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Epigenetics in the modern era of crop improvements

science China life sciences 2025年

作者： Yan Xue Xiaofeng Cao Xiangsong Chen Xian Deng Xingwang Deng Yong Ding Aiwu Dong Chengguo Duan Xiaofeng Fang Lei Gong Zhizhong Gong Xiaofeng Gu Chongsheng He Hang He Shengbo He Xinjian He Yan He Yuehui He Guifang Jia Danhua Jiang Jianjun Jiang Jinsheng Lai Zhaobo Lang Chenlong Li Qing Li Xingwang Li Bao Liu Bing Liu Xiao Luo Yijun Qi Weiqiang Qian Guodong Ren Qingxin Song Xianwei Song Zhixi Tian Jiawei Wang Yuan Wang Liang Wu Zhe Wu Rui Xia Jun Xiao Lin Xu Zhengyi Xu Wenhao Yan Hongchun Yang Jixian Zhai Yijing Zhang Yusheng Zhao Xuehua Zhong Daoxiu Zhou Ming Zhou Yue Zhou Bo Zhu Jiankang Zhu Qikun Liu College of life sciences Institute of Life Science and Green Development Hebei University Biotechnology Research Institute Chinese Academy of Agricultural Sciences College of Biology Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan Engineering and Technology Research Center of Hybrid Rapeseed Hunan University Institute of Advanced Agricultural sciences School of Advanced Agricultural Sciences Peking University state key laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University National Institute of Biological sciences key laboratory of Seed Innovation Institute of Genetics and Developmental Biology Chinese Academy of Sciences School of Advanced Agricultural sciences Peking-Tsinghua Center for Life Sciences Peking University Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University key laboratory of Seed Innovation State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences state key laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in Weifang state key laboratory of Crop Stress Adaptation and Improvement School of Life Sciences Henan University state key laboratory of Maize Bio-breeding National Maize Improvement Center Department of Plant Genetics and Breeding China Agricultural University Frontiers science Center for molecular Design Breeding China Agricultural University Center for Crop Functional Genomics and molecular Breeding China Agricultural University Sanya Institute of China Agricultural University Hainan Yazhou Bay Seed laboratory Institute of Advan

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades,our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits. With recent technological advancements, epigenetic regulations at the single-cell level and at the large-scale population level are emerging as new focuses. This review offers an in-depth synthesis of the diverse epigenetic regulations, detailing the catalytic machinery and regulatory functions. It delves into the intricate interplay among various epigenetic elements and their collective influence on the modulation of crop traits. Furthermore, it examines recent breakthroughs in technologies for epigenetic modifications and their integration into strategies for crop improvement. The review underscores the transformative potential of epigenetic strategies in bolstering crop performance, advocating for the development of efficient tools to fully exploit the agricultural benefits of epigenetic insights.

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Negative PO3-implanted bionic ion transport channels for promoting Li-S battery

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science China Chemistry 2025年

作者： Wenhuan Huang Shun Wang Xuehan Hou Yanan Zhang Xingxing Zhang Yaoxiao Zhao Xilang Jin Huabin Zhang Fei Wang Jian Zhang key laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology School of Materials and Chemical Engineering Xi'an Technological University Chemistry Program Physical Science and Engineering Division King Abdullah University of Science and Technology state key laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Lithium-sulfur （Li-S） battery,as a promising next-generation high-energy-density battery,suffers from lithium polysulfides（LPSs） shuttle and Li dendrites *** crystalline framework-based membranes as separator can effectively absorb and restrain LPSs but without precise structural design principal exploration and mechanism ***,bio-inspired 1D oriented lithium-ion transport channels with molecular negatively charged PO3（-1） have been developed in hybrid tetrazole frameworks for promoting the transmission of Li+*** theoretical calculations and in situ spectroscopy demonstrated the higher binding energy and inhibited diffusion of LPSs in *** assembled PP@PO3Janus separator in Li-S coin cell delivered a high initial capacity of 1410.9 mAh g-1at 0.1 C and a low attenuation rate of 0.038%per cycle over 500 cycles at 5 ***,the high capacities of 862,542 and 409 mAh g-1based on high-sulfur-loading cathodes of 2.6,3.8 and 5.0 mg cm-2at0.5 C were achieved,***,the punch battery of PO3@PP separator with S-cathode of 1.2 mg cm-2has been developed for demonstrating its potentials commercial application,which displays impressive capacity of 873.4 mAh g-1with the retention of～78.9%over 50 cycles.

