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Human immunodeficiency virus-associated dementia complex with positive 14-3-3 protein in cerebrospinal fluid:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2065-2073页

作者： Yun-Sen He Xiao-Hong Qin Min Feng Qin-Jiang Huang Meng-Jun Zhang Li-Li Guo Ming-Bin Bao Ye Tao Hong-Yuan Dai Bo Wu Department of Neurosurgery Sichuan Lansheng Brain Hospital&Shanghai Lansheng Brain Hospital Investment Co.Ltd.Chengdu 610036Sichuan ProvinceChina Department of Psychiatry Sichuan Provincial Center for Mental HealthChengdu 610072Sichuan ProvinceChina Department of Geriatrics Municipal People’s Hospital in LuzhouLuzhou 646000Sichuan ProvinceChina Department of Neurosurgery Wenjiang District People’s Hospital of ChengduChengdu 611100Sichuan ProvinceChina Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China ChengduChengdu 610072Sichuan ProvinceChina Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-associated dementia(HAD)is a subcortical form of dementia characterized by memory deficits and psychomotor ***,HAD often presents with symptoms similar to those of Creutzfeldt-Jakob disease(CJD),particularly in patients with acquired immune deficiency syndrome(AIDS).CASE SUMMARY We report the case of a 54-year-old male who exhibited cognitive dysfunction and secondary behavioral changes following HIV infection and suspected prion *** patient was diagnosed with HIV during hospitalization and his cerebrospinal fluid tested positive for 14-3-3 *** electroencephalogram showed a borderline-abnormal periodic triphasic wave ***-enhanced magnetic resonance imaging revealed moderate encephalatrophy and ***,symptomatic treatment and administration of amantadine were pursued for presumed CJD,but the patient’s condition continued to *** contrast,the patient’s condition improved following anti-HIV *** individual is also the only patient with this prognosis to have survived over 4 ***,the diagnosis was revised to *** In the diagnostic process of rapidly progressive dementia,it is crucial to rule out as many potential causes as possible and to consider an autopsy to diminish diagnostic *** 14-3-3 protein should not be regarded as the definitive marker for *** laboratory screening for infectious diseases is essential to enhance diagnostic precision,especially in AIDS patients with potential ***,a trial of diagnostic treatment may be considered when additional testing is not feasible.

关键词： HIV-associated dementia Cognitive dysfunction Creutzfeld-Jakob disease Rapidly progressive dementia Case report

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Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing

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Journal of Biomedical Research 2024年第4期38卷 358-368页

作者： Yifei Cheng Rongjie Shi Shuai Ben Silu Chen Shuwei Li Junyi Xin Meilin Wang Gong Cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Cancer hospital Jiangsu Institute of Cancer Researchthe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009China The Affiliated Suzhou hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China

The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the *** first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc *** then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA *** the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell ***,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting *** conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.

关键词： genetic variants prostate cancer circRNA RNA-binding protein RNA splicing sing-cell RNA sequencing

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The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury

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Neural Regeneration Research 2024年第5期19卷 1084-1091页

作者： Yijing Zhao Tong Li Zige Jiang Chengcheng Gai Shuwen Yu Danqing Xin Tingting Li Dexiang Liu Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao UniversityJinanShandong ProvinceChina

We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal ***,the precise mechanism underlying the role of H2S in this situation remains *** this study,we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine,a H2S precursor,attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionineβsynthase(a major H2S synthetase in the brain)in the prefrontal *** also found that an miR-9-5p inhibitor blocked the expression of cystathionineβsynthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ***,miR-9-5p overexpression increased cystathionine-β-synthase and H2S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury.L-cysteine decreased the expression of CXCL11,an miR-9-5p target gene,in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIP3,FSTL1,SOCS2 and SOCS5,while treatment with an miR-9-5p inhibitor reversed these *** findings suggest that H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoringβ-synthase expression,thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury.

关键词： chemokine(C-X-C motif)ligand 11 cystathionineβsynthase H2S hypoxic ischemic brain injury inflammation L-cysteine lipopolysaccharide microglia miR-9-5p neuroprotection

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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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Burden of gastrointestinal cancers among working-age population over past thirty years in China

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3955-3979页

作者： Yu Dong Zhuan-Zhuan Fan Wen-Ting Li Jian Kang Yan Zhang Yue Guan Hui-Qing Xu Jie Yuan Fei Xu Department of Gastroenterology Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Primary Healthcare Management Nanjing Municipal Center for Disease Control and PreventionNanjing 210003Jiangsu ProvinceChina Department of Emergency The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Epidemiology Nanjing Medical University School of Public HealthNanjing 211116Jiangsu ProvinceChina

