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MRI versus 64-row MDCT for diagnosis of hepatocellular carcinoma

World Journal of Gastroenterology 2009年第48期15卷 6044-6051页

作者： Michael Bernhard Pitton Roman Kloeckner Sascha Herber Gerd Otto Karl Friedrich Kreitner Christoph Dueber Department of diagnostic and Interventional radiology Johannes Gutenberg-University Department of Transplantation and Hepatobili-opancreatic Surgery University of Mainz

AIM： To compare the diagnostic capability of multidetector computed tomography （MDCT） and magnetic resonance imaging （MRI） for the detection of hepatocellular carcinoma （HCC） tumour nodules and their effect on patient management. METHODS： A total of 28 patients （25 male, 3 female, mean age 67 ± 10.8 years） with biopsy-proven HCC were investigated with 64-row MDCT （slice 3 mm native, arterial and portal-venous phase, 120 mL Iomeprol, 4 mL/s, delay by bolus trigger） and MRI （Tlfs fl2d TE/ TR 2.72/129 ms, T2tse TE/TR 102/4000 ms, 5-phase dynamic contrast-enhanced Tlfs fl3d TE/TR 1.56/4.6, Gadolinium-DTPA, slice 4 mm）. Consensus reading of both modalities was used as reference. Tumour nodules were analyzed with respect to number, size, and location. RESULTS： In total, 162 tumour nodules were detected by consensus reading. MRI detected significantly more tumour nodules （159 vs 123, P 〈 0.001） compared to MDCT, with the best sensitivity for early arterial phase MRI. False-negative CT findings included nodules ≤ 5 mm （n = 5）, ≤ 10 mm （n = 17）, ≤ 15 mm （n= 12）,≤20mm（n=4）,andlnodule〉*** missed 2 nodules ≤ 10 mm and 1 nodule ≤ 15 mm. On MRI, nodule diameters were greater than on CT （29.2 ≤25.1 mm, range 5-140 mm vs 24.1 ± 22.7 mm, range 4-129 mm, P 〈 0.005）. In 2 patients, MDCT showed only unilobar tumour spread, whereas MRI revealed additional nodules in the contralateral lobe. Detection of these nodules could have changed the therapeutic strategy. CONCLUSION： Contrast-enhanced MRI is superior to 64-row MDCT for the detection of HCC nodules. Patients should be allocated to interventional or operative treatment according to a dedicated MRI-protocol.

关键词： American Association for the Study of Liver Diseases European Association for the Study of the Liver Hepatocellular carcinoma Multidetector computed tomography Magnetic resonance imaging

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Advances and effectiveness of the immunotherapy after liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 629-631页

作者： Sai Swarupa R Vulasala Nirmal K Onteddu Sindhu P Kumar Chandana Lall Priya Bhosale Mayur K Virarkar Department of radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Internal Medicine Flowers HospitalDothanAL 36305United States Division of diagnostic imaging Department of Diagnostic RadiologyThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

Transplant recipients usually have increased chances of graft rejection and graft vs host disease,requiring chronic immunosuppressive ***,longterm immunosuppression risks malignancies such as skin cancer,lymphoma,and Kaposi ***,there are very few studies that included solid organ transplant recipients while studying the efficacy of immunotherapy.“Immunotherapy after liver transplantation:Where are we now?”is a study,where the authors described the mechanism of action and outcomes of immune checkpoint inhibitors specific to liver transplant *** authors reported the graft rejection rates and the factors contributing to the rejection in the liver transplant recipients.

关键词： Immunotherapy Hepatocellular carcinoma Immune checkpoint inhibitors Liver transplantation Solid organ transplant Graft rejection

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An In Vivo Proton MR Spectroscopy Study of Late Delayed Radiation Necrosis at the Temporal Lobes in Patients Treated for Nasopharyngeal Carcinoma

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临床医学工程 1998年第3期 85-87页

作者： D.Yeung,Y.L.Chan,S.F.Leung,W.W.MLam,G.Cao~#,C.Metreweli Prince of Wales Hospital Chinese University of Hong Kong Depts. of diagnostic radiology and organ imaging and Clinical Oncology Shatin Philips Medical Systems~# Hong Kong Prince of Wales Hospital Chinese University of Hong Kong Depts. of diagnostic radiology and organ imaging and Clinical Oncology Shatin Philips Medical Systems~# Hong Kong Prince of Wales Hospital Chinese University of Hong Kong Depts. of diagnostic radiology and organ imaging and Clinical Oncology Shatin Philips Medical Systems~# Hong Kong Prince of Wales Hospital Chinese University of Hong Kong Depts. of diagnostic radiology and organ imaging and Clinical Oncology Shatin Philips Medical Systems~# Hong Kong Prince of Wales Hospital Chinese University of Hong Kong Depts. of diagnostic radiology and organ imaging and Clinical Oncology Shatin Philips Medical Systems~# Hong Kong Prince of Wales Hospital Chinese University of Hong Kong Depts. of diagnostic radiology and organ imaging and Clinical Oncology Shatin Philips Medical Systems~# Hong Kong

