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Treatment of critical bone defects using calcium phosphate cement and mesoporous bioactive glass providing spatiotemporal drug delivery

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Bioactive Materials 2023年第10期28卷 402-419页

作者： Richard Frank Richter Corina Vater Margarete Korn Tilman Ahlfeld Martina Rauner Winnie Pradel Bernd Stadlinger Michael Gelinsky Anja Lode Paula Korn Centre for Translational Bone Joint and Soft Tissue ResearchUniversity Hospital Carl Gustav Carus and Faculty of MedicineTechnische Universitat DresdenDresdenGermany department of oral and maxillofacial surgery University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany department of Medicine III and Center for Healthy Aging University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany Clinic of Cranio-maxillofacial and oral surgery Center of Dental MedicineUniversity of ZurichSwitzerland

Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.

关键词： Drug delivery 3D plotting Alveolar cleft defect Calcium phosphate cement Mesoporous bioactive glass

Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN

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International Journal of oral Science 2022年第4期14卷 470-478页

作者： Weilian Liang Yang Chen Hanzhe Liu Hui Zhao Tingting Luo Hokeung Tang Xiaocheng Zhou Erhui Jiang Zhe Shao Ke Liu Zhengjun Shang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory for oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Shenzhen PKU-HKUST Medical Center(Peking University Shenzhen Hospital) ShenzhenChina department of oral and maxillofacial surgery School and Hospital of StomatologyWuhan UniversityWuhanChina department of oral and maxillofacial-Head and Neck oncology School&Hospital of StomatologyWuhan UniversityWuhanChina

Tumor volume increases continuously in the advanced stage, and aside from the self-renewal of tumor cells, whether the oncogenic transformation of surrounding normal cells is involved in this process is currently unclear. Here, we show that oral squamous cell carcinoma(OSCC)-derived small extracellular vesicles(s EVs) promote the proliferation, migration, invasion, and epithelial-mesenchymal transition(EMT) of normal epithelial cells but delay their apoptosis. In addition, nuclear-cytoplasmic invaginations and multiple nucleoli are observed in s EV-treated normal cells, both of which are typical characteristics of premalignant lesions of OSCC. Mechanistically, mi Rlet-7c in OSCC-derived s EVs is transferred to normal epithelial cells, leading to the transcriptional inhibition of p53 and inactivation of the p53/PTEN pathway. In summary, we demonstrate that OSCC-derived s EVs promote the precancerous transformation of normal epithelial cells, in which the mi R-let-7c/p53/PTEN pathway plays an important role. Our findings reveal that cancer cells can corrupt normal epithelial cells through s EVs, which provides new insight into the progression of OSCC.

关键词： cor invasion transferred

Application of digital positioning guide plates for the surgical extraction of multiple impacted supernumerary teeth:A case report and review of literature

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World Journal of Clinical Cases 2022年第27期10卷 9886-9896页

作者： Zhi Wang Shu-Yi Zhao Wu-Shu He Fan Yu Shao-Jie Shi Xue-Ling Xia Xin-Xiao Luo Yu-Hong Xiao department of oral and maxillofacial surgery 920th Hospital of Joint Logistics Support ForcePLATeaching Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND An extra tooth in the normal tooth sequence in any region of the dental arch is regarded as a supernumerary tooth(SNT).Due to the large variation in location and morphology,the extraction of impacted SNTs is an extensive and complex procedure with high risks of several *** report presents a rare case of seven impacted SNTs in the bilateral upper and lower arch that were successfully extracted with the use of digital positioning guide *** SUMMARY In January 2022,a 21-year-old male was referred to our department with a chief complaint of pain in relation to tooth#*** examination showed a deep carious lesion with pulpal involvement in tooth#36 and lingual swelling of the bilateral mandibular posterior *** examination revealed seven deeply impacted SNTs in the bilateral posterior area and bilateral impacted mandibular third *** on these findings,the patient was diagnosed with bilateral,multiple impacted SNTs and tooth#36 chronic pulpitis.A root canal treatment and an all-ceramic crown restoration for tooth#36 were *** individualized digital positioning guide plate was designed by computer-aided design/computer-aided manufacturing technology and cone-beam computed tomography for extraction of the impacted *** the operation,the digital positioning guide plate allowed rapid positioning and exposure of the SNTs while avoiding adjacent important anatomical *** 3-month follow-up,regeneration of bone and soft tissues was *** The application of digital positioning guide plates is useful for the individualized and minimalized extraction of impacted supernumerary teeth.

