Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study
作者机构：Department of Occupational and Environmental HealthMinistry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of OtorhinolaryngologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and BiostatisticsSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina
出 版 物：《Research》 (研究（英文）)
年 卷 期：2024年第2023卷第1期
页 面：721-733页
核心收录：
学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学]
基 金：the Key Research and Development Program of Hubei Province(2022BCA046) the National Natural Scientific Foundation of China(81973128)
摘 要：Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was *** present study included 15,827 participants from the Dongfeng–Tongji cohort *** risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing *** conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with *** showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 *** 10:00 *** to those with bedtime10:00 *** 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.
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