Non-homologous functions of the AlkB homologs

作     者：Rune Ougland Torbjørn Rognes Arne Klungland Elisabeth Larsen 

作者机构：Clinic for Diagnostics and Intervention and Institute of Medical MicrobiologyOslo University HospitalRikshospitalet0027 OsloNorway Department of AnesthesiologyDivision of Emergencies and Critical CareOslo University HospitalThe Norwegian Radium Hospital0310 OsloNorway Department of InformaticsUniversity of Oslo0316 OsloNorway Faculty of MedicineInstitute of Basic Medical SciencesUniversity of Oslo0317 OsloNorway 

出 版 物：《分子细胞生物学报:英文版》 (Journal of Molecular Cell Biology)

年 卷 期：2015年第7卷第6期

页      面：494-504页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the Norwegian Research Council and the South-Eastern Norway Regional Health Authority 

主　　题：AlkB homologs ALKBH epigenetics histone demethylation DNA repair RNA repair tRNA modification 

摘      要：TheDNArepair enzyme AlkB was identified in *** more than three decades *** then,nine mammalian homologs,all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases,have been identified(designated ALKBH1–8 and FTO).While *** AlkB serves as a DNA repair enzyme,only two mammalian homologs have been confirmed to repair DNA in *** other mammalian homologs have remarkably diverse substrate specificities and biological *** recognized by the different AlkB homologs comprise erroneous methyl-and etheno adducts in DNA,unique wobble uridine modifications in certain tRNAs,methylated adenines in mRNA,and methylated lysines on *** phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity,severe sensitivity to inflammation,infertility,growth retardation,and multiple *** we review the present knowledge of the mammalian AlkB homologs and their implications for human disease and development.