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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li department of spleen and stomach diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

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Asian Pacific Journal of Tropical Medicine 2014年第5期7卷 402-406页

作者： Wei Gao Hai-Ying Li Li-Xin Wang Li-Jun Hao Jian-Li Gao Rong-Juan Zheng Chun-Jiang Cai Yan-Ling Si department of Gastroenterology Tangshan Workers' Hospital department of spleen and stomach Tangshan TCM Hospital

Objective:To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension ***:All rats were randomly divided into normal control group,cirrhosis and treatment *** was used to establish rat model of cirrhotic portal *** necrotic tissue of gastric mucosa ulcer focus,degree of neutrophils infiltration at the ulcer margin,portal pressure,portal venous flow,abdominal aortic pressure,abdominal aortic blood flow at front end,gastric mucosal blood flow（GMBF）,glycoprotein（GP）of gastric mucosa,basal acid secretion,H’ back-diffusion,gastric mucosal damage index,NO,prostaglandin E2（PGE2） and tumor necrosis factor-α（TNF-α） were determined respectively,and the pathological changes of gastric mucosa were also observed by ***:Compared with cirrhosis group and the control group,the ulcer bottom necrotic material,gastric neutrophil infiltration and UI of the treatment group were all decreased significantly（P<0.01）,GMBF value,GP values,serum NO,PGE2,TNF- a were all significantly ***:Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

关键词： Omeprazole Cirrhotic portal hypertension Gastric mucosal injury Prostaglandins Tumor necrosis factor-alpha

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Clinical effects of a traditional Chinese medicine nursing programme to intervene in gastric pain of the spleen and stomach with Qi deficiency

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World Journal of Clinical Cases 2023年第21期11卷 5056-5062页

作者： Yin-Hong Yu Yu-Shuang Yu Xiao-He Cheng spleen and stomach diseases department Zhejiang Province Chun’an County Traditional Chinese Medicine HospitalChun’an County 311700Zhejiang ProvinceChina

BACKGROUND Gastroparesis is a common digestive disorder characterized by delayed gastric emptying,which can lead to symptoms such as nausea,vomiting,abdominal pain,and poor *** Chinese medicine(TCM)has been used for centuries to treat gastrointestinal disorders,including *** theory suggests that spleen and stomach qi deficiency syndrome is one of the main pathogenic factors in *** care plays an important role in the treatment of gastroparesis,and TCM nursing interventions have shown promising results in improving patient ***,there is limited research on the clinical effectiveness of TCM nursing interventions for gastroparesis with spleen stomach deficiency *** study aimed to evaluate the clinical effect of TCM nursing intervention in the treatment of gastroparesis with spleen stomach deficiency syndrome and to compare it with routine nursing *** To analyze the clinical effect of traditional Chinese medicine nursing intervention in the treatment of gastric paraplegia with spleen stomach deficiency *** From January 2020 to July 2021,80 patients with gastroparesis of spleen stomach qi deficiency type diagnosed in our hospital were selected for the *** 80 patients were randomly divided into a control group and an experimental group,with 40 cases in each *** the treatment period,the control group received routine nursing interventions,while the experimental group received traditional Chinese medicine nursing *** the nursing effects of the two groups and observe the changes in traditional Chinese medicine symptom scores,pain levels,and sleep quality before and after *** After treatment,comparing the treatment effects of the two groups,the total effective rate of the experimental group was significantly higher than that of the control group,with statistical significance(P<0.05).There was no statistically significant difference in th

关键词： Chinese medicine nursing programme spleen and stomach qi deficiency type Gastric and epigastric pain Nursing effect Pain Sleep quality

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Treatment of constipation-predominant irritable bowel syndrome by focusing on the liver in terms of Traditional Chinese Medicine:a meta-analysis

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Journal of Traditional Chinese Medicine 2013年第5期33卷 562-571页

作者： Qianwen Li Fengbin Liu Zhengkun Hou Di Luo department of Chinese Medicine Health Care Guangdong Food and Drug Vocational College spleen-stomach diseases department FirstAffiliated Hospital of Guangzhou University of Chinese Medi-cine spleen-stomach Dis-eases department First Affiliated Hospital of GuangzhouUniversity of Chinese Medicine

