A NEAR-INFRARED FLUORESCENT DEOXYGLUCOSE DERIVATIVE FOR OPTICAL IMAGING OF EXPERIMENTAL ARTHRITIS

作     者：XIUPING LIU ZHENGMING XIONG SHEEN-WOO LEE JELENA LEVI SHAHRIAR YAGHOUBI SANDIP BISWAL SANJIV SAM GAMBHIR ZHEN CHENG 

作者机构：School of Life Science&Technology Huazhong University of Science and Technology Wuhan 430074China Molecular Imaging Program at Stanford(MIPS)Departments of Radiology and BioengineeringBio-X Program Stanford UniversityCalifornia 94305USA 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2009年第2卷第2期

页      面：179-187页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foundation of China(Grant No.90508003) National Cancer Institute(NCI)Small Animal Imaging Resource Program(SAIRP)Grant R24 CA93862 NCI In Vivo Cellular Molecular Imaging Center(ICMIC)Grant P50 CA114747(SSG) 

主　　题：Near-infrared fluorescence arthritis fluorescent deoxyglucose FDG 

摘      要：The purpose of this study is to investigate whether a near-infrared fluorescence(NIRF)probe,Cy5.5-d-glucosamine(Cy5.5-2DG),can image arthritis in collagen-induced arthritic(CIA)*** presence of arthritis was verified by both visual examination and micro-computed tomography(MicroCT)*** mice were imaged by a micro-positron emission tomography(MicroPET)scanner one hour after intravenous injection of 2-deoxy-2-[18F]fluoro-d-glucose([18F]FDG).After radioactivity of[18F]FDG decayed away,Cy5.5-2DG was injected into a lateral tail vein of the *** tissue targeting and retention of Cy5.5-2DG in CIA mice were evaluated and quantified by an optical imaging *** tissue in CIA mice was clearly visualized by[18F]FDG-MicroPET *** imaging of Cy5.5-2DG in the same mice revealed that the pattern of localization of Cy5.5-2DG in the arthritic tissue was very similar to that of[18F]*** analysis further showed that[18F]FDG uptake in arthritic tissues at one hour post-injection(p.i.)and Cy5.5-2DG uptakes at different time points *** all well correlated(r2 over 0.65).In conclusion,Cy5.5-DG can detect arthritic tissues in living *** good correlation between the[18F]FDG uptake and Cy5.5-2DG accumulation in the same arthritic tissue warrants further investigation of Cy5.5-2DG as an approach for assessment of anti-inflammatory treatments.