关键词： Supernumerary teeth Computer aided design/computer aided manufacturing Digital Surgical guide Minimal invasion Case report

Metabolic activity of Streptococcus mutans biofilms and gene expression during exposure to xylitol and sucrose

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International Journal of oral Science 2014年第4期6卷 195-204页

作者： Eva-Maria Decker Christian Klein Dimitri Schwindt Christiane von Ohle department for Pediatric and Operative Dentistry Periodontology and Endodontology Center of Dentistry Oral Medicine and Maxillofacial Surgery University of Tbingen Private Practice Zahngesundheit Waiblingen

The objective of the study was to analyse Streptococcus mutans biofilms grown under different dietary conditions by using multifaceted methodological approaches to gain deeper insight into the cariogenic impact of carbohydrates. S. mutans biofilms were generated during a period of 24 h in the following media： Schaedler broth as a control medium containing endogenous glucose, Schaedler broth with an additional 5% sucrose, and Schaedler broth supplemented with 1% xylitol. The confocal laser scanning microscopy（CLSM）-based analyses of the microbial vitality, respiratory activity（5-cyano-2,3-ditolyl tetrazolium chloride, CTC） and production of extracellular polysaccharides（EPS） were performed separately in the inner, middle and outer biofilm layers. In addition to the microbiological sample testing, the glucose/sucrose consumption of the biofilm bacteria was quantified, and the expression of glucosyltransferases and other biofilm-associated genes was investigated. Xylitol exposure did not inhibit the viability of S. mutans biofilms, as monitored by the following experimental parameters： culture growth, vitality, CTC activity and EPS production. However,xylitol exposure caused a difference in gene expression compared to the control. Gtf C was upregulated only in the presence of *** xylitol exposure, gtf B was upregulated by a factor of 6, while under sucrose exposure, it was upregulated by a factor of *** with glucose and xylitol, sucrose increased cell vitality in all biofilm layers. In all nutrient media, the intrinsic glucose was almost completely consumed by the cells of the S. mutans biofilm within 24 h. After 24 h of biofilm formation, the multiparametric measurements showed that xylitol in the presence of glucose caused predominantly genotypic differences but did not induce metabolic differences compared to the control. Thus, the availability of dietary carbohydrates in either a pure or combined form seems to affect the cariogenic potential of

关键词： biofilms 5-cyano-2 3-ditolyl tetrazolium chloride extracellular polysaccharides gene expression Streptococcus mutans sucrose viability xylitol

Differential mRNA expression in peripheral blood is associated with oral squamous cell carcinoma:Recent advances and future challenges

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BIOCELL 2023年第7期47卷 1449-1458页

作者： XIA MU YUBING HU DANDAN WU HONGYU YANG department of Stomatology Zunyi Medical UniversityZunyi563000China department of oral and maxillofacial surgery Peking University Shenzhen Hospital Stomatology CenterShenzhen518000China department of Nursing Henan UniversityKaifeng475000China

oral squamous cell carcinoma(OSCC)is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial *** OSCC-related biomarkers have been reported in circulation in the peripheral blood that support the occurrence and development of *** advances in high-throughput and highly sensitive detection methods have overcome the limitation of the low concentration of most peripheral blood ***,blood biomarker detection has become an efficient screening tool for the early diagnosis of *** growing data available in public cancer and gene databases have provided new foundations for OSCC *** particular,the identification of OSCC biomarkers using bioinformatic tools has shed new light on the underlying mechanisms as well as on the genetic landscape of *** recently,mRNA targeting therapies have emerged as valuable anticancer treatment strategies,as they allow for the regulation of the expression of certain functional proteins to reverse genetic abnormalities or induce tissue ***,mRNA-targeting therapies can be used to regulate the expression of antigens,antibodies,or cellular receptors by immune ***,anti-cancer cellular immunotherapy carrying specific mRNAs has attracted significant attention in OSCC ***,we review the present knowledge on the role of peripheral blood mRNAs in the diagnosis,treatment,development,and prognosis of ***,we address future research prospects of mRNAs in the peripheral blood in OSCC and the opportunities and challenges that may arise in future clinical therapeutic applications.

关键词： Diagnosis mRNA therapy Peripheral blood biomarker

NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1797-1807页

作者： Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang department of oral and maxillofacial-Head Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Research Unit of oral and maxillofacial Regenerative Medicine Chinese Academy of Medical SciencesShanghaiChina department of oral and maxillofacial surgery Zhang Zhiyuan Academician WorkstationHainan Western Central HospitalShanghai Ninth People’s HospitalDanzhouHainanChina department of oral and maxillofacial surgery The Second Xiangya Hospital of Central South UniversityChangshaHunanChina department of oral Pathology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Occupational Health Third Military Medical UniversityChongqingChina department of Pathology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina department of oral and maxillofacial surgery Affiliated Hospital of Guilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical UniversityChongqingChina and 10Department of Emergency MedicineFirst Affiliated Hospital and Department of Environmental MedicineSchool of Public HealthSchool of MedicineZhejiang UniversityHangzhouZhejiangChina

oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of *** is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain *** our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.