OBJECTIVE:To assess the efficacy of Traditional Chinese Medicine(TCM)on constipation-predominant irritable bowel syndrome by focusing on the ***:Databases(domestic and foreign)were searched with the key words"irritable bowel syndrome","constipation",and"Chinese medicine";the relevant articles were retrieved and *** rate,"remarkable efficacy",recurrence rate and the incidence of adverse reactions were the outcome *** Manager ver 5.1 was used for this meta-analysis,and funnel plots used to detect publication ***:Nineteen randomized controlled trials were included and 1510 patients *** treatment guided byTCM based on the liver was superior to Western Medicine[odds ratio(OR)=2.46,95%confidence interval(CI)1.80,3.35)],cure rate[OR=2.61,95%CI(1.93,3.52)],remarkable efficacy[OR=2.68,95%CI(1.82,3.95)],recurrence rate[OR=0.19,95%CI(0.12,0.29)]and the incidence of adverse reactions[OR=0.24,95%CI(0.09,0.65)].However,funnel plots showed publication ***:Compared with Western Medicine,the treatment of IBS-C based on the liver is significantly better but the results must be treated with caution because publication bias was recorded.

关键词： Meta-analysis Medicine Chinese traditional Constipation Irritable bowel syndrome Randomized controlled trial

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5’tiRNA-Pro-TGG,a novel tRNA halve,promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 1005-1018页

作者： Xin-Yuan Wang Yu-Jie Zhou Hai-Ying Chen Jin-Nan Chen Shan-Shan Chen Hui-Min Chen Xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200000China department of spleen and stomach and Rheumatology Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Transfer RNA(tRNA)-derived small RNAs(tsRNAs)are small fragments that form when tRNAs *** halves(tiRNAs),a subcategory of tsRNA,are involved in the oncogenic processes of many ***,their specific role in sessile serrated lesions(SSLs),a precancerous lesion often observed in the colon,has not yet been *** To identify SSL-related tiRNAs and their potential role in the development of SSLs and serrated pathway of colorectal cancer(CRC).METHODS Small-RNA sequencing was conducted in paired SSLs and their adjacent normal control(NC)*** expression levels of five SSL-related tiRNAs were validated by q-polymerase chain *** counting kit-8 and wound healing assays were performed to detect cell proliferation and *** target genes and sites of tiRNA-1:33-Pro-TGG-1(5′tiRNA-Pro-TGG)were predicted by TargetScan and miRanda ***-associated and immune-related pathways were analyzed by single-sample gene set enrichment *** analyses were performed to establish the roles of 5′tiRNA-Pro-TGG based on the target *** In total,we found 52 upregulated tsRNAs and 28 downregulated tsRNAs in SSLs compared to *** expression levels of tiRNA-1:33-Gly-CCC-2,tiRNA-1:33-Pro-TGG-1,and tiRNA-1:34-Thr-TGT-4-M25′tiRNAs were higher in SSLs than those in NC,while that of 5′tiRNA-Pro-TGG was associated with the size of *** was demonstrated that 5′tiRNAPro-TGG promoted cell proliferation and migration of RKO cell in ***,heparanase 2(HPSE2)was identified as a potential target gene of 5′*** lower expression was associated with a worse prognosis in ***,lower expression of HPSE2 was observed in SSLs compared to normal controls or conventional adenomas and in BRAF-mutant CRC compared to BRAF-wild *** analyses revealed that its low expression was associated with a low interferonγresponse and also with many metabolic pathways such as riboflavin,retinol,and cy

关键词： Noncoding RNA tRNA halves Sessile serrated lesions Colon cancer Serrated pathway

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Effect of Yang-activating and stasis-eliminating decoction from Traditional Chinese Medicine on intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium

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Journal of Traditional Chinese Medicine 2017年第4期37卷 452-460页

作者： Shi Lijie Shi Lei Liu Leilei Feng Xiuxian Wang Jing Yang Qiang Chai Shiwei Gou Jing Zang Fenglin He Sufei department of spleen and stomach First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China department of Graduate School of Beijing University of Chinese Medicine Beijing 100029 China department of Graduate School of Tianjin University of Traditional Chinese Medicine Tianjin 300000 China department of spleen and stomach Shijiazhuang Traditional Chinese Medicine hospital Shijiazhuang 050000 China department of Pharmacy First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China department of Clinical Laboratory First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China department of Pathology Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China department of Scientific Research Tianjin University of Traditional Chinese Medicine Tianjin 300073 China