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TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

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science China life sciences 2025年

作者： Yuan Dong Li Su Sin Man Lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of science and Development Beijing Youan HospitalCapital Medical University laboratory for Clinical Medicine Capital Medical University neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University state key laboratory of molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing key laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

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Deciphering Brain Complexity Using Single-cell Sequencing

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 344-366页

作者： Quanhua Mu Yiyun Chen Jiguang Wang Department of Chemical and Biological Engineering Division of Life Science Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology

The human brain contains billions of highly differentiated and interconnected cells that form intricate neural networks and collectively control the physical activities and high-level cognitive functions,such as memory,decision-making,and social *** data is required to decipher the complexity of cell types,as well as connectivity and functions of the *** newly developed single-cell sequencing technology,which provides a comprehensive landscape of brain cell type diversity by profiling the transcriptome,genome,and/or epigenome of individual cells,has contributed substantially to revealing the complexity and dynamics of the brain and providing new insights into brain development and brain-related *** this review,we first introduce the progresses in both experimental and computational methods of single-cell sequencing *** of single-cell sequencing-based technologies in brain research,including cell type classification,brain development,and brain disease mechanisms,are then elucidated by representative ***,we provided our perspectives into the challenges and future developments in the field of single-cell *** summary,this mini review aims to provide an overview of how big data generated from single-cell sequencing have empowered the advancements in neuroscience and shed light on the complex problems in understanding brain functions and diseases.

关键词： neuroscience Single-cell RNA-seq Cell type Brain development Brain diseases

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Expression and reconstitution of the bioluminescent Ca2+reporter aequorin in human embryonic stem cells,and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes

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science China(life sciences) 2016年第8期59卷 811-824页

作者： Harvey Y.S.Chan Man Chun Cheung Yi Gao Andrew L.Miller Sarah E.Webb division of life science&state key laboratory of molecular neuroscience HKUSTClear Water BayHong KongChina Stem Cell&Regenerative Medicine Consortium Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Marine Biological laboratory Woods Hole MA 02543USA

In order to develop a novel method of visualizing possible Ca2＋ signaling during the early differentiation of hESCs into cardi- omyocytes and avoid some of the inherent problems associated with using fluorescent reporters, we expressed the biolumines- cent Ca2＋ reporter, apo-aequorin, in HES2 cells and then reconstituted active holo-aequorin by incubation withf-coelenterazine. The temporal nature of the Ca2＋ signals generated by the holo-f-aequorin-expressing HES2 cells during the earliest stages of differentiation into cardiomyocytes was then investigated. Our data show that no endogenous Ca2＋ transients （generated by re- lease from intracellular stores） were detected in 1-12-day-old cardiospheres but transients were generated in cardiospheres following stimulation with KC1 or CaC12, indicating that holo-f-aequorin was functional in these cells. Furthermore, following the addition of exogenous ATP, an inositol trisphosphate receptor （IP3R） agonist, small Ca2＋transients were generated from day 1 onward. That ATP was inducing Ca2＋ release from functional IP3Rs was demonstrated by treatment with 2-APB, a known IP3R antagonist. In contrast, following treatment with caffeine, a ryanodine receptor （RyR） agonist, a minima/Ca2＋ response was observed at day 8 of differentiation only. Thus, our data indicate that unlike RyRs, IP3Rs are present and continually functional at these early stages of cardiomyocyte differentiation.

关键词： Ca2+ signaling apo-aequorin expression bioluminescence HES2 human embryonic stem cells hESC-derived cardiospheres IP3 and ryanodine receptors

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Combination of NMR spectroscopy and X-ray crystallography offers unique advantages for elucidation of the structural basis of protein complex assembly

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science China(life sciences) 2011年第2期54卷 101-111页

作者： FENG Wei PAN lifeng ZHANG MingJie division of life science Molecular Neuroscience Center State Key Laboratory of Molecular Neuroscience Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China National laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

NMR spectroscopy and X-ray crystallography are two premium methods for determining the atomic structures of macro-biomolecular *** method has unique strengths and *** the two techniques are highly complementary,they have generally been used separately to address the structure and functions of biomolecular *** this review,we emphasize that the combination of NMR spectroscopy and X-ray crystallography offers unique power for elucidating the structures of complicated protein *** demonstrate,using several recent examples from our own laboratory,that the exquisite sensitivity of NMR spectroscopy in detecting the conformational properties of individual atoms in proteins and their complexes,without any prior knowledge of conformation,is highly valuable for obtaining the high quality crystals necessary for structure determination by X-ray *** NMR spectroscopy,in addition to answering many unique structural biology questions that can be addressed specifically by that technique,can be exceedingly powerful in modern structural biology when combined with other techniques including X-ray crystallography and cryo-electron microscopy.

