Therapeutic potential of dental pulp stem cells and their derivatives:Insights from basic research toward clinical applications

作     者：Sheng-Meng Yuan Xue-Ting Yang Si-Yuan Zhang Wei-Dong Tian Bo Yang 

作者机构：State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesEngineering Research Center of Oral Translational MedicineNational Engineering Laboratory for Oral Regenerative MedicineWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第7期

页      面：435-452页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China,No. U21A20369 Sichuan Science and Technology Program,No. 2021YJ0147 Research and Develop Program,West China Hospital of Stomatology Sichuan University,No. RD-02-202113 

主　　题：Dental pulp stem cells Cell injections Modified cells Cell sheets Cell spheroids Regeneration 

摘      要：For more than 20 years,researchers have isolated and identified postnatal dental pulp stem cells(DPSCs)from different teeth,including natal teeth,exfoliated deciduous teeth,healthy teeth,and diseased *** mesenchymal stem cell(MSC)-like immunophenotypic characteristics,high proliferation rate,potential for multidirectional differentiation and biological features were demonstrated to be superior to those of bone marrow *** addition,several main application forms of DPSCs and their derivatives have been investigated,including stem cell injections,modified stem cells,stem cell sheets and stem cell *** vitro and in vivo administration of DPSCs and their derivatives exhibited beneficial effects in various disease models of different tissues and ***,DPSCs and their derivatives are regarded as excellent candidates for stem cell-based tissue *** this review,we aim to provide an overview of the potential application of DPSCs and their derivatives in the field of regenerative *** describe the similarities and differences of DPSCs isolated from donors of different ages and health *** methodologies for therapeutic administration of DPSCs and their derivatives are introduced,including single injections and the transplantation of the cells with a support,as cell sheets,or as cell *** also summarize the underlying mechanisms of the regenerative potential of DPSCs.