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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA department of public health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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Assessing healthcare workers’knowledge and confidence in the diagnosis,management and prevention of Monkeypox

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World Journal of Clinical Cases 2025年第1期13卷 38-47页

作者： Epipode Ntawuyamara Thierry Ingabire Innocent Yandemye Polycarpe Ndayikeza Bina Bhandari Yan-Hua Liang department of Dermatology Cosmetology and VenereologyShenzhen Hospital of Southern Medical UniversityShenzhen 518101Guangdong ProvinceChina department of Dermatology and Venereology Kamenge Teaching HospitalUniversity of BurundiBujumbura 1020Burundi department of infectious diseases Kamenge Teaching HospitalUniversity of BurundiBujumbura 1020Burundi General Directorate of healthcare Supply Modern and Traditional MedicineNutrition and RegistrationMinistry of Public Health and Fight Against HIV/AIDSBujumbura 1055Burundi department of Epidemiology National Institute of Public HealthBujumbura 350Burundi General Directorate of Planification Ministry of Public Health and Fight Against HIV/AIDSBujumbura 1055Burundi

BACKGROUND Monkeypox(Mpox),is a disease of global public health concern,as it does not affect only countries in western and central *** To assess Burundi healthcare workers(HCWs)s’level of knowledge and confidence in the diagnosis and management of *** We conducted a cross-sectional study via an online survey designed mainly from the World health Organization course distributed among Burundi HCWs from June-July *** questionnaire comprises 8 socioprofessional-related questions,22 questions about Mpox disease knowledge,and 3 questions to assess confidence in Mpox diagnosis and *** data were analyzed via SPSS software version 25.0.A P value<0.05 was considered to indicate statistical *** The study sample comprised 471 HCWs who were mainly medical doctors(63.9%)and nurses(30.1%).None of the 22 questions concerning Mpox knowledge had at least 50%correct responses.A very low number of HCWs(17.4%)knew that Mpox has a *** confidence level to diagnose(21.20%),treat(18.00%)or prevent(23.30%)Mpox was low among *** confidence level in the diagnosis of Mpox was associated with the HCWs’age(P value=0.009),sex(P value<0.001),work experience(P value=0.002),and residence(P value<0.001).The confidence level to treat Mpox was significantly associated with the HCWs’age(P value=0.050),sex(P value<0.001),education(P value=0.033)and occupation(P value=0.005).The confidence level to prevent Mpox was associated with the HCWs’education(P value<0.001),work experience(P value=0.002),residence(P value<0.001)and type of work institution(P value=0.003).CONCLUSION This study revealed that HCWs have the lowest level of knowledge regarding Mpox and a lack of confidence in the ability to diagnose,treat or prevent *** is an urgent need to organize continuing medical education programs on Mpox epidemiology and preparedness for Burundi *** encourage future researchers to assess potential hesitancy toward Mpox vaccination and its asso

关键词： Monkeypox public health emergency of international concern healthcare workers Epidemic Preparedness Knowledge Confidence

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping Yu department of Infection disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

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The collaboration between infectious disease modeling and public health decision-making based on the COVID-19

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Journal of Safety Science and Resilience 2021年第2期2卷 69-76页

作者： Yan Niu Zhuoyang Li Ling Meng Shengnan Wang Zeyu Zhao Tie Song Jianhua Lu Tianmu Chen Qun Li Xuan Zou public health Emergency Center Chinese Center for Disease Control and PreventionBeijing102206China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamenFujian361005China School of public health Weifang Medical UniversityWeifang Shandong261000China Guangdong Provincial Center for disease Control and Prevention GuangzhouGuangdong511430China Shenzhen Center for disease Control and Prevention ShenzhenGuangdong518055China

public health decision-making may have great uncertainty especially in dealing with emerging infectious diseases,so it is necessary to establish a collaborative mechanism among modelers,epidemiologists,and public health decision-makers to reduce the uncertainty as much as *** searched the relevant studies on transmission dynamics modeling of infectious diseases,SARS,MERS,and COVID-19 as of March 1,2021 based on *** compared the key health decision-making time points of SARS,MERS,and COVID-19 prevention and control,and the publication time points of modeling research,to reveal the collaboration between infectious disease modeling and public health decision-making in the context of the COVID-19 *** with infectious disease and mathematical model as keywords,there were 166,81 and 1289 studies on the modeling of infectious disease transmission dynamics of SARS,MERS,and COVID-19 were retrieved *** on the modeling application framework of public health practice proposed in the current study,the collaboration among modelers,epidemiologists and public health decision-makers should be strengthened in the future.

