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Research 2024年第1期2023卷 721-733页

作者： Miao Liu Haiqing Zhang Zhichao Wang Tingting Mo Xuefeng Lai Yaling He Minghui Jiang Meian He Weijia Kong Tangchun Wu Xiaomin Zhang department of Occupational and Environmental health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was *** present study included 15,827 participants from the Dongfeng–Tongji cohort *** risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing *** conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with *** showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 *** 10:00 *** to those with bedtime>10:00 *** 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions:progress in efficacy and geographic equality

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National science Review 2024年第2期11卷 103-113页

作者： Tao Xue Ruohan Wang Meng Wang Yanying Wang Dan Tong Xia Meng Conghong Huang Siqi Ai Fangzhou Li Jingyuan Cao Mingkun Tong Xueqiu Ni Hengyi Liu Jianyu Deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu Institute of Reproductive and Child health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public Health Peking University Health Science Centre State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health Peking University Advanced Institute of Information Technology Peking University department of Epidemiology and Environmental health School of Public Health and Health ProfessionsUniversity at Buffalo State Key Joint Laboratory of Environment Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University department of Earth System science Tsinghua University School of public health Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University College of Land Management Nanjing Agricultural University National&Local Joint Engineering Research Center for Rural Land Resources Use and Consolidation Clean Air Asia

Clean air actions （CAAs） in China have been linked to considerable benefits in public ***,whether the beneficial effects of CAAs are equally distributed geographically is *** high-resolution maps of the distributions of major air pollutants (fine particulate matter[PM2.5]and ozone[O3]) and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to PM2.5and O3from 2013 to *** used a method established by the Global Burden of Diseases *** analyzing the changes in loss of life expectancy（LLE） attributable to PM2.5and O3,we calculated the gain of life expectancy （GLE） to quantify the health benefits of the air-quality ***,we assessed the geographic inequality embedded in the GLE using the Gini index （GI）.Based on risk assessments of PM2.5and O3,during the first stage of CAAs（2013 to 2017）,the mean GLE was 1.87 *** of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed （GI 0.44）.During the second stage of CAAs（2017 to 2020）,the mean GLE increased to 3.94 months and geographic inequality decreased （GI 0.18）.According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health *** enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of PM2.5and *** findings will contribute to optimizing future CAAs.

关键词： clean air action public health inequality fine particulate matter ozone

Applying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated health in Old Age-China and the US,2020-2021

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China CDC weekly 2024年第11期6卷 213-218,I0008-I0013页

作者： Shutong Huo Derek Feng Thomas M.Gill Xi Chen department of health Society&BehaviorPublic HealthUniversity of CaliforniaIrvineCAUSA department of Statistics and Data science Yale UniversityNew HavenCTUS department of Internal Medicine Yale School of MedicineNew HavenCTUS department of health Policy and Management Yale School of Public HealthNew HavenCTUS department of Economics Yale UniversityNew HavenCTUS.

Introduction:Childhood circumstances impact senior health,prompting the introduction of machine learning methods to assess their individual and collective contributions to senior ***:Using health and retirement study(HRS)and China health and Retirement Longitudinal Study(CHARLS),we analyzed 2,434 American and 5,612 Chinese participants aged 60 and *** inference trees and forests were employed to estimate the influence of childhood circumstances on self-rated health(SRH).Results:The conventional method estimated higher inequality of opportunity(IOP)values in both China(0.039,accounting for 22.67%of the total Gini coefficient 0.172)and the US(0.067,accounting for 35.08%of the total Gini coefficient 0.191).In contrast,the conditional inference tree yielded lower estimates(China:0.022,accounting for 12.79%of 0.172;US:0.044,accounting for 23.04%of 0.191),as did the forest(China:0.035,accounting for 20.35%of 0.172;US:0.054,accounting for 28.27%of 0.191).Childhood health,financial status,and regional differences were key determinants of senior *** conditional inference forest consistently outperformed others in predictive accuracy,as demonstrated by lower out-of-sample mean squared error(MSE).Discussion:The findings emphasize the need for early-life interventions to promote health equity in aging *** learning showcases the potential in identifying contributing factors.

关键词： collective inequality estimates

Genetic Variations and Nonalcoholic Fatty Liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence

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Biomedical and Environmental sciences 2024年第7期37卷 762-773页

作者： Yamei Li Xiang Xiao Jie Wang Yixu Liu Xiongfeng Pan Haibin Yu Jiayou Luo Miyang Luo department of Epidemiology and health Statistics School of Public HealthUniversity of South ChinaHengyang 421001HunanChina department of Maternal and Child health Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina Supervision and Inspection department of Shanghai healthcare Security Bureau Shanghai 200003China department of Epidemiology and health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina

Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of science,PubMed,and Embase between January 1980 and September 2022 was systematically ***-analyses of the genetic variants were conducted using at least five data *** epidemiologic credibility of the significant associations was graded using the Venice *** Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing *** identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the *** meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

关键词： Nonalcoholic fatty liver disease Genetic association study Genetic variant Systematic review Meta-analysis

Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

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Journal of Rare Earths 2024年第3期42卷 555-561,I0005页

