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Comparison of updated birth weight,length and head circumference charts by gestational age in China with the INTERGROWTH-21 st NCSS charts:a population-based study

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World Journal of pediatrics 2023年第1期19卷 96-105页

作者： Ya-Qin Zhang Hui Li Xin-Nan Zong Hua-Hong Wu department of Growth and Development Capital Institute of PediatricsNo.2Ya Bao RoadChaoyang DistrictBeijingChina

Background INTERGROWTH-21 st Newborn Cross-Sectional Study(NCSS)charts were established and recommended for global ***,whether one international reference is appropriate for all populations is still *** aim to compare the updated Chinese birth size charts by gestational age with INTERGROWTH-21st NCSS *** A cross-sectional survey was carried out,and the birth weight,length and head circumference of 24,375 infants born after uncomplicated pregnancies at gestational age ranging from 24+0 to 42+6 weeks were measured in 13 cities in China from 2015 to *** charts were *** measurements of all these infants were evaluated by the methods of calculating their Z scores using the INTERGROWTH-21 st *** prevalence of small for gestational age(SGA)and large for gestational age(LGA)based on birth weight was analyzed using Chinese charts and INTERGROWTH-21st *** The mean Z scores were 0.10 for birth weight,0.35 for length and-0.02 for head *** to the INTERGROWTH-21st charts,the Chinese birth weight percentile curves were higher except for the 90th percentile at 29-37 weeks gestational age,and the length percentile curves were higher after 33 weeks gestational age,while the 10th percentile of the head circumference was lower and the other percentiles were *** prevalence of SGA was 10.1%[95%confidence interval(CI)=9.7%-10.5%]using the Chinese birth weight chart and 6.5%(95%CI=6.2%-6.8%)using the INTERGROWTH-21 st birth weight *** prevalence of LGA was 9.9%(95%CI=9.5%-10.2%)and 8.2%(95%CI=7.9%-8.6%)using the Chinese and INTERGROWTH-21st birth weight charts,*** Chinese birth size charts based on infants born after uncomplicated pregnancies were different from the INTER-GROWTH-21st *** in the classification of newborns by the two charts should receive attention,and whether the application of INTERGROWTH-21st in Chinese newborns will lead to miscl

关键词： Birth length Birth weight Growth charts Head circumference Newborns

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Mycoplasma pneumoniae pneumonia in children

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World Journal of Clinical Cases 2025年第5期13卷 61-67页

作者： Thakoon Butpech Prakarn Tovichien department of pediatrics Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand

Mycoplasma pneumoniae(***)is a common pathogen that causes community-acquired pneumonia in *** clinical presentation of this pathogen can range from mild self-limiting illness to severe and refractory *** may occur,such as necrotizing pneumonia and respiratory *** complications,including encephalitis,myocarditis,nephritis,hepatitis,or even multiple organ failure,can also *** this editorial,we dis-cuss the clinical implications of the significant findings from the article"Serum inflammatory markers in children with *** pneumonia and their predictive value for mycoplasma severity"published by Wang et *** reported that measuring lactic dehydrogenase,interleukin-6 levels,and D-dimer effectively predicts refractory *** pneumonia cases.

关键词： Cytokine Mycoplasma pneumoniae pneumonia Children,Community-acquired pneumonia Lactic dehydrogenase Interleukin-6

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Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok Hwang Hyo-Jeong Jang department of pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

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Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World Journal of Clinical pediatrics 2025年第1期14卷 78-92页

作者： Hasan M Isa Marwa J Abdulnabi Nawra S Naser Fatema N Lahmda Noor M AlAnsari Zahra H Isa Afaf M Mohamed department of pediatrics Salmaniya Medical ComplexManama 26671Bahrain department of pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of Medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CMPA).AIM To evaluate CMPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CMPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya Medical Complex,Bahrain,between 2014 and 2022,and assessed CMPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the Mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CMPA and 595(96.3%)were included;CMPA prevalence was 2%.Most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CMPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(P24)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(P2)than non-IgE-mediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CMPA was associated with a longer follow-up duration than non-IgE-mediated CMPA(17.3 months±14.0 mo

关键词： Children Milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

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Physical rehabilitation for sensorineural hearing loss in childhood:Progress and challenges

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World Journal of Clinical Cases 2025年第7期13卷 57-62页