Introduction Nasopharyngeal carcinoma （NPC） is an epithelial-originated malignancy occuning with a high incidence in Southeast Asia, in particulat, in southern China. The molecular basis for the disease is not well understood and recent epidemiology studies have correlated the disease to Epstein-Barr virus （EBV） infection, consumption of salted fish, preserved foods and smoking'. NPC is almost entirely of the undiffenentiated squamous cell types and the discase is highly curable by radiation therapy, with survival rates of 80-90％2. Despite this high disease-free survival race, the long term overall survival rate is not so good3because of late delayed radiation comphcations, Late delayed radiation injury, which

关键词： MR An In Vivo Proton MR Spectroscopy Study of Late Delayed Radiation Necrosis at the Temporal Lobes in Patients Treated for Nasopharyngeal Carcinoma

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Post-operative imaging in liver transplantation: State-of-the-art and future perspectives

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World Journal of Gastroenterology 2014年第20期20卷 6180-6200页

作者： Rossano Girometti Giuseppe Como Massimo Bazzocchi Chiara Zuiani Department of Medical and Biological Sciences Institute of Diagnostic Radiology University of Udine 33100 Udine Italy

Orthotopic liver transplantation(OLT)represents a major treatment for end-stage chronic liver disease,as well as selected cases of hepatocellular carcinoma and acute liver *** ever-increasing development of imaging modalities significantly contributed,over the last decades,to the management of recipients both in the pre-operative and post-operative period,thus impacting on graft and patients *** properly used,imaging modalities such as ultrasound,multidetector computed tomography,magnetic resonance imaging(MRI)and procedures of direct cholangiography are capable to provide rapid and reliable recognition and treatment of vascular and biliary complications occurring after *** defined is the role for imaging in assessing primary graft dysfunction(including rejection)or chronic allograft disease after OLT,e.g.,hepatitis C virus(HCV)*** paper:(1)describes specific characteristic of the above imaging modalities and the rationale for their use in clinical practice;(2)illustrates main imaging findings related to post-OLTcomplications in adult patients;and(3)reviews future perspectives emerging in the surveillance of recipients with HCV recurrence,with special emphasis on MRI.

关键词： Orthotopic liver transplantation Ultrasound Computed tomography Magnetic resonance imaging T-tube cholangiography Endoscopic retrograde cholangiography Percutaneous transhepatic cholangiography Orthotopic liver transplantation complications Human C virus recurrence

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从信号到知识——基于人工智能的医学影像裸数据诊断价值初探

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Engineering 2024年第3期34卷 60-69页

作者： Bingxi He Yu Guo Yongbei Zhu Lixia Tong Boyu Kong Kun Wang Caixia Sun Hailin Li Feng Huang Liwei Wu Meng Wang Fanyang Meng Le Dou Kai Sun Tong Tong Zhenyu Liu Ziqi Wei Wei Mu Shuo Wang Zhenchao Tang Shuaitong Zhang Jingwei Wei Lizhi Shao Mengjie Fang Juntao Li Shouping Zhu Lili Zhou Shuo Wang Di Dong Huimao Zhang Jie Tian Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Engineering MedicineBeihang UniversityBeijing 100191China Key Laboratory of Big Data-Based Precision Medicine Beihang UniversityMinistry of Industry and Information TechnologyBeijing 100191China CAS Key Laboratory of Molecular imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of radiology The First Hospital of Jilin UniversityChangchun 130021China Neusoft Medical Systems Co.Ltd. Shenyang 110167China Neusoft Research of Intelligent Healthcare Technology Co.Ltd. Shenyang 110167China School of Life Science and Technology Xidian UniversityXi’an 710126China Engineering Research Center of Molecular and Neuro imaging Ministry of EducationXi’an 710126China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

Encouraging and astonishing developments have recently been achieved in image-based diagnostic *** medical care and imaging technology are becoming increasingly ***,the current diagnosis pattern of signal to image to knowledge inevitably leads to information distortion and noise introduction in the procedure of image reconstruction(from signal to image).Artificial intelligence(AI)technologies that can mine knowledge from vast amounts of data offer opportunities to disrupt established *** this prospective study,for the first time,we develop an AI-based signal-toknowledge diagnostic scheme for lung nodule classification directly from the computed tomography(CT)raw data(the signal).We find that the raw data achieves almost comparable performance with CT,indicating that it is possible to diagnose diseases without reconstructing ***,the incorporation of raw data through three common convolutional network structures greatly improves the performance of the CT models in all cohorts(with a gain ranging from 0.01 to 0.12),demonstrating that raw data contains diagnostic information that CT does not *** results break new ground and demonstrate the potential for direct signal-to-knowledge domain analysis.

