Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway
作者机构：Department of AnorectalShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui HospitalHefei 230001Anhui ProvinceChina Anorectal CenterThe First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230001Anhui ProvinceChina Department of Spleen and Stomach DiseasesDepartment of GastroenterologyAffiliated Wuhu Hospital of Traditional Chinese Medicine of Anhui College of Traditional Chinese MedicineWuhu 241000Anhui ProvinceChina
出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)
年 卷 期：2024年第16卷第4期
页 面：1149-1154页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Ulcerative colitis TLR4 NF-κB signaling pathway Kuicolong-yu enema
摘 要：BACKGROUND Ulcer colitis(UC)is a chronic,nonspecific,and noninfectious inflammatory bowel ***,Toll-like receptors(TLRs)have been found to be closely associated with clinical inflammatory *** complete remission in patients with intermittent periods of activity followed by dormancy is ***,no study has explored the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** This prospective clinical study included patients who met the exclusion criteria in 2020 and *** patients with UC were divided into two groups(control and experimental).The peripheral blood of the experimental and control groups were collected under aseptic *** expression of TLR4 protein,NF-κB,IL-6,and IL-17 was detected in the peripheral blood of patients in the experimental group and control group before and 1 month after taking the *** co rrelation analysis was used to analyze the relationship between the expression level of TLR4 protein and the expression levels of downstream signal NF-κB and inflammatory factors IL-6 and IL-17,and P0.05 was considered statistically *** There were no significant differences in the patient characteristics between the control and experimental *** results showed that the expression levels of TLR4 and NF-κB in the experimental group were significantly lower than those in the control group(P0.05).The levels of IL-6 and IL-17 in the experimental group were significantly lower than those in the control group(P0.05).The TLR4 protein expression in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-
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