作者： Lu Zhang Pu-Jue Huang Xue Deng Jiao Tang Yang Zhai Tao Wang department of pediatrics Luzhou Maternal and Child Health HospitalLuzhou 646600Sichuan ProvinceChina department of pediatrics West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of pediatrics The First People's Hospital of Longquanyi DistrictChengdu 610100Sichuan ProvinceChina Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Chengdu 610041Sichuan ProvinceChina department of pediatrics Chengdu Women’s and Children’s Central HospitalChengdu 610000Sichuan ProvinceChina

Early intervention for sensorineural hearing loss(SNHL)in childhood is crucial for auditory and language *** recent years,innovative auditory stimulation techniques and speech therapy strategies,such as middle ear implants,cochlear implants,auditory brainstem implants,and midbrain implants,have provided new avenues for improving patient ***,basic research advancements in cell reprogramming and regeneration,stem cell therapy,and targeted drug delivery offer promising approaches to meet the individualized needs of children with ***,many challenges and unresolved issues remain in the treatment of *** article comments on the case report,which describes a female pediatric patient with SNHL who underwent foot reflexology which led to the normalization of hearing *** is considered to have potential benefits in physical rehabilitation,but its efficacy in hearing restoration requires further scientific validation through rigorous clinical trials and large-scale prospective studies.

关键词： Sensorineural hearing loss Childhood Physical rehabilitation therapy Recent advances in rehabilitation techniques Reflexology

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Congenital anomalies of coronary artery misdiagnosed as coronary dilatations in Kawasaki disease:A clinical predicament

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World Journal of Clinical pediatrics 2025年第1期14卷 93-100页

作者： Rakesh Kumar Pilania Pallavi L Nadig Suprit Basu Reva Tyagi Abarna Thangaraj Ridhima Aggarwal Munish Arora Arun Sharma Surjit Singh Manphool Singhal Pediatric Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CenterPost Graduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia

BACKGROUND 2D-echocardiography(2DE)has been the primary imaging modality in children with Kawasaki disease(KD)to assess coronary *** To report the presence and implications of incidental congenital coronary artery anomalies that had been misinterpreted as coronary artery abnormalities(CAAs)on *** Records of children diagnosed with KD,who underwent computed tomography coronary angiography(CTCA)at our center between 2013-2023 were *** identified 3 children with congenital coronary artery anomalies in this cohort on *** of CTCA and 2DE were compared in these 3 *** Of the 241 patients with KD who underwent CTCA,3(1.24%)had congenital coronary artery anomalies on CTCA detected *** all 3 patients,baseline 2DE had identified *** was then performed for detailed evaluation as per our unit ***(11-year-boy)amongst the 3 patients had complete KD,while the other two(3.3-year-boy;4-month-girl)had incomplete *** revealed separate origins of left anterior descending artery and left circumflex from left sinus[misinterpreted as dilated left main coronary artery(LCA)on 2DE],single coronary artery(interpreted as dilated LCA on 2DE)and dilated right coronary artery on 2DE in case of anomalous origin of LCA from the main pulmonary *** latter one was subsequently operated *** CTCA is essential for detailed assessment of coronary arteries in children with KD especially in cases where there is suspicion of congenital coronary artery *** solely on 2DE may not be sufficient in such cases,and findings from CTCA can significantly impact therapeutic decision-making.

关键词： Coronary artery abnormalities Congenital coronary artery anomalies Computed tomography coronary angiography Kawasaki disease 2-dimensional echocardiography

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy department of Surgery Morehouse School of MedicineAtlantaGAUSA department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA department of pediatrics Emory UniversityAtlantaGAUSA department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Renal glucosuria in children

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World Journal of Clinical pediatrics 2025年第1期14卷 46-54页

作者： Meral Torun Bayram Salih Kavukcu Division of Nephrology Department of PediatricsDokuz Eylül UniversitySchool of MedicineInciralti-Balcova 35340IzmirTürkiye