关键词： COVID-19 infectious disease modeling Decision-making

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Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes

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World Journal of Clinical Cases 2025年第5期13卷 22-29页

作者： Hong Shi Chun Liu Hong-Yan Luo department of Infrastructure Operation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina department of public health Minzu Street Community Health Service CenterWuhan 430000Hubei ProvinceChina Caotang Community health Service Center Chengdu 610031Sichuan ProvinceChina

BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease *** To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with *** One hundred patients with T2DM were selected as the research *** patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table *** conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing *** rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two *** The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both *** cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than

关键词： Community public health care Type 2 diabetes Blood sugar control Self-management ability Cognition level

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Review of clinical characteristics,immune responses and regulatory mechanisms of hepatitis E-associated liver failure

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World Journal of Clinical Cases 2022年第19期10卷 6341-6348页

作者： Chong Chen Shu-Ye Zhang Liang Chen department of infectious disease Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China department of Hepatology Shanghai Public Health Clinical CenterShanghai 201508China

Hepatitis E virus(HEV)is the most common cause of acute liver failure(LF)and one of the most common factors causing acute injury in acute-on-chronic LF(ACLF).When HEV-related LF occurs,a series of changes take place in both the intrahepatic environment and extrahepatic *** changed types and distribution of immune cells(infiltrating macrophages and increased lymphocytes)in liver tissue,as well the increased proinflammatory cytokines and chemokines in the blood,indicate that the occurrence and progression of HEVrelated LF are closely related to immune *** clinical features and immune reaction in the body during HEV-related acute LF(ALF)and ACLF are *** review highlights recent progress in elucidating the clinical manifestations of HEV-associated ALF and ACLF and discusses the corresponding systemic immune changes and possible regulatory mechanisms.

关键词： Hepatitis E virus Acute liver failure Acute-on-chronic liver failure Immune cells Cytokines Mechanism

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng Yan Han Ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang Xiao-Pan Li department of health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of public health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of disease Risk factors Disability-adjusted life years

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Risk factors from HBV infection among blood donors:A systematic review

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 344-349页

作者： Giuseppe La Torre Rosella Saulle department of public health and infectious diseases "Sapienza" University of Rome

Objective:To perform a systematic review of the scientific literature to identify risk factors associated with hepatitis B viruses(HBV) infection among blood ***:The literature search was carried out on Pub Med and Scopus databases using the keywords "risk factors" "HBV infection" and "blood donors".No date or language restrictions were applied to the *** literature review was completed in *** selection process and the reporting of the review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** Newcastle Ottawa scale was using to evaluate the quality of each single primary ***:Out of 172 records resulted in the search,5 papers were included in the final analysis because they are within acceptance *** of the selected studies were cross-sectional and three of them were case-control *** association resulted with some demographic and behavioral risk factors,such as marital status,dental treatment/procedure history,no stable relationship or multiple partners and family history of HBV ***:The systematic review performed encourages to conduct further research among blood donors in order to fully understand risk factors among donors in more extensive thus to provide valuable information about surveillance.

关键词： Risk factors HBV Infection Blood donors Systematic review

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Estimating Changes in Contact Patterns in China Over the First Year of the COVID-19 Pandemic:Implications for SARS-CoV-2 Spread—Four Cities,China,2020

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China CDC weekly 2023年第5期5卷 113-119,I0012-I0017页

作者： Yuxia Liang Cheng Peng Qian You Maria Litvinova Marco Ajelli Juanjuan Zhang Hongjie Yu School of public health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai MunicipalityChina Laboratory for Computational Epidemiology and public health Department of Epidemiology and BiostatisticsIndiana University School of Public HealthBloomingtonINUSA Shanghai Institute of infectious disease and Biosecurity Fudan UniversityShanghai MunicipalityChina

Introduction:Previous studies have demonstrated significant changes in social contacts during the firstwave coronavirus disease 2019(COVID-19)in Chinese *** purpose of this study was to quantify the time-varying contact patterns by age in Chinese mainland in 2020 and evaluate their impact on the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods:Diary-based contact surveys were performed for four periods:baseline(prior to 2020),outbreak(February 2020),post-lockdown(March–May 2020),and post-epidemic(September–November 2020).We built a Susceptible-Infected-Recovered(SIR)model to evaluate the effect of reducing contacts on ***:During the post-epidemic period,daily contacts resumed to 26.7%,14.8%,46.8%,and 44.2%of the pre-COVID levels in Wuhan,Shanghai,Shenzhen,and Changsha,*** suggests a moderate risk of resurgence in Changsha,Shenzhen,and Wuhan,and a low risk in *** closure alone was not enough to interrupt transmission of SARS-CoV-2 Omicron BA.5,but with the addition of a 75%reduction of contacts at the workplace,it could lead to a 16.8%reduction of the attack *** control an outbreak,concerted strategies that target schools,workplaces,and community contacts are ***:Monitoring contact patterns by age is key to quantifying the risk of COVID-19 outbreaks and evaluating the impact of intervention strategies.

关键词： mainland resume contacts

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Risk Factors Associated with the Spatiotemporal Spread of the SARS-CoV-2 Omicron BA.2 Variant—Shanghai Municipality,China,2022

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China CDC weekly 2023年第5期5卷 97-102,I0001-I0005页

作者： Wen Zheng Xiaowei Deng Cheng Peng Xuemei Yan Nan Zheng Zhiyuan Chen Juan Yang Marco Ajelli Juanjuan Zhang Hongjie Yu School of public health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai MunicipalityChina Laboratory for Computational Epidemiology and public health Department of Epidemiology and BiostatisticsIndiana University School of Public HealthBloomingtonINUSA Shanghai Institute of infectious disease and Biosecurity Fudan UniversityShanghai MunicipalityChina

Summary What is already known about this topic?Previous studies have explored the spatial transmission patterns of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and have assessed the associated risk ***,none of these studies have quantitatively described the spatiotemporal transmission patterns and risk factors for Omicron BA.2 at the micro(within-city)scale.

关键词： acute assessed respiratory

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