OBJECTIVE: To evaluate the effect of decoction prepared with Yang-activating and stasis-eliminating medicinals from Traditional Chinese Medicine(TCM) on the intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium(DSS).METHODS: Totally 55 male Wistar rats(body weight of 170-190 g) were randomly divided into the blank group(n = 10) and the model duplication group(n = 45). The blank group was not intervened, while the other was modeled with 5% dextran sulfate sodium by gavaging in a dosage of4 m L per day to induce ulcerative colitis, a total of7 days. Then, the model rats were divided into model blank group, mesalazine group and TCM group,and each group was consisted of 15 rats. They were given retention enema 10 min with normal saline,mesalazine enema(0.036 g/m L), and Yang-activating and stasis-eliminating decoction [0.54 g/m L of a decoction boiled by Puhuang(Pollen Typhae), Xiebai(Bulbus Allii Macrostemonis) and Wulingzhi(Faeces Trogopteri)] for 10 days respectively. Afterwards,all of the rats were evaluated by disease activity index(DAI), histological changes of distal colon, expression of occludin protein and ultrastructure of intestinal epithelial cells. Furthermore, ratio of lactulose to mannitol(L/M) discharged in urine was ***: Comparing the results between TCM and model control groups, scores of DAI and histological lesions decreased significantly(P = 0.000 0.05).CONCLUSION: The decoction prepared with Yang-activating and stasis-eliminating TCM medicianls can restore intestinal mucosal epithelial cells and tight junctions the model rats with ulcerative colitis; it can redu

关键词： Colitis, ulcerative Epithelial cells Intestinal mucosa Permeability Occludin Dextran sulfate Removing blood stasis Activating Yang Medicine, Chinese Traditional

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Impact of cap-assisted colonoscopy during transendoscopic enteral tubing:A randomized controlled trial

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World Journal of Gastroenterology 2020年第39期26卷 6098-6110页

作者： Quan Wen Kang-Jian Liu Bo-Ta Cui Pan Li Xia Wu Min Zhong Lu Wei Hua Tu Yu Yuan Da Lin Wen-Hung Hsu Deng-Chyang Wu Hong Yin Fa-Ming Zhang Medical Center for Digestive diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina department of spleen and stomach diseases Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061Hubei ProvinceChina department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung 807Taiwan department of Gastroenterology Zigong Fourth People’s HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Colonic transendoscopic enteral tubing(TET)requires double cecal intubation,raising a common concern of how to save cecal intubation time and make the tube *** hypothesized that cap-assisted colonoscopy(CC)might reduce the second cecal intubation time and bring potential benefits during the TET *** To investigate if CC can decrease the second cecal intubation time compared with regular colonoscopy(RC).METHODS This prospective multicenter,randomized controlled trial was performed at four ***≥7 years needing colonic TET were recruited from August 2018 to January *** subjects were randomly assigned to two *** primary outcome was the second cecal intubation *** outcomes included success rate,insertion pain score,single clip fixation time,purpose and retention time of TET tube,length of TET tube inserted into the colon,and all procedurerelated(serious)adverse *** A total of 331 subjects were randomized to the RC(n=165)or CC(n=166)*** median time of the second cecal intubation was significantly shorter for CC than RC(2.2 min vs 2.8 min,P<0.001).In patients with constipation,the median time of second cecal intubation in the CC group(n=50)was shorter than that in the RC group(n=43)(2.6 min vs 3.8 min,P=0.004).However,no difference was observed in the CC(n=42)and RC(n=46)groups of ulcerative colitis patients(2.0 min vs 2.5 min,P=0.152).The insertion pain score during the procedure in CC(n=14)was lower than that in RC(n=19)in unsedated colonoscopy(3.8±1.7 vs 5.4±1.9;P=0.015).Multivariate analysis revealed that only CC(odds ratio[OR]:2.250,95%confidence interval[CI]:1.161-4.360;P=0.016)was an independent factor affecting the second cecal intubation time in difficult *** did not affect the colonic TET tube’s retention time and length of the tube inserted into the ***,multivariate analysis found that only endoscopic clip number(OR:2.201,95%CI:1.541-3.143;P<0.001)was an independe

关键词： Transendoscopic enteral tube Endoscopy Colonoscopy Fecal microbiota transplant Washed microbiota transplant Colon

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Effect of Banxiaxiexin Tang on treatment of functional dyspepsia: a Meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medicine 2014年第2期34卷 140-144页

作者： Yongkang Gan Huayi Liu Liu Yang Kuo Yang School of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine department of spleen and stomach Tianjin Academy of Traditional Chinese Medicine Affiliated Hospitial