作者： Muteb H.Alshammari Ahmed Onayzan Alshammari Mohamed Tharwat Elabbasy Rafat Zreiq Faris Mohammed Albati M.A.El-Morsy A.A.Menazea department of health Informatics College of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia department of Surgery College of MedicineUniversity of Ha'ilHa'ilSaudi Arabia department of public health College of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied science Research Center Applied Science Private UniversityAmman541350Jordan College of Shariah and Law Ha'il UniversityHa'il2440Saudi Arabia College of science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics department Faculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy department Physics Research InstituteNational Research CentreDokki12622GizaEgypt

Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEM). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关键词： Wound healing Wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths

Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblast differentiation

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science China(Life sciences) 2024年第5期67卷 970-985页

作者： Huaqi Guo Luo Fei Hengyi Yu Yan Li Yan Feng Shaowei Wu Yan Wang The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China School of public health Shanghai Jiao Tong University School of MedicineShanghai 200020China department of Occupational and Environmental health sciences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphysema,myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution,especially fine particulate matter(PM_(2.5)),leading to chronic obstructive pulmonary disease(COPD).Specifically,bronchial epithelium-fibroblast communication participates in airway remodeling,which results in *** increasing number of studies are now being conducted on the role of exosome-mediated cell-cell communication in disease ***,we investigated whether exosomes generated from bronchial epithelial cells could deliver information to normal stromal fibroblasts and provoke cellular responses,resulting in airway obstruction in *** studied the mechanism of exosome-mediated intercellular communication between human bronchial epithelial(HBE) cells and primary lung fibroblasts(pLFs).We found that PM_(2.5)-induced HBE-derived exosomes promoted myofibroblast differentiation in ***,the exosomal lncRNA expression profiles derived from PM_(2.5)-treated HBE cells and nontreated HBE cells were investigated using an Agilent Human LncRNA *** coculture assays and direct exosome treatment,we found that HBE cell-derived exosomal HOTAIRM1 facilitated the myofibroblast differentiation of ***,we discovered that exosomal HOTAIRM1 enhanced p LF proliferation to secrete excessive collagen secretion,leading to airway obstruction by stimulating the TGF-β/SMAD3 signaling ***,PM_(2.5)reduced FEV1/FVC and FEV1 and increased the level of serum exosomal HOTAIRM1 in healthy people;moreover,serum exosomal HOTAIRM1 was associated with PM_(2.5)-related reductions in FEV1/FVC and *** findings show that PM_(2.5)triggers alterations in exosome components and clarify that one of the paracrine mediators of myofibroblast differentiation is bronchial epithelial cell-derived HOTAIRM1,which has the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exosomal lncRNAs HOTAIRM1 chronic obstructive pulmonary disease

Association of Thallium Exposure with Decreased Renal Function among Chinese Adults—China,2017-2018

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China CDC weekly 2024年第34期6卷 867-871,I0007-I0010页

作者： Zheng Zhang Miao Zhang Yingli Qu Feng Zhao Saisai Ji Zheng Li Bing Wu Chunxian Lyu Haocan Song Qi Sun Yawei Li Xu Zhang Xulin Zheng Yidan Qiu Zihan Lu Hui Fu Lanjing Xu Wenli Zhang Yufei Luo Fangyu Li Jiayi Cai Yuanduo Zhu Ying Zhu Zhaojin Cao Yuebin Lyu Xiaoming Shi China CDC Key Laboratory of Environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Center for Global health School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina department of Big Data in health science School of Public HealthZhejiang UniversityHangzhou CityZhejiang ProvinceChina department of Occupational health and Environment health School of Public HealthAnhui Medical UniversityHefei CityAnhui ProvinceChina School of public health China Medical UniversityShenyang CityLiaoning ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Thallium(Tl)is significantly more toxic than heavy metals such as lead,cadmium,and ***,previous studies examining the relationship between Tl exposure and the risk of chr... 详细信息

关键词： Renal kidney mercury

Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years:evidence from a birth cohort study in China

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World Journal of Pediatrics 2024年第7期20卷 701-711页