BACKGROUND Although gastrointestinal(GI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of GI cancers in the working-age *** To assess the burden of GI cancers and to examine the overall,age-and genderspecific trends among the working-age population in China from 1990 to *** Data were extracted from the Global Burden of Disease Study *** burden of GI cancers was indicated by incidence,mortality,disability-adjusted life-years(DALYs),age-standardized incidence rate(ASIR),age-standardized mortality rate,and age-standardized DALYs *** in the burden of GI cancers from 1990 to 2019 were examined using annual percent change and average annual percent change with Joinpoint regression *** For overall GI cancers,a declining trend was observed in the ASIR,age-standardized mortality rate,and agestandardized DALYs rate,with reductions of 0.74%,2.23%,and 2.22%,respectively,from 1999 to 2019 in the Chinese working-age ***,an increasing trend was observed in the ASIR for overall GI cancers from *** number of either incident cases,mortality cases,and DALYs was higher for colon/rectum cancer and liver cancer in younger participants but lower for esophageal,gallbladder,biliary tract,pancreatic,and stomach cancer among older ***,sex disparity in the GI cancers burden was also examined over 30 *** The total burden of GI cancers remained heavy among the working-age population in China,although declining trends were observed from 1999 to *** in the GI cancers burden existed between sexes,age groups,and cancer ***-based precision prevention strategies are needed to tackle GI cancers among working-age individuals,considering the age,sex,and cancer type disparities in China.

关键词： Gastrointestinal cancer Working-age population Disease burden Disability-adjusted life-years Chinese

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Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN Fu-xin SU Jin-ye ZHUO Ling-yunn ZHU Qing SUN Xiao-chuan JIANG Rong-cai YAO Zhi-gang WANG Lei DANG Yan-wei LIU De-zhong LIU Yang FANG Wen-hua WANG Fang-yu LIN Yuan-xiang WANG An-xin WANG Deng-liang KANG De-zhi Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China Department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China Department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China Department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China Department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China Department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China Department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China Department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing municipal Key Laboratory of Clinical

Objective To investigate whether Naoxueshu Oral Liquid(NXS)could promote hematoma absorption in post-craniotomy hematoma(PCH)*** This is an open-label,multicenter,and randomized controlled trial conducted at 9 hospitals in *** aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL,or intraventricular hemorrhage following cranial surgery were *** were randomly assigned at a 1:1 ratio to the NXS(10 mL thrice daily for 15 days)or control groups using a randomization code *** medical care was administered in both *** primary outcome was the percentage reduction in hematoma volume from day 1 to day *** secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7,the absolute reduction in hematoma volume from day 1 to day 7 and 15,and the change in neurological function from day 1 to day 7 and *** safety was closely monitored throughout the ***,subgroup analysis was performed based on age,gender,history of diabetes,and etiology of intracerebral hemorrhage(ICH).Results A total of 120 patients were enrolled and randomly assigned between March 30,2018 and April 15,*** patient was lost to follow-up in the control ***,there were 119 patients(60 in the NXS group and 59 in the control group)included in the *** the full analysis set(FAS)analysis,the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group[median(Q1,Q3):85%(71%,97%)vs.76%(53%,93%),P0.05).Furthermore,no adverse events were reported during the *** the FAS analysis,the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:male patients,patients younger than 65 yea

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

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Prognostic value and predictive model of tumor markers in stageⅠtoⅢgastric cancer patients

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World Journal of Clinical Oncology 2024年第8期15卷 1033-1047页

作者： Ai-Hua Sun Xin-Yu Zhang Yang-Yang Huang Lei Chen Qing Wang Xiao-Cong Jiang Department of Radiotherapy Oncology Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina Department of Hepatobiliary Surgery Fujian Provincial HospitalFuzhou 350001China Department of General Surgery Xiang'an Hospital of Xiamen UniversityXiamen 361102Fujian ProvinceChina

BACKGROUND Preoperative serum tumor markers have been widely used in the diagnosis and treatment of gastric cancer ***,few studies have evaluated the prognosis of gastric cancer patients by establishing statistical models with multiple serum tumor *** To explore the prognostic value and predictive model of tumor markers in stage I and III gastric cancer *** From October 2018 to April 2020,a total of 1236 patients with stage I to III gastric cancer after surgery were included in our *** relationship between serum tumor markers and clinical and pathological data were *** established a statistical model to predict the prognosis of gastric cancer based on the results of COX regression *** survival(OS)was also compared across different stages of gastric *** The deadline for follow-up was May 31,2023.A total of 1236 patients were included in our *** analysis found that age,clinical stage,T and N stage,tumor location,differentiation,Borrmann type,size,and four serum tumor markers were prognostic factors of OS(P<0.05).It was shown that clinical stage,tumor size,alpha foetoprotein,carcinoembryonic antigen,CA125 and CA19-9(P<0.05)were independent prognostic factors for *** to the scoring results obtained from the statistical model,we found that patients with high scores had poorer survival time(P<0.05).Furthermore,in stage I patients,the 3-year OS for scores 0-3 ranged from 96.85%,95%,85%,and 80%.In stage II patients,the 3-year OS for scores 0-4 were 88.6%,76.5%,90.5%,65.5%and 60%.For stage III patients,3-year OS for scores 0-6 were 70.9%,68.3%,64.1%,50.9%,38.4%,18.5%and 5.2%.We also analyzed the mean survival of patients with different *** stage I patients,the mean OS was 55.980 *** stage II,the mean OS was 51.550 *** mean OS for stage III was 39.422 *** Our statistical model can effectively predict the prognosis of gastric cancer patients.

