptor (KIR) genotypes on risks of acute rejection (AR) after liver transplantation (LTX).

关键词： Liver transplantation Primary sclerosing cholangitis Acute rejection Human leukocyte antigen Killer immunoglobulin-like receptor

Willingness of Caregivers to Have Their Children Vaccinated with Pneumococcal Vaccines in the Context of an Innovative Immunization Strategy—Weifang City,Shandong Province,2021

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China CDC weekly 2022年第20期4卷 421-425,I0002-I0004页

作者： Yuan Yang Ting Zhang Yan Wang Libing Ma Shuyun Xie Jian Zhou Weiran Qi Qing Wang Peixi Dai Yuanze Du Luzhao Feng Chunping Wang Weizhong Yang division of Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Weifang Medical University Weifang CityShandong ProvinceChina Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guilin Medical UniversityGuilin CityGuangxi Zhuang Autonomous RegionChina Zhejiang Center for Disease Control and prevention Hangzhou CityZhejiang ProvinceChina Weifang Center for Disease Control and prevention Weifang CityShandong ProvinceChina.

Summary What is already known about this topic?Pneumococcal diseases(PDs)pose a serious health threat to *** is the most costeffective intervention to prevent PDs,but pneumococcal vaccines coverage among children is low in *** is added by this report?This study investigated the willingness of children’s caregivers to have their children vaccinated with pneumococcal vaccines under an innovative policy to offer 1-dose of the 13-valent pneumococcal conjugate vaccines at no charge to *** research found that 70.51%of caregivers were willing to have their infants receive pneumococcal vaccines and that reducing the cost of vaccines may increase caregivers’*** are the implications for public health practice?This is the first evaluation in China of acceptance of pneumococcal vaccines among children under a 1-dose,cost-free *** results provide scientific evidence for updating local and national pneumococcal immunization strategies to promote the use of the pneumococcal vaccine.

关键词： cost policy Strategy