Renal glucosuria in children

作     者：Meral Torun Bayram Salih Kavukcu 

作者机构：Division of NephrologyDepartment of PediatricsDokuz Eylül UniversitySchool of MedicineInciralti-Balcova 35340IzmirTürkiye 

出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志（英文）)

年 卷 期：2025年第14卷第1期

页      面：46-54页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Sodium-glucose cotransporters Basolateral glucose transporters Familial renal glucosuria Intestinal glucose-galactose malabsorption Fanconi-Bickel syndrome Sodium-glucose cotransporter 2 inhibitors 

摘      要：The kidneys play a critical role in maintaining glucose *** normal renal tubular function,most of the glucose filtered from the glomeruli is re-absorbed in the proximal tubules,leaving only trace amounts in the *** can occur as a symptom of generalized proximal tubular dysfunction or when the reabsorption threshold is exceeded or the glucose threshold is reduced,as seen in familial renal glycosuria(FRG).FRG is characterized by persistent glycosuria despite normal blood glucose levels and tubular function and is primarily associated with mutations in the sodium/glucose cotransporter 5A2 gene,which encodes the sodium-glucose cotransporter(SGLT)*** SGLTs has been proposed as a novel treatment strategy for diabetes,and since FRG is often considered an asymptomatic and benign condition,it has inspired preclinical and clinical studies using SGLT2 inhibitors in type 2 ***,patients with FRG may exhibit clinical features such as lower body weight or height,altered systemic blood pressure,diaper dermatitis,amino-aciduria,decreased serum uric acid levels,and *** research is needed to fully understand the pathophysiology,molecular genetics,and clinical manifestations of renal glucosuria.