Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

作     者：Yang Zhao Junlin Lu Hongqi Zhang Tianxiao LI Donglei Song Sheng Guan Aisha Maimaitili Yunyan Wang Wenfeng Feng Yang Wang Jieqing Wan Guohua Mao Huaizhang Shi Xinjian Yang Jianmin Liu Yuanli Zhao 

作者机构：Department of NeurosurgeryBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of NeurosurgeryPeking University International HospitalBeijingChina Department of NeurosurgeryWest China HospitalSichuan UniversityChengduSichuanChina Department of NeurosurgeryXuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional NeuroradiologyZhengzhou University People's HospitalZhengzhouHenanChina Department of NeurosurgeryShanghai Donglei Brain HospitalShanghaiChina Department of Interventional NeuroradiologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of NeurosurgeryThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of NeurosurgeryQilu Hospital of Shandong University QingdaoJinanShandongChina Department of NeurosurgeryNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of NeurosurgeryThe First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of NeurosurgeryRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of NeurosurgeryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of NeurosurgeryThe First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of NeurosurgeryChanghai HospitalNaval Medical UniversityShanghaiChina 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2024年第9卷第1期

页      面：50-58页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：sponsored by the National Natural Science Foundation of China(82071302) Bai Qian Wan Talent Plan(2017A07)and Beijing Municipal Administration of Hospital Incubating Program(PX2016034) 

主　　题：aneurysm intracranial Irvine 

摘      要：Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for *** study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world *** We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect *** study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect *** analyses by aneurysm location,size and form were also *** This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms10mm and saccular *** Our data confirmed the efficacy of PED in relieving mass *** findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial *** registration number NCT03831672.