关键词： Computed tomography Diagnosis Deep learning Lung cancer Raw data

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A NEAR-INFRARED FLUORESCENT DEOXYGLUCOSE DERIVATIVE FOR OPTICAL imaging OF EXPERIMENTAL ARTHRITIS

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Journal of Innovative Optical Health Sciences 2009年第2期2卷 179-187页

作者： XIUPING LIU ZHENGMING XIONG SHEEN-WOO LEE JELENA LEVI SHAHRIAR YAGHOUBI SANDIP BISWAL SANJIV SAM GAMBHIR ZHEN CHENG School of Life Science&Technology Huazhong University of Science and Technology Wuhan 430074 China Molecular imaging Program at Stanford(MIPS)departments of radiology and Bioengineering Bio-X Program Stanford UniversityCalifornia 94305USA

The purpose of this study is to investigate whether a near-infrared fluorescence(NIRF)probe,Cy5.5-d-glucosamine(Cy5.5-2DG),can image arthritis in collagen-induced arthritic(CIA)*** presence of arthritis was verified by both visual examination and micro-computed tomography(MicroCT)*** mice were imaged by a micro-positron emission tomography(MicroPET)scanner one hour after intravenous injection of 2-deoxy-2-[18F]fluoro-d-glucose([18F]FDG).After radioactivity of[18F]FDG decayed away,Cy5.5-2DG was injected into a lateral tail vein of the *** tissue targeting and retention of Cy5.5-2DG in CIA mice were evaluated and quantified by an optical imaging *** tissue in CIA mice was clearly visualized by[18F]FDG-MicroPET *** imaging of Cy5.5-2DG in the same mice revealed that the pattern of localization of Cy5.5-2DG in the arthritic tissue was very similar to that of[18F]*** analysis further showed that[18F]FDG uptake in arthritic tissues at one hour post-injection(p.i.)and Cy5.5-2DG uptakes at different time points *** all well correlated(r2 over 0.65).In conclusion,Cy5.5-DG can detect arthritic tissues in living *** good correlation between the[18F]FDG uptake and Cy5.5-2DG accumulation in the same arthritic tissue warrants further investigation of Cy5.5-2DG as an approach for assessment of anti-inflammatory treatments.

关键词： Near-infrared fluorescence arthritis fluorescent deoxyglucose FDG

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Ductal carcinoma in situ within a fibroadenoma:A case report and review of literature

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World Journal of radiology 2024年第3期16卷 58-68页

作者： Yazmin Olivares-Antúnez Yesika Janett Dávila-Zablah JoséRaúl Vázquez-Ávila Gabriela Sofía Gómez-Macías María Teresa Mireles-Aguilar Margarita Lilia Garza-Montemayor Department of diagnostic Breast imaging Center Hospital Zambrano HellionTecnológico de MonterreyNuevo León 66260Mexico Department of Patology Service Hospital San JoséTecnológico de MonterreyNuevo León 64710Mexico Department of Faculty of Medicine Hospital Universitario de la UANLNuevo León 64710Mexico. Department of Breast Surgery Center Hospital Zambrano HellionTecnológico de MonterreyNuevo León 66260Mexico

BACKGROUND Fibroadenoma(FA)is the most common tumor found in young women,although it can occur in any age *** carcinoma in situ(DCIS)that is confined in a FA is rare;it is most frequently reported as an incidental *** SUMMARY We report a case of DCIS within a FA in a 46-year-old female without cancerrelated personal and family *** patient was diagnosed with a breast conglomerate of nodules and was followed for 1 *** the current control image study,we found suspicious microcalcification,as a new finding,within one of the ***,a core biopsy of the tumor,which appeared hypoechoic,oval,and circumscribed,was *** pathological diagnosis was ductal carcinoma in situ within a fibroepithelial *** patient underwent breastconserving surgery and received radiotherapy as well as endocrine therapy(tamoxifen).CONCLUSION We recommend a multidisciplinary approach for adequate treatment and followup.

