Prognostic value and predictive model of tumor markers in stageⅠtoⅢgastric cancer patients
作者机构：Department of Radiotherapy OncologyHuizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina Department of Hepatobiliary SurgeryFujian Provincial HospitalFuzhou 350001China Department of General SurgeryXiang'an Hospital of Xiamen UniversityXiamen 361102Fujian ProvinceChina
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2024年第15卷第8期
页 面：1033-1047页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Gastric cancer Tumor marker Prognosis Overall survival Model
摘 要：BACKGROUND Preoperative serum tumor markers have been widely used in the diagnosis and treatment of gastric cancer ***,few studies have evaluated the prognosis of gastric cancer patients by establishing statistical models with multiple serum tumor *** To explore the prognostic value and predictive model of tumor markers in stage I and III gastric cancer *** From October 2018 to April 2020,a total of 1236 patients with stage I to III gastric cancer after surgery were included in our *** relationship between serum tumor markers and clinical and pathological data were *** established a statistical model to predict the prognosis of gastric cancer based on the results of COX regression *** survival(OS)was also compared across different stages of gastric *** The deadline for follow-up was May 31,2023.A total of 1236 patients were included in our *** analysis found that age,clinical stage,T and N stage,tumor location,differentiation,Borrmann type,size,and four serum tumor markers were prognostic factors of OS(P0.05).It was shown that clinical stage,tumor size,alpha foetoprotein,carcinoembryonic antigen,CA125 and CA19-9(P0.05)were independent prognostic factors for *** to the scoring results obtained from the statistical model,we found that patients with high scores had poorer survival time(P0.05).Furthermore,in stage I patients,the 3-year OS for scores 0-3 ranged from 96.85%,95%,85%,and 80%.In stage II patients,the 3-year OS for scores 0-4 were 88.6%,76.5%,90.5%,65.5%and 60%.For stage III patients,3-year OS for scores 0-6 were 70.9%,68.3%,64.1%,50.9%,38.4%,18.5%and 5.2%.We also analyzed the mean survival of patients with different *** stage I patients,the mean OS was 55.980 *** stage II,the mean OS was 51.550 *** mean OS for stage III was 39.422 *** Our statistical model can effectively predict the prognosis of gastric cancer patients.
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