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Journal of Thermal Science 2024年第2期33卷 509-521页

作者： Mojtaba TAHERI Fathollah POURFAYAZ Roghayeh HABIBI Akbar MALEKI department of Renewable Energies and Environment Faculty of New Sciences and TechnologiesUniversity of TehranTehran***Iran Faculty of Mechanical Engineering Shahrood University of TechnologyShahrood***Iran

Thermal energy storage(TES) is of great importance in solving the mismatch between energy production and *** this regard,choosing type of Phase Change Materials(PCMs) which are widely used to control heat in latent thermal energy storage systems,plays a vital role as a means of TES ***,this field suffers from lack of a comprehensive investigation on the impact of various PCMs in terms of *** address this issue,in this study,in addition to indicating the melting temperature and latent heat of various PCMs,the exergy destruction and exergy efficiency of each material are estimated and compared with each ***,in the present work the impact of PCMs mass and ambient temperature on the exergy efficiency is *** results proved that higher latent heat does not necessarily lead to higher exergy ***,to obtain a suitable exergy efficiency,the specific heat capacity and melting temperature of the PCMs must also be *** to the results,LiF-CaF_(2)(80.5%:19.5%,mass ratio) mixture led to better performance with satisfactory exergy efficiency(98.84%) and notably lower required mass compared to other ***,the highest and lowest exergy destruction are belonged to GR25 and LiF-CaF_(2)(80.5:19.5) mixture,respectively.

关键词： exergy analysis phase change materials thermal energy storage exergy efficiency

Antisense therapy:a potential breakthrough in the treatment of neurodegenerative diseases

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Neural Regeneration Research 2024年第5期19卷 1027-1035页

作者： Roberta Romano Cecilia Bucci department of Biological and Environmental sciences and technologies(DiSTeBA) University of SalentoLecceItaly

Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central or peripheral nervous ***,there is no cure for neurodegenerative diseases and this means a heavy burden for patients and the health system ***,it is necessary to find new therapeutic approaches,and antisense therapies offer this possibility,having the great advantage of not modifying cellular genome and potentially being *** preclinical and clinical studies aim to test the safety and effectiveness of antisense therapies in the treatment of neurodegenerative *** objective of this review is to summarize the recent advances in the development of these new technologies to treat the most common neurodegenerative diseases,with a focus on those antisense therapies that have already received the approval of the *** and Drug Administration.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis antisense oligonucleotide Huntington’s disease neurodegenerative disorders Parkinson’s disease siRNA

Effectiveness of hybrid ensemble machine learning models for landslide susceptibility analysis:Evidence from Shimla district of North-west Indian Himalayan region

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Journal of Mountain Science 2024年第7期21卷 2368-2393页

作者： SHARMA Aastha SAJJAD Haroon RAHAMAN Md Hibjur SAHA Tamal Kanti BHUYAN Nirsobha department of Geography Faculty of SciencesJamia Millia IslamiaNew Delhi-110025India

The Indian Himalayan region is frequently experiencing climate change-induced ***,landslide susceptibility assessment assumes greater significance for lessening the impact of a landslide *** paper makes an attempt to assess landslide susceptibility in Shimla district of the northwest Indian Himalayan *** examined the effectiveness of random forest(RF),multilayer perceptron(MLP),sequential minimal optimization regression(SMOreg)and bagging ensemble(B-RF,BSMOreg,B-MLP)models.A landslide inventory map comprising 1052 locations of past landslide occurrences was classified into training(70%)and testing(30%)*** site-specific influencing factors were selected by employing a multicollinearity *** relationship between past landslide occurrences and influencing factors was established using the frequency ratio *** effectiveness of machine learning models was verified through performance *** landslide susceptibility maps were validated by the area under the receiver operating characteristic curves(ROC-AUC),accuracy,precision,recall and *** key performance metrics and map validation demonstrated that the BRF model(correlation coefficient:0.988,mean absolute error:0.010,root mean square error:0.058,relative absolute error:2.964,ROC-AUC:0.947,accuracy:0.778,precision:0.819,recall:0.917 and F-1 score:0.865)outperformed the single classifiers and other bagging ensemble models for landslide *** results show that the largest area was found under the very high susceptibility zone(33.87%),followed by the low(27.30%),high(20.68%)and moderate(18.16%)susceptibility *** factors,namely average annual rainfall,slope,lithology,soil texture and earthquake magnitude have been identified as the influencing factors for very high landslide *** texture,lineament density and elevation have been attributed to high and moderate ***,the study calls for devising suitable landslide mitig

关键词： Landslide susceptibility Site-specific factors Machine learning models Hybrid ensemble learning Geospatial techniques Himalayan region

Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

Optimal site selection for geothermal heated greenhouses in cold climates:a fuzzy logic and geographic information system approach

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Clean Energy 2024年第2期8卷 8-26页

作者： Amirhossein Mirabadi Saeid Minaei Younes Noorollahi Morteza Almasi department of Agricultural Systems Science and Research BranchIslamic Azad UniversityTehranIran Biosystems Engineering department Faculty of AgricultureTarbiat Modares UniversityTehranIran Energy Modelling and Sustainable Energy System(METSAP)Research Lab. Faculty of New Sciences and TechnologiesUniversity of TehranIran

This paper presents a comprehensive model for selecting optimal sites for geothermal heated greenhouses in the agricultural *** research involves two main components:assessing the geothermal energy resource using geological,geochemical and geophysical indicators;and developing a siting model based on fuzzy logic that considers technical,environmental and socio-economic fac*** study focuses on East Azerbaijan province in Iran-a cold *** results indicate that~3.24%of the total area of the province is suitable for constructing geothermal greenhouses,resulting in potential savings of~148000 and 745978 m3 of natural gas in areas with high and very high suitability,respectively.