关键词： Carcinoma in situ Fibroadenoma Mammography Ultrasound Magnetic resonance imaging radiology Case report

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Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer

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World Journal of Gastroenterology 2020年第20期26卷 2657-2668页

作者： Davide Ippolito Silvia Girolama Drago Anna Pecorelli Cesare Maino Giulia Querques Ilaria Mariani Cammillo Talei Franzesi Sandro Sironi Department of diagnostic radiology H.S.Gerardo MonzaSan Gerardo HospitalUniversity of Milano-BicoccaMonza 20900Italy Department of diagnostic radiology Papa Giovanni XXIII HospitalUniversity of Milano-BicoccaBergamo 20110Italy

BACKGROUND The management of rectal cancer patients is mainly based on the use of the magnetic resonance imaging(MRI)technique as a diagnostic tool for both staging and *** treatment,to date,the evaluation of complete response is based on the histopathology assessment by using different tumor regression grade(TRG)features(e.g.,Dworak or Mandard classifications).While from the radiological point of view,the main attention for the prediction of a complete response after chemotherapy treatment focuses on MRI and the potential role of diffusion-weighted images and perfusion imaging represented by dynamiccontrast enhanced *** main aim is to find a reliable tool to predict tumor response in comparison to histopathologic *** To investigate the value of dynamic contrast-enhanced perfusion-MRI parameters in the evaluation of the healthy rectal wall and tumor response to chemo-radiation therapy in patients with local advanced rectal cancer with histopathologic *** Twenty-eight patients with biopsy-proven rectal adenocarcinoma who underwent a dynamic contrast-enhanced MR study performed on a 1.5 T MRI system(Achieva,Philips),before(MR1)and after chemoradiation therapy(MR2),were enrolled in this *** protocol included T1 gadolinium enhanced THRIVE sequences acquired on axial planes.A dedicated workstation was used to generate color permeability *** of interest was manually drawn on tumor tissue and normal rectal wall,hence the following parameters were calculated and statistically analyzed:Relative arterial enhancement(RAE),relative venous enhancement(RVE),relative late enhancement(RLE),maximum enhancement(ME),time to peak and area under the curve(AUC).Perfusion parameters were related to pathologic TRG(Mandard’s criteria;TRG1=complete regression,TRG5=no regression).RESULTS Ten tumors(36%)showed complete or subtotal regression(TRG1-2)at histology and classified as responders;18 tumors(64%)were classified as non-responders(TR

关键词： Rectal neoplasm Chemotherapy Radiotherapy Tumor staging Treatment response Magnetic resonance imaging

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Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma

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World Journal of Gastroenterology 2003年第1期9卷 94-98页

作者： Jochen Truebenbach Florian Graepler Philippe Pereira Peter Huppert Thomas Eul Gundula Wiemann Claus Claussen Department of diagnostic radiology Eberhard-Karls-University TubingenHoppe-Seyler-Strasse-3Tubingen 72076Germany

AIM:To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide(PIcg)-microspheres in the transarterial chemoembolization (TACE) in ... 详细信息

关键词：肝细胞癌动物模型动脉灌注化疗栓塞介入治疗肿瘤抑制

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Multisystemic recurrent Langerhans cell histiocytosis misdiagnosed with chronic inflammation at the first diagnosis:A case report

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World Journal of radiology 2024年第6期16卷 232-240页

作者： Zhan-Rong Zhang Feng Chen Hui-Juan Chen Department of radiology The Affiliated Hainan Hospital of Hainan Medical University(Hainan General Hospital)Haikou 570311Hainan ProvinceChina

BACKGROUND Langerhans cell histiocytosis(LCH)is characterized by diabetes insipidus and is an uncommon *** biopsies still have a certain degree of diagnostic *** present a case in which LCH initially affected the pituitary *** resulted in a misdiagnosis of chronic inflammation upon pathological *** SUMMARY A 25-year-old female exhibited symptoms of diabetes *** resonance imaging revealed an enhanced foci in the pituitary *** surgical resection of the pituitary lesion,the pathological diagnosis was chronic ***,the patient later experienced bone destruction in the skull and lower limb *** the lower limb bone lesion was compared with the initial pituitary lesion,the final diagnosis was modified to *** patient was treated with multiple chemotherapy ***,the patient’s condition gradually worsened,and she eventually passed away at *** LCH should be considered when patients exhibit diabetes insipidus and absence of high signal intensity in the pituitary gland on sagittal T1-weighted image and abnormal enhancement in the pituitary region.

关键词： Langerhans cell histiocytosis Pituitary gland Diabetes insipidus Multi-system Misdiagnosis Magnetic resonance imaging Case report

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