The kidneys play a critical role in maintaining glucose *** normal renal tubular function,most of the glucose filtered from the glomeruli is re-absorbed in the proximal tubules,leaving only trace amounts in the *** can occur as a symptom of generalized proximal tubular dysfunction or when the reabsorption threshold is exceeded or the glucose threshold is reduced,as seen in familial renal glycosuria(FRG).FRG is characterized by persistent glycosuria despite normal blood glucose levels and tubular function and is primarily associated with mutations in the sodium/glucose cotransporter 5A2 gene,which encodes the sodium-glucose cotransporter(SGLT)*** SGLTs has been proposed as a novel treatment strategy for diabetes,and since FRG is often considered an asymptomatic and benign condition,it has inspired preclinical and clinical studies using SGLT2 inhibitors in type 2 ***,patients with FRG may exhibit clinical features such as lower body weight or height,altered systemic blood pressure,diaper dermatitis,amino-aciduria,decreased serum uric acid levels,and *** research is needed to fully understand the pathophysiology,molecular genetics,and clinical manifestations of renal glucosuria.

关键词： Sodium-glucose cotransporters Basolateral glucose transporters Familial renal glucosuria Intestinal glucose-galactose malabsorption Fanconi-Bickel syndrome Sodium-glucose cotransporter 2 inhibitors

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Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats

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Current Medical Science 2021年第3期41卷 548-554页

作者： Qing ZHANG Jing WANG Liang ZHU Shi-jie JIANG Juan LIU Lin-xiao WANG Xi-hu QIN Laboratory of Neurological Diseases the Afiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213003China department of pediatrics the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213003China department of Anesthesiology the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChanghow 213003China department of Orthopedics the Affliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangehou 213003China department of Endocrinology the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213003China department of General Surgery the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213000China

Ligustrazine,an alkaloid extracted from the traditional Chinese herbal medicine Ligusticum Chuanxiong Hort,has been clinically applied to treat the cerebrovascular ***(Hhcy)is an independent risk factor for Alzheimer's disease(AD).Memory deficits can be caused by Hhcy via pathologies of Aβ-like tau and amyloid-β(Aβ)in the ***,we investigated whether homocysteine(Hey)can induce Aβ-like pathologies and the effects of ligustrazine on these *** Hey rat model was constructed by 14-day Hey injection via vena caudalis,and rats were treated with daily intragastric administration of ligustrazine at the same *** found that the pathologies of tau and Aβ were induced by Hey in the hippocampus,while the Hcy-induced tau hyperphosphorylation and Aβ accumulation could be markedly attenuated by simultaneous ligustrazine *** data demonstrate that ligustrazine may be used as a promising neuroprotective agent to treat the Hcy-induced Aβ-like pathologies.

关键词： Alzheimer's disease ligustrazine hyperhomocysteinemia phosphorylated tau cognitive impairment

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Intestinal microbiota and juvenile idiopathic arthritis:current understanding and future prospective

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World Journal of pediatrics 2021年第1期17卷 40-51页

作者： Le Xin Feng He Sen Li Zhi-Xuan Zhou Xiao-Lin Ma Gynecological Minimal Invasive Center Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijingChina department of Biochemistry and Immunology Capital Institute of PediatricsYabao Road No.2Chaoyang DistrictBeijingChina department of Rheumatology Capital Institute of PediatricsBeijingChina

Background Juvenile idiopathic arthritis(JIA)characterized by arthritis of unknown origin is the most common childhood chronic rheumatic disease,caused by both host genetic factors and environmental *** evidence has mounted to focus on the intestinal microbiota,a potentially recognized set of environmental triggers affecting JIA *** we offer an overview of recently published animal and human studies that support the impact of intestinal microbiota in *** sources We searched PubMed for animal and human studies publications with the search terms"intestinal microbiota or gut microbiota"and"juvenile idiopathic arthritis or juvenile chronic arthritis or juvenile rheumatoid arthritis or childhood rheumatoid arthritis or pediatric rheumatoid arthritis".Results Several comparative studies have demonstrated that intestinal microbial alterations might be triggers in disease ***,a slice of studies has suggested environmental triggers in early life might disrupt intestinal microbial colonization,including cesarean section,formula feeding,and antibiotic *** intestinal microbiota may influence the development of JIA by mediating host immune programming and by altering mucosal *** Specific microbial factors may contribute to the pathogenesis of *** studies,however,are warranted to investigate the causality between intestinal dysbiosis and JIA and the mechanisms behind these epidemiologic *** are also needed to design the best interventional administrations to restore balanced intestinal microbial communities.

关键词： Antibiotic exposure Cesarean section Immune system reprogramming Intestinal microbiota Juvenile idiopathic arthritis

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