作者： Chao Xiong Kai Chen Lu-Li Xu Yi-Ming Zhang Hua Liu Meng-Lan Guo Zhi-Guo Xia Yu-Ji Wang Xiao-Feng Mu Xiao-Xuan Fan Jing-Quan Chen Yu-Ru Liu Yuan-Yuan Li Wei Xia You-Jie Wang Ai-Fen Zhou Wuhan Children’s Hospital(Wuhan Maternal and Child healthcare Hospital) Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430016China Key Laboratory of Environment and health Ministry of Education and Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Maternal and Child health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early *** findings warrant an investigation of the relationship between prenatal bisphenol exposure and the dynamic growth of *** study aimed to evaluate the relationship of maternal bisphenol concentration in urine with the body mass index(BMI)growth trajectory of children aged up to two years and to identify the critical exposure *** A total of 826 mother–offspring pairs were recruited from Wuhan Children’s Hospital between November 2013 and March *** urine samples collected during the first,second,and third trimesters were analyzed for bisphenol A(BPA),bisphenol S,and bisphenol F(BPF)*** of length and weight were taken at 0,1,3,6,8,12,18,and 24 ***'s BMI was standardized using the World health Organization reference,and group-based trajectory modeling was used to identify BMI growth *** associations between prenatal bisphenol exposure and BMI growth trajectory patterns were assessed using multinomial logistic regression *** The BMI growth trajectories of the 826 children were categorized into four patterns:low-stable(n=134,16.2%),low-increasing(n=142,17.2%),moderate-stable(n=350,42.4%),and moderate-increasing(n=200,24.2%).After adjusting for potential confounders,we observed that prenatal exposure to BPA during the second trimester[odds ratio(OR)=2.20,95%confidence interval(CI)=1.09–4.43]and BPF during the third trimester(OR=3.28,95%CI=1.55–6.95)at the highest quartile concentration were associated with an increased likelihood of the low-increasing BMI ***,in the subgroup analysis by infant sex,the positive association between the highest quartile of prenatal average urinary BPF concentration during the whole pregnancy and the low-increasing BMI trajectory was found only in girls(OR=2.82,95%CI=1.04–7.68).Conclus

关键词： Birth cohort study Bisphenol A Bisphenol S Bisphenol F Body mass index trajectory Prenatal exposure

Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control

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Journal of Sport and health science 2024年第4期13卷 559-568,F0003页

作者： Kyung-Min Kim Joo-Sung Kim Alan R.Needle department of Sport science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea department of health and Human Performance Texas State UniversitySan MarcosTX 78666USA department of public health&Exercise science Appalachian State UniversityBooneNC 28608USA department of Rehabilitation science Appalachian State UniversityBooneNC 28608USA

Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural *** muscle inhibition(AMI)has been observed in this population;however,relationships with injury-related impairments are unclear,potentially due to the resting,prone position in which AMI is typically *** AMI during bipedal stance may provide a better understanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injury:10 males,21.4±2.7 years;19 healthy controls:10 males,21.9±2.2 years;mean±SD)using the Hoffmann reflex(H-reflex)during bipedal *** stimulation was administered to identify the _(max)imal H-reflex(H_(max))and _(max)imal motor response(M_(max))from the soleus,fibularis longus,and tibialis anterior *** primary outcome measure was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postural control during bipedal stance,and self-reported ***:No significant group-by-limb interactions were observed for any ***,a significant group main effect was observed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower H_(max)/M_(max) ratios following ALAS(0.38±0.20)compared to healthy controls(0.53±0.16).Furthermore,lower H_(max)/M_(max) ratios in the soleus significantly correlated with acute symptoms and self-reported function but not with postural ***:This study supports previous evidence of AMI in patients with ALAS,providing insight into neurophysiologic impacts of musculoskeletal *** results suggest that assessing AMI in a standing position following acute injury may provide valuable insight into how AMI develops and guide potential therapeutic options to curb and offset the formation of joint instability.

关键词： Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes

Comparison of toxicity between lanthanum oxide nanoparticles and lanthanum chloride

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Journal of Rare Earths 2024年第2期42卷 424-430,I0007页

作者： Kun Huang Songchang Lai Miao Guo Xingwu Zhu Jiashuangwei Yuan Zhehao Liu Gonghua Hu Yanfang Gao School of public health and health Management Gannan Medical UniversityGanzhou341000China

Due to the wide application of rare earth elements,lanthanum(La) is gradually accumulated in our living *** can enter the body through a variety of routes,which has a series of effects on various *** a consequence,the safety of lanthanum deserves our *** study aims to compare the toxicity of lanthanum oxide nanoparticles(La_(2)O_(3) NPs) and lanthanum chloride(LaCl_(3)) and enrich the toxicity evaluation of ***,a 30 d intragastal experiment was conducted.C57BL/6j mice were given by La_(2)O_(3) NPs solution and LaCl_(3) solution respectively at doses of 0,30,60 and120 mg/kg BW(lanthanum content).The results show that,compared with the control group,both La_(2)O_(3)NPs and LaCl_(3) can reduce the body weight of female mice in the high-dose group,but for male mice,the high-dose La_(2)O_(3) NPs solution can increase the body weight,while LaCl_(3) has the opposite *** coefficients of liver,kidney,heart,lung,uterine and ovaries increase first and then decrease with the exposure dose,but testes and epididymides coefficient keep increasing with the exposure of LaCl_(3) and La_(2)O_(3) ***_(2)O_(3) NPs and LaCl_(3) can reduce the concentration of triglycerides(TG) and increase the level of low density lipoprotein(LDL),but the effect of La_(2)O_(3) NPs is more ***_(2)O_(3) NPs and LaCl_(3) can reduce the concentration of malondialdehyde(MDA),increase the total antioxidant capacity(T-AOC)and enhance the activity of catalase(CAT),but LaCl_(3) has more obvious protective effects on oxidative ***_(2)O_(3) NPs and LaCl_(3) have potential risks to liver,and the toxicity of La_(2)O_(3) NPs might be higher than that of LaCl_(3).

关键词： Rare earth elements Lanthanum oxide nanoparticles Lanthanum chloride Lipid metabolism Oxidative stress