关键词： Gastric cancer Tumor marker Prognosis Overall survival Model

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Future directions:combination of acupuncture with mesenchymal stem cells for Parkinson’s disease

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Integrative Medicine Discovery 2024年第23期8卷 1-6页

作者： Shan Zhong Song-Zhe He Xi-Lin Wang Department of Acupuncture and Moxibustion Guilin Municipal Hospital of Traditional Chinese MedicineGuangxi University of Chinese MedicineGuilin 541002China Department of Clinic Laboratory Affiliated Hospital of Guilin Medical UniversityGuilin 541001China.

Parkinson’s disease(PD)is a progressive chronic disease currently with no radical cure drugs and means due to the complex pathological mechanisms and limited regenerative capacity of *** aids in neuronal regeneration via various signaling routes like ROCK,Wnt,and Notch,safeguarding dopaminergic neurons against inflammation,oxidative stress,and cell death,which in turn enhances the progression of PD *** research findings indicate that integrating acupuncture with mesenchymal stem cells(MSCs)transplantation is more effective than using either acupuncture or MSCs infusion *** combined treatment improves the survival rate of MSCs,promotes the generation of functional neural networks by stimulating the secretion of neurotrophic factors,and ultimately improves the disease *** this review,we state the neuroprotective effects of acupuncture or MSCs treament alone in PD,then summarize the application of acupuncture combined with MSCs therapy in other ***,we anticipate that integrating acupuncture with MSCs transplantation may emerge as a novel and efficient approach for managing *** possibility needs to be verified through further basic and clinical research.

关键词： Parkinson’s disease acupuncture mesenchymal stem cells dopaminergic neuron therapy

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Influence of perinatal factors on full-term low-birth-weight infants and construction of a predictive model

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World Journal of Clinical Cases 2024年第26期12卷 5901-5907页

作者： Liang Xu Xue-Juan Sheng Lian-Ping Gu Zu-Ming Yang Zong-Tai Feng Dan-Feng Gu Li Gao Department of Neonatology Suzhou Ninth People's HospitalSuzhou 215200Jiangsu ProvinceChina Department of Obstetrics Suzhou Ninth People's HospitalSuzhou 215200Jiangsu ProvinceChina Department of Neonatology Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina

BACKGROUND Being too light at birth can increase the risk of various diseases during *** To explore the effect of perinatal factors on term low-birth-weight(LBW)infants and build a predictive *** model aims to guide the clinical management of pregnant women’s healthcare during pregnancy and support the healthy growth of *** A retrospective analysis was conducted on data from 1794 single full-term pregnant women who gave *** were grouped based on birth weight:Those with birth weight<2.5 kg were classified as the low-weight group,and those with birth weight between 2.5 kg and 4 kg were included in the normal *** logistic regression analysis was used to identify the factors influencing the occurrence of full-term LBW.A risk prediction model was established based on the analysis *** effectiveness of the model was analyzed using the Hosmer–Leme show test and receiver operating characteristic(ROC)curve to verify the accuracy of the *** Among the 1794 pregnant women,there were 62 cases of neonatal weight<2.5 kg,resulting in an LBW incidence rate of 3.46%.The factors influencing full-term LBW included low maternal education level[odds ratio(OR)=1.416],fewer prenatal examinations(OR=2.907),insufficient weight gain during pregnancy(OR=3.695),irregular calcium supplementation during pregnancy(OR=1.756),and pregnancy hypertension syndrome(OR=2.192).The prediction model equation was obtained as follows:Logit(P)=0.348×maternal education level+1.067×number of prenatal examinations+1.307×insufficient weight gain during pregnancy+0.563×irregular calcium supplementation during pregnancy+0.785×pregnancy hypertension syndrome−*** area under the ROC curve for this model was 0.853,with a sensitivity of 0.852 and a specificity of *** Hosmer–Leme show test yieldedχ^(2)=2.185,P=0.449,indicating a good *** overall accuracy of the clinical validation model was 81.67%.CONCLUSION The occurrence of full-te

关键词： Pregnant women Perinatal care Low-birth-weight infants Influencing factors Prediction model

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Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

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Stroke & Vascular Neurology 2024年第1期9卷 50-58页

作者： Yang Zhao Junlin Lu Hongqi Zhang Tianxiao LI Donglei Song Sheng Guan Aisha Maimaitili Yunyan Wang Wenfeng Feng Yang Wang Jieqing Wan Guohua Mao Huaizhang Shi Xinjian Yang Jianmin Liu Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Zhengzhou University People's HospitalZhengzhouHenanChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Interventional Neuroradiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina

Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for *** study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world *** We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect *** study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect *** analyses by aneurysm location,size and form were also *** This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms<10mm and saccular *** Our data confirmed the efficacy of PED in relieving mass *** findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial *** registration number NCT03831672.

关键词： aneurysm intracranial Irvine

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