关键词： metastasis squamous prognosis

Epidemiology of maxillofacial Trauma in Pediatric and Adolescent Population: An Institutional Experience of 6 Years

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Open Journal of Orthopedics 2022年第6期12卷 277-287页

作者： Noaman Kazi Pallavi Ranadive Suday Rajurkar Ankit Sharma Mohan Deshpande Snehal Ingole department of oral and maxillofacial surgery M. A. Rangoonwala College of Dental Sciences & Research Centre Pune India department of oral and maxillofacial surgery Nair Hospital Dental College Mumbai India Consultant Oral and Maxillofacial Surgery Nagpur India department of oral and maxillofacial surgery Pacific Dental College Udaiur India

Introduction: Facial fractures are uncommon injuries in children. Pediatric maxillofacial fractures constitute 1% to 15% of all facial fractures, but show different clinical features when compared with adult patients. Worldwide, the major causes of fractures in children are accidents, falls, violence, and sports- related accidents. Facial trauma in children may result in injury to the facial growth centers, leading to subsequent developmental abnormalities in the injured area. Patients & Methods: Data of pediatric and adolescent patients (0 - 17 years), with a history of trauma, has been compiled over a period of 6 years. History, clinical and radiographic data records were analyzed. Compilation was done in the following categories;age and sex distribution, etiology, site of trauma and associated soft tissue injuries were recorded. The treatment rendered has also been mentioned. Results: A total of 340 patient records were assessed. Demographic data, etiology, type of fracture, associated injury and treatment rendered were recorded. It was found that males (54.7%) were more frequently affected than females (45.3%). Incidence of trauma was more in children belonging to the pre-school age group (38.5%) and the most common etiology was sports-related injuries (43.8%). Dentoalveolar fractures were the most common type (58.5%) of fractures seen in the patients. Most of the patients were managed by conservative treatment (35%) or closed reduction (48%), while a few required open reduction (7.9%). Conclusion: It is felt that this data will be useful in determining the pattern and etiology of maxillofacial trauma in pediatric patients in an Indian setting. Additionally, an outline of the treatment plan in different types of fractures is also summarized.

关键词： maxillofacial Trauma Pediatric Trauma Open Reduction Closed Reduction Mandibular Fractures

oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10

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International Journal of oral Science 2023年第4期15卷 718-728页

作者： Qingxiang Li Yuke Li Qiao Qiao Ning Zhao Yuanning Yang Lin Wang Yifei Wang Chuanbin Guo Yuxing Guo department of oral and maxillofacial surgery Peking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina

Recent studies have suggested that long-term application of anti-angiogenic drugs may impair oral mucosal wound *** study investigated the effect of sunitinib on oral mucosal healing impairment in mice and the therapeutic potential of Bifidobacterium breve(***).A mouse hard palate mucosal defect model was used to investigate the influence of sunitinib and/or zoledronate on wound *** volume and density of the bone under the mucosal defect were assessed by micro-computed tomography(micro-CT).Inflammatory factors were detected by protein microarray analysis and enzyme-linked immunosorbent assay(ELISA).The senescence and biological functions were tested in oral mucosal stem cells(OMSCs)treated with *** loop experiments were used to investigate the effect of oral *** antibody for interleukin-10(IL-10)was used to prove the critical role of IL-10 in the pro-healing process derived from *** showed that sunitinib caused oral mucosal wound healing impairment in *** vitro,sunitinib induced cellular senescence in OMSCs and affected biological functions such as proliferation,migration,and *** administration of *** reduced oral mucosal inflammation and promoted wound healing via intestinal dendritic cells(DCs)-derived ***-10 reversed cellular senescence caused by sunitinib in OMSCs,and IL-10 neutralizing antibody blocked the ameliorative effect of *** on oral mucosal wound healing under sunitinib treatment *** conclusion,sunitinib induces cellular senescence in OMSCs and causes oral mucosal wound healing impairment and oral administration of *** could improve wound healing impairment via intestinal DCs-derived IL-10.

关键词： healing wound mucosal

Therapeutic potential of dental pulp stem cells and their derivatives:Insights from basic research toward clinical applications

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World Journal of Stem Cells 2022年第7期14卷 435-452页

作者： Sheng-Meng Yuan Xue-Ting Yang Si-Yuan Zhang Wei-Dong Tian Bo Yang State Key Laboratory of oral Diseases National Clinical Research Center for Oral DiseasesEngineering Research Center of Oral Translational MedicineNational Engineering Laboratory for Oral Regenerative MedicineWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina department of oral and maxillofacial surgery West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina

For more than 20 years,researchers have isolated and identified postnatal dental pulp stem cells(DPSCs)from different teeth,including natal teeth,exfoliated deciduous teeth,healthy teeth,and diseased *** mesenchymal stem cell(MSC)-like immunophenotypic characteristics,high proliferation rate,potential for multidirectional differentiation and biological features were demonstrated to be superior to those of bone marrow *** addition,several main application forms of DPSCs and their derivatives have been investigated,including stem cell injections,modified stem cells,stem cell sheets and stem cell *** vitro and in vivo administration of DPSCs and their derivatives exhibited beneficial effects in various disease models of different tissues and ***,DPSCs and their derivatives are regarded as excellent candidates for stem cell-based tissue *** this review,we aim to provide an overview of the potential application of DPSCs and their derivatives in the field of regenerative *** describe the similarities and differences of DPSCs isolated from donors of different ages and health *** methodologies for therapeutic administration of DPSCs and their derivatives are introduced,including single injections and the transplantation of the cells with a support,as cell sheets,or as cell *** also summarize the underlying mechanisms of the regenerative potential of DPSCs.

关键词： Dental pulp stem cells Cell injections Modified cells Cell sheets Cell spheroids Regeneration