Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10

作     者：Qingxiang Li Yuke Li Qiao Qiao Ning Zhao Yuanning Yang Lin Wang Yifei Wang Chuanbin Guo Yuxing Guo Qingxiang Li;Yuke Li;Qiao Qiao;Ning Zhao;Yuanning Yang;Lin Wang;Yifei Wang;Chuanbin Guo;Yuxing Guo

作者机构：Department of Oral and Maxillofacial SurgeryPeking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2023年第15卷第4期

页      面：718-728页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by the Clinical Medicine Plus X-Young Scholars Project of Peking University of the Fundamental Research Funds for the Central Universities (PKU2023LCXQ035) the Chinese Academy of Medical Sciences Central Public-Interest Scientific Institution Basal Research Fund (2022-JKCS-27) the National clinical key discipline construction project (PKUSSNKP-202114) China Postdoctoral Science Foundation (2022M720289) Chinese Stomatological Association Clinical Research Fund (CSA-SIS2022-01) National Natural Science Foundation of China (82301024) 

主　　题：healing wound mucosal 

摘      要：Recent studies have suggested that long-term application of anti-angiogenic drugs may impair oral mucosal wound *** study investigated the effect of sunitinib on oral mucosal healing impairment in mice and the therapeutic potential of Bifidobacterium breve(***).A mouse hard palate mucosal defect model was used to investigate the influence of sunitinib and/or zoledronate on wound *** volume and density of the bone under the mucosal defect were assessed by micro-computed tomography(micro-CT).Inflammatory factors were detected by protein microarray analysis and enzyme-linked immunosorbent assay(ELISA).The senescence and biological functions were tested in oral mucosal stem cells(OMSCs)treated with *** loop experiments were used to investigate the effect of oral *** antibody for interleukin-10(IL-10)was used to prove the critical role of IL-10 in the pro-healing process derived from *** showed that sunitinib caused oral mucosal wound healing impairment in *** vitro,sunitinib induced cellular senescence in OMSCs and affected biological functions such as proliferation,migration,and *** administration of *** reduced oral mucosal inflammation and promoted wound healing via intestinal dendritic cells(DCs)-derived ***-10 reversed cellular senescence caused by sunitinib in OMSCs,and IL-10 neutralizing antibody blocked the ameliorative effect of *** on oral mucosal wound healing under sunitinib treatment *** conclusion,sunitinib induces cellular senescence in OMSCs and causes oral mucosal wound healing impairment and oral administration of *** could improve wound healing impairment via intestinal DCs-derived IL-10.