Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats
作者机构：Laboratory of Neurological Diseasesthe Afiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213003China Department of Pediatricsthe Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213003China Department of Anesthesiologythe Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChanghow 213003China Department of Orthopedicsthe Affliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangehou 213003China Department of Endocrinologythe Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213003China Department of General Surgerythe Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213000China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2021年第41卷第3期
页 面：548-554页
核心收录：
基 金：grants from Changzhou Sci&Tech Program(No.CJ20190063,No.CJ20200090) Young Talent Development Plan of Changzhou Health Commission(No.CZQM2020078,and No.CZQM2020063) China Postdoctoral Science Foundation(No.2020M670012ZX) National Natural Science Foundation of China(No.81803498) Jiangsu Planned Projects for Postdoctoral Research Funds(No.2019K157) "Mass Entrepreneurship and Innovation Plan"of Jiangsu Province(No.QT201919)
主 题：Alzheimer's disease ligustrazine hyperhomocysteinemia phosphorylated tau cognitive impairment
摘 要：Ligustrazine,an alkaloid extracted from the traditional Chinese herbal medicine Ligusticum Chuanxiong Hort,has been clinically applied to treat the cerebrovascular ***(Hhcy)is an independent risk factor for Alzheimer s disease(AD).Memory deficits can be caused by Hhcy via pathologies of Aβ-like tau and amyloid-β(Aβ)in the ***,we investigated whether homocysteine(Hey)can induce Aβ-like pathologies and the effects of ligustrazine on these *** Hey rat model was constructed by 14-day Hey injection via vena caudalis,and rats were treated with daily intragastric administration of ligustrazine at the same *** found that the pathologies of tau and Aβ were induced by Hey in the hippocampus,while the Hcy-induced tau hyperphosphorylation and Aβ accumulation could be markedly attenuated by simultaneous ligustrazine *** data demonstrate that ligustrazine may be used as a promising neuroprotective agent to treat the Hcy-induced Aβ-like pathologies.
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