关键词： NMR spectroscopy X-ray crystallography structural biology protein complex assembly

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Mesophasic Assembly of Inhibitory Postsynaptic Density

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neuroscience Bulletin 2021年第1期37卷 141-143页

作者： Guanhua Bai Mingjie Zhang division of life science State Key Laboratory of Molecular NeuroscienceHong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of life sciences Southern University of Science and TechnologyShenzhen 518055China

Neurotransmitter receptors are concentrated in a morphological specialization of synapses known as the postsynaptic density (PSD).A prominent PSD beneath the postsynaptic membrane in electron micrographs is a defining feature of excitatory ***,the excitatory PSD (ePSD) has a disc-like shape 200-800 nm in diameter and 20-50 nm in thickness [1].In contrast,the inhibitory synapse only has thickened postsynaptic membranes in classical EM studies [2,3],thus whether inhibitory synapses contain PSD-like structures has been debated for decades.A few years ago,Bi and colleagues characterized the ultrastructure of excitatory and inhibitory synapses in cultured neurons by cryo-electron tomography(cryo-ET) and their high-resolution tomograms clearly showed electron-dense assemblies in both excitatory and inhibitory synapses [4].

关键词： beneath thick concentrated

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Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis

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neuroscience Bulletin 2018年第1期34卷 200-207页

作者： Changlin Li Sashuang Wang Yan Chen Xu Zhang Institute of neuroscience and state key laboratory of neuroscience Center for Excellence in Brain ScienceChinese Academy of Sciences School of life science and Technology ShanghaiTec University

Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion （DRG） neurons, and the generated inputs are transmitted via afferent fibers into the central nervous system. The gene expression profiles of DRG neurons contribute to the generation, transmission, and regulation of various somatosensory signals. Recently, the single-cell transcriptomes, cell types, and functional annotations of somatosensory neurons have been studied. In this review, we introduce our classification of DRG neurons based on single-cell RNA-sequencing and functional analyses, and discuss the technical approaches. Moreover, studies on the molecular and cellular mechanisms underlying somatic sensations are discussed.

关键词： Neuron type Single-cell technology Somatosensory mechanism Pain Gene profiles

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Calcium signaling during the early meroblastic cleavages of zebrafish and medaka embryos

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Frontiers in Biology 2010年第4期5卷 283-285页

作者： Andrew L.MILLER Section of Biochemistry and Cell Biology and State Key Laboratory for Molecular NeuroscienceDivision of Life ScienceHong Kong University of Science and TechnologyHong KongChina

The regulation of cytokinesis in“giant”embryonic cells(i.e.,>500μm in diameter)presents exacting challenges that include long-range signaling with respect to time and space;the transport and assembly,followed by disassembly,of an extensive contractile apparatus;and the remodeling and addition of new surface membrane to the resulting daughter cells.

关键词： fish daughter apparatus

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A facile design for multifunctional AIEgen based on tetraaniline derivatives

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science China Chemistry 2019年第6期62卷 732-738页

作者： Beibei Liu Wei He Hao Lu Kun Wang Mingming Huang Ryan Tsz Kin Kwok Jacky Wing Yip Lam Longcheng Gao Jiping Yang Benzhong Tang key laboratory of Aerospace Advanced Materials and Performance Ministry of Education School of Materials Science and EngineeringBeihang University Department of Chemistry HKUST Jockey Club Institute for Advanced Study Institute of Molecular Functional Materials Division of Biomedical Engineering State Key Laboratory of Molecular Neuroscience Division of Life Science The Hong Kong University of Science and Technology laboratory of Bio-Inspired Smart Interfacial science and Technology of Ministry of Education Key Laboratory of Beijing Energy School of Chemistry and Environment Beihang University

Aniline oligomers have been widely used in many fields due to their excellent physicochemical properties. Owing to strong intermolecular interactions, their emission is always weakened or quenched when they are in high concentration or aggregated state, which greatly limits their fluorescent applications. Inspired by the concept of aggregation-induced emission(AIE), herein we introduced large steric groups onto the aniline oligomer to prevent the formation of packing structure. In particular, diphenyl vinyl group was bonded with oligomeric tetraaniline by a facile synthetic procedure with high yield. The obtained aniline oligomer derivative exhibited typical AIE features, which was also confirmed by density functional theoretical calculation. More importantly, this AIE oligomer was able to detect Fe^(3+) ions selectively and quantitatively. The fluorescence intensity decreased linearly along with the increment of Fe^(3+) concentration. Moreover, we demonstrated that this AIE oligomer could stain live bacteria, such as E. coli and S. aureus efficiently. All these results suggest that such a readily accessible and multifunctional tetraaniline derivative provides a new platform for the construction of fluorescent materials.

关键词： tetraaniline aggregation-induced emission Fe3+ ion detection bacteria imaging

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