OBJECTIVE: To evaluate the efficacy of Banxiaxiexin Tang compared with Western Medicine in the treatment of functional dyspepsia(FD) through ***: Literature was searched in the following databases: MEDLINE, Excerpta Medica Database, Chinese Medical Current Contents, China Science and Technology Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. Randomized controlled trials evaluating the efficacy of Banxiaxiexin Tang for the treatment of FD were selected according to certain standards including clear general situation of patients, specific diagnostic criteria, definite clinical outcomes, etc. Articles were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analysis was conducted with RevMan 5.0.23 ***: Ten articles with a total of 972 patients were included. The comparison of efficacy between Banxiaxiexin Tang and Western Medicine showed a combined effect size [OR=2.75, 95% CI(1.86-4.07)]andcombinedeffectofvalueofZ=5.07(P<0.000 01),suggesting a significant difference between the ***: Banxiaxiexin Tang was more effective thanWestern Medicine in treating FD.

关键词： Dyspepsia Randomized controlled trials Meta-analysis Banxiaxiexin Tang

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Efficacy and effect on related brain-gut peptides of acupoint sticking therapy for functional dyspepsia

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Journal of Acupuncture and Tuina Science 2021年第5期19卷 384-388页

作者： Kong Wei-guang He Tian-feng Kong Xie-he department of spleen and stomach diseases Inner Mongolia Hospital of Traditional Chinese MedicineHuhhot 010020China department of Acupuncture Jiading Hospital of Traditional Chinese MedicineShanghaiShanghai 201899China 不详

Objective:To observe the efficacy of acupoint sticking with Jianpi Tongjing Zhitong ointmerrt in the treatment of functional dyspepsia due to liver-qi stagnation and spleen deficiency and its effect on serum 5-hydroxytryptamine(5-HT)and ghrelin con ***:One hun dred patients with functi onal dyspepsia due to liver-qi stag nation and spleen deficiency were divided into a treatment group and a control group by the random number table method,with 50 cases in each *** treatment group received acupoint sticking with Jianpi Tongjing Zhitong ointment and the control group was treated with mosapride citrate *** were treated for 4 weeks as a *** therapeutic efficacy was compared after one-course treatment and the differences in gastric emptying rate,and serum 5-HT and ghrelin contents between groups were compared before and after ***:The total effective rate was 79.6%in the control group and 89.4%in the treatment group,showing significantly differe nt between groups(Pspleen deficiency and is able to in fluence the se

关键词： Acupoi nt Sticking Therapy Emplastrum Therapy Dyspepsia Liver-qi Stag nation日nd spleen Deficie ncy Brain-gut Peptide 5-hydroxytryptamine Ghrelin

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Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1149-1154页

作者： Li Han Kun Tang Xiao-Li Fang Jing-Xi Xu Xi-Yun Mao Ming Li department of Anorectal Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui HospitalHefei 230001Anhui ProvinceChina Anorectal Center The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230001Anhui ProvinceChina department of spleen and stomach diseases Department of GastroenterologyAffiliated Wuhu Hospital of Traditional Chinese Medicine of Anhui College of Traditional Chinese MedicineWuhu 241000Anhui ProvinceChina

BACKGROUND Ulcer colitis(UC)is a chronic,nonspecific,and noninfectious inflammatory bowel ***,Toll-like receptors(TLRs)have been found to be closely associated with clinical inflammatory *** complete remission in patients with intermittent periods of activity followed by dormancy is ***,no study has explored the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** This prospective clinical study included patients who met the exclusion criteria in 2020 and *** patients with UC were divided into two groups(control and experimental).The peripheral blood of the experimental and control groups were collected under aseptic *** expression of TLR4 protein,NF-κB,IL-6,and IL-17 was detected in the peripheral blood of patients in the experimental group and control group before and 1 month after taking the *** co rrelation analysis was used to analyze the relationship between the expression level of TLR4 protein and the expression levels of downstream signal NF-κB and inflammatory factors IL-6 and IL-17,and P<0.05 was considered statistically *** There were no significant differences in the patient characteristics between the control and experimental *** results showed that the expression levels of TLR4 and NF-κB in the experimental group were significantly lower than those in the control group(P<0.05).The levels of IL-6 and IL-17 in the experimental group were significantly lower than those in the control group(P<0.05).The TLR4 protein expression in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-

关键词： Ulcerative colitis TLR4 NF-κB signaling pathway Kuicolong-yu enema

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