关键词： geothermal energy site selection GIS fuzzy logic resource assessment

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 319-330页

作者： Priya Bhardwaj Swarnabha Sarkar Ritu Mishra department of Pharmacology All India Institute of Medical SciencesNew Delhi-110029India department of Physiology All India Institute of Medical SciencesNew Delhi-110029India department of Zoology University of AllahabadPrayagrajUttar Pradesh-211002India

The recently re-emerged mpox(monkeypox)virus that causes mpox disease is a member of genus Orthopoxvirus and has unprecedentedly spread *** studies have contributed to our understanding of its evolution,pathophysiology,and clinical *** current outbreak of the mpox virus depicts its novel route of transmission as a new ***,the exact reason for its transition from an epidemic to a pandemic remains ***,other poxviruses such as vaccinia virus,variola virus,and cowpox virus,also belong to the same genus,*** the present review,our objective was to summarize the evidence on evolution,pathophysiology,and clinical manifestations of mpox virus and its related *** present review would aid in a better understanding of the current circulating mpox virus and its differences from other *** addition,the shared genetic factors contributing to virulence in these Orthopoxvirus highlight their evolutionary connections and genetic *** they exhibit differences in virulence,studying these genetic relationships is crucial for understanding their biology,pathogenicity,and the development of effective vaccines and antiviral therapeutics to curb mpox disease.

关键词： Evolution Mpox Orthopoxviruses Pathophysiology Poxviruses Transmission

Assessment of the implementation status of best available techniques for cleaner production in the textile industry

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 133-148页

作者： Mehmet Eren Yaman Emrah Ozturk Ulku Yetis Mehmet Kitis department of Environmental Engineering Suleyman Demirel UniversityIsparta 32260Turkey department of Environmental Protection technologies Isparta University of Applied SciencesIsparta 32200Turkey department of Environmental Engineering Middle East Technical UniversityAnkara 06800Turkey

The draft Integrated Pollution Prevention and Control(IPPC)regulation mandates compliance with best available techniques(BATs)for textile manufacturers.A study in Turkish textile facilities,covering 56 units across four sub-sectors,assessed the status of 488 BATs through on-site visits and *** aim was to gauge the sector’s adherence to *** findings revealed that 37% of surveyed BATs were fully implemented,rising to 88% when considering potential future *** suggests a strong industry inclination toward adopting BATs for cleaner production and *** study highlighted significant BAT-related investments in the textile sector,driven by environmental concerns,regulations,customer demands,resource efficiency,competition,and cost-benefit ***,the study results also indicated that there is still much work to do for the implementation of some *** was found that 60 BATs had lower implementation ratios(IR:0%-43%).Lower IR values for these BATs are mainly due to factors like specificity,high costs,long payback periods,operational difficulties,limited expertise,space constraints,customer requirements,quality concerns,operational issues,and sector-specific *** study recommends similar assessments in other European industrial sectors to evaluate compliance with mandatory BATs outlined in the Industrial Emissions *** insights from this study on the Turkish textile sector can serve as a valuable guide for future evaluations.

关键词： Best available techniques(BAT) Cleaner production Green Deal Integrated Pollution Prevention and Control(IPPC) Textile sector

Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi Farzad Dastaviz Mehdi Sheikh Arabi Ayyoob Khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

Performance improvement in stepped solar still modified by sponge layer

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Journal of Central South University 2024年第6期31卷 1973-1982页

作者： Mahtab TARAHOMI Saman RASHIDI Faramarz HORMOZI Shahabeddin ASHTIANI department of Chemical Petroleumand Gas EngineeringSemnan UniversitySemnanIran department of Energy Faculty of New Sciences and TechnologiesSemnan UniversitySemnanIran

In this paper,the experimental investigation on the performance improvement of conventional stepped solar still is *** steps are covered by the porous material to improve the performance of the conventional device and increase the evaporation *** the parameters,including the temperature on the glass surface,the water temperature inside the evaporation zone,and the amount of water produced in both conventional and modified stepped solar stills are measured and *** efficiency of two devices and their exergy efficiency have been ***,the economic analysis of both devices has been done to check the economic feasibility of the modified *** amount of freshwater generated during one day was 2244.4 and 3076.2 mL/m^(2),respectively for the conventional and modified stepped solar *** a result,the amount of water produced in one day by modified stepped solar still is 35.5% more than the conventional ***,the costs for the conventional and modified stepped solar stills have been calculