Review of clinical characteristics,immune responses and regulatory mechanisms of hepatitis E-associated liver failure

作     者：Chong Chen Shu-Ye Zhang Liang Chen 

作者机构：Department of Infectious DiseaseShanghai Public Health Clinical CenterFudan UniversityShanghai 201508China Department of HepatologyShanghai Public Health Clinical CenterShanghai 201508China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第19期

页      面：6341-6348页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Shanghai Shenkang Hospital Development Center,No.SHDC12020109 Shanghai Association for Science and Technology,No.21S11905600 Plan of the Research Project Funded by Shanghai Public Health Clinical Centre,No.KY-GW-2022-22 

主　　题：Hepatitis E virus Acute liver failure Acute-on-chronic liver failure Immune cells Cytokines Mechanism 

摘      要：Hepatitis E virus(HEV)is the most common cause of acute liver failure(LF)and one of the most common factors causing acute injury in acute-on-chronic LF(ACLF).When HEV-related LF occurs,a series of changes take place in both the intrahepatic environment and extrahepatic *** changed types and distribution of immune cells(infiltrating macrophages and increased lymphocytes)in liver tissue,as well the increased proinflammatory cytokines and chemokines in the blood,indicate that the occurrence and progression of HEVrelated LF are closely related to immune *** clinical features and immune reaction in the body during HEV-related acute LF(ALF)and ACLF are *** review highlights recent progress in elucidating the clinical manifestations of HEV-associated ALF and ACLF and discusses the corresponding systemic immune changes and possible regulatory mechanisms.