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Vagus nerve stimulation in cerebral stroke:biological mechanisms,therapeutic modalities,clinical applications,and future directions

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Neural Regeneration Research 2024年第8期19卷 1707-1717页

作者： Li Du Xuan He Xiaoxing Xiong Xu Zhang Zhihong Jian Zhenxing Yang department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Stroke is a major disorder of the central nervous system that poses a serious threat to human life and quality of *** stro ke victims are left with long-term neurological dysfunction,which adversely affects the well-being of the individual and the broader socioeconomic ***,poststroke brain dysfunction is a major and difficult area of *** nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autis m,refractory depression,epilepsy,and Alzheimer’s *** is expected to be a novel therapeutic technique for the treatment of stroke owing to its association with multiple mechanisms such as alte ring neurotransmitters and the plasticity of central neuro *** animal models of acute ischemic stroke,vagus nerve stimulation has been shown to reduce infarct size,reduce post-stroke neurological damage,and improve learning and memory capacity in rats with stroke by reducing the inflammatory response,regulating bloodbrain barrier permeability,and promoting angiogenesis and *** present,vagus nerve stimulation includes both invasive and non-invasive vagus nerve *** studies have found that invasive vagus nerve stimulation combined with rehabilitation therapy is effective in im proving upper limb motor and cognitive abilities in stroke *** clinical studies have shown that non-invasive vagus nerve stimulation,including ear/ce rvical vagus nerve stimulation,can stimulate vagal projections to the central nervous system similarly to invasive vagus nerve stimulation and can have the same *** this paper,we first describe the multiple effects of vagus nerve stimulation in stroke,and then discuss in depth its neuroprotective mechanisms in ischemic *** go on to outline the res ults of the current major clinical applications of invasive and non-invasive vagus nerve ***,we provide a more comprehensive evaluation of the advantages and disadvantages of di

关键词： cerebral stroke neuroplasticity non-invasive vagus nerve stimulation rehabilitation vagus nerve stimulation

The action mechanism by which C1q/tumor necrosis factor-related protein-6 alleviates cerebral ischemia/reperfusion injury in diabetic mice

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Neural Regeneration Research 2024年第9期19卷 2019-2026页

作者： Bo Zhao Mei Li Bingyu Li Yanan Li Qianni Shen Jiabao Hou Yang Wu Lijuan Gu Wenwei Gao department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Central Laboratory Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Studies have shown that C1q/tumor necrosis factor-related protein-6 (CTRP6) can alleviate renal ischemia/reperfusion injury in mice. However, its role in the brain remains poorly understood. To investigate the role of CTRP6 in cerebral ischemia/reperfusion injury associated with diabetes mellitus, a diabetes mellitus mouse model of cerebral ischemia/reperfusion injury was established by occlusion of the middle cerebral artery. To overexpress CTRP6 in the brain, an adeno-associated virus carrying CTRP6 was injected into the lateral ventricle. The result was that oxygen injury and inflammation in brain tissue were clearly attenuated, and the number of neurons was greatly reduced. In vitro experiments showed that CTRP6 knockout exacerbated oxidative damage, inflammatory reaction, and apoptosis in cerebral cortical neurons in high glucose hypoxia-simulated diabetic cerebral ischemia/reperfusion injury. CTRP6 overexpression enhanced the sirtuin-1 signaling pathway in diabetic brains after ischemia/reperfusion injury. To investigate the mechanism underlying these effects, we examined mice with depletion of brain tissue-specific sirtuin-1. CTRP6-like protection was achieved by activating the sirtuin-1 signaling pathway. Taken together, these results indicate that CTRP6 likely attenuates cerebral ischemia/reperfusion injury through activation of the sirtuin-1 signaling pathway.

关键词： brain C1q/tumor necrosis factor-related protein-6 cerebral apoptosis diabetes inflammation ischemia/reperfusion injury neuron neuroprotection oxidative damage Sirt1

Ferroptosis:a potential therapeutic target for stroke

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Neural Regeneration Research 2024年第5期19卷 988-997页

作者： Chengli Liu Guijun Wang Wenrui Han Qi Tian Mingchang Li department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Ferroptosis is a form of regulated cell death characterized by massive iron accumulation and iron-dependent lipid peroxidation,differing from apoptosis,necroptosis,and autophagy in several *** is regarded as a critical mechanism of a series of pathophysiological reactions after stroke because of iron overload caused by hemoglobin degradation and iron metabolism *** this review,we discuss ferroptosis-related metabolisms,important molecules directly or indirectly targeting iron metabolism and lipid peroxidation,and transcriptional regulation of ferroptosis,revealing the role of ferroptosis in the progression of *** present updated progress in the intervention of ferroptosis as therapeutic strategies for stroke in vivo and in vitro and summarize the effects of ferroptosis inhibitors on *** review facilitates further understanding of ferroptosis pathogenesis in stroke,proposes new targets for the treatment of stroke,and suggests that more efforts should be made to investigate the mechanism of ferroptosis in stroke.

关键词： cell death ferroptosis oxidative stress stroke treatment

Metabolic and proteostatic differences in quiescent and active neural stem cells

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Neural Regeneration Research 2024年第1期19卷 43-48页

作者： Jiacheng Yu Gang Chen Hua Zhu Yi Zhong Zhenxing Yang Zhihong Jian Xiaoxing Xiong department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Adult neural stem cells are neurogenesis progenitor cells that play an important role in ***,neural regeneration may be a promising target for treatment of many neurological *** regenerative capacity of adult neural stem cells can be chara cterized by two states:quiescent and *** adult neural stem cells are more stable and guarantee the quantity and quality of the adult neural stem cell *** adult neural stem cells are chara cterized by rapid proliferation and differentiation into neurons which allow for integration into neural *** review focuses on diffe rences between quiescent and active adult neural stem cells in nutrition metabolism and protein ***,we discuss the physiological significance and underlying advantages of these diffe *** to the limited number of adult neural stem cells studies,we refe rred to studies of embryonic adult neural stem cells or non-mammalian adult neural stem cells to evaluate specific mechanisms.

关键词： adult neurogenesis cell metabolic pathway cellular proliferation neural stem cell niches neural stem cells neuronal differentiation nutrient sensing pathway proteostasis

Hydrogel-Assisted Electrokinetics for High-Resolution and Non-invasive Flow Monitoring in Microfluidic Chips

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Chinese Journal of Chemistry 2024年第6期42卷 571-577页

作者： Na Zhao Yanni Ma Zehua Yu Jun Huang Xiangqian Fu Tao Qiu Kang Liu MOE Key Laboratory of Hydraulic Machinery Transients School of Power and Mechanical EngineeringWuhan UniversityWuhanHubei430072 China department of Urology Renmin Hospital of Wuhan UniversityWuhanHubei430072 China department of Organ Transplantation Renmin Hospital of Wuhan UniversityWuhanHubei430072 China

Convenient non-invasive flow monitoring would facilitate the operation and control in microfluidic chips,but is challenging due to the small space of microchannels and complex operation required in traditional optical *** this work,we propose a novel non-invasive strategy to probe microfluidic flows via streaming potential *** sealing one side of the microchannel with a piece of hydrogel film,streaming potential inside the channel can be clearly detected by electrodes at outer surface of the hydrogel due to ion diffusion in the *** is detected without sensors contacting with the internal ***,the electrodes shape like a tiny probe,which can move around mapping the flow distribution in a chip with the spatial resolution of 1 mm and flow rate detection limit of 3μL·min–*** inside the channels can also be detected,due to the fluctuation of streaming voltage when gas-liquid interface flows through the electrode,showing an easy and potential way for multi-functional flow monitoring in microfluidic chips.

关键词： Microfluidics Hydrogels Electrokinetics Flow monitoring Non-invasive Sensor Charge transport

α-Synuclein pathology from the body to the brain:so many seeds so close to the central soil

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Neural Regeneration Research 2024年第7期19卷 1463-1472页

作者： Yunying Yang Zhentao Zhang department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhanHubei ProvinceChina

α-Synuclein is a protein that mainly exists in the presynaptic *** folding and accumulation of α-synuclein are found in several neurodegenerative diseases,including Parkinson’s *** and highly phospho rylated a-synuclein constitutes the main component of Lewy bodies in the brain,the pathological hallmark of Parkinson s *** decades,much attention has been focused on the accumulation of α-synuclein in the brain parenchyma rather than considering Parkinson s disease as a systemic *** evidence demonstrates that,at least in some patients,the initial α-synuclein pathology originates in the peripheral organs and spreads to the *** of α-synuclein preformed fibrils into the gastrointestinal tra ct trigge rs the gutto-brain propagation of α-synuclein ***,whether α-synuclein pathology can occur spontaneously in peripheral organs independent of exogenous α-synuclein preformed fibrils or pathological α-synuclein leakage from the central nervous system remains under *** this review,we aimed to summarize the role of peripheral α-synuclein pathology in the pathogenesis of Parkinson’s *** also discuss the pathways by which α-synuclein pathology spreads from the body to the brain.

关键词： aggregation autonomic nervous system barrier receptors body fluid circulation in situ generation Parkinson’s disease phosphorylation propagation synucleinopathies α-synuclein α-synuclein fibrils

Mechanism of PARP inhibitor resistance and potential overcoming strategies

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Genes & Diseases 2024年第1期11卷 306-320页

作者： Xiaoyu Fu Ping Li Qi Zhou Ruyuan He Guannan Wang Shiya Zhu Amir Bagheri Gary Kupfer Huadong Pei Juanjuan Li department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA department of Breast and Thyroid Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430060China department of Thoracic Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China

PARP inhibitors(PARPi)are a kind of cancer therapy that targets poly(ADP-ribose)*** is the first clinically approved drug to exert synthetic lethality by obstruct-ing the DNA single-strand break repair *** the significant therapeutic effect in pa-tients with homologous recombination(HR)repair deficiency,innate and acquired resistance to PARPi is a main challenge in the *** this review,we mainly discussed the underlying mechanisms of PARPi resistance and summarized the promising solutions to overcome PARPi resistance,aiming at extending PARPi application and improving patient outcomes.

关键词： Drug resistance Homologous recombination PARP PARP inhibitor Poly(ADP-ribose)polymerase

A bibliometric analysis of 3D microfluidic chip in cancer

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Chinese Medical Journal 2024年第13期137卷 1617-1619页

作者： Yingyun Guo Chuan Liu Chen Tan Yangbo Li Junhai Zhen Haodong He Jiayi Sun Ying Chen Zongbiao Tan Yanrui Wu Suqi Zeng Pengzhan He Jixiang Zhang Fei Liao Weihua Huang Weiguo Dong department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China department of General Practice Renmin Hospital of Wuhan UniversityWuhanHubei 430060China College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China

To the Editor:Cancer,as one of the foremost health challenges in the world today,has garnered significant attention from the medical and scientific *** an emerging technology,3D microfluidic chips have shown great potentials in the treatment of various ***,we aimed to conduct a bibliometric analysis of the relevant literature on 3D microfluidic chips in cancer showcasing their current status,hotspots,and development trends.

关键词： fluid cancer Cancer

Oxalate regulates crystal-cell adhesion and macrophage metabolism via JPT2/PI3K/AKT signaling to promote the progression of kidney stones

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Journal of Pharmaceutical Analysis 2024年第6期14卷 851-862页

作者： Qianlin Song Chao Song Xin Chen Yunhe Xiong Ziqi He Xiaozhe Su Jiawei Zhou Hu Ke Caitao Dong Wenbiao Liao Sixing Yang department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan430060China

Oxalate is an organic dicarboxylic acid that is a common component of plant *** kidneys are essential organs for oxalate excretion,but excessive oxalates may induce kidney *** microtubule associated homolog 2(JPT2)is a critical molecule in Ca^(2+)mobilization,and its intrinsic mechanism in oxalate exposure and kidney stones remains *** study aimed to reveal the mechanism of JPT2 in oxalate exposure and kidney *** approaches were used to control JPT2 expression in cells and mice,and the JPT2 mechanism of action was analyzed using transcriptomics and untargeted *** results showed that oxalate exposure triggered the upregulation of JPT2,which is involved in nicotinic acid adenine dinucleotide phosphate(NAADP)-mediated Ca^(2+)*** analysis revealed that cell adhesion and macrophage inflammatory polarization were inhibited by JPT2 knockdown,and these were dominated by phosphatidylinositol 3-kinase(PI3K)/AKT signaling,*** metabolomics indicated that JPT2 knockdown inhibited the production of succinic acid semialdehyde(SSA)in ***,JPT2 deficiency in mice inhibited kidney stones *** conclusion,this study demonstrates that oxalate exposure facilitates kidney stones by promoting crystal-cell adhesion,and modulating macrophage metabolism and inflammatory polarization via JPT2/PI3K/AKT signaling.

关键词： Oxalate Kidney stones JPT2 Crystal-cell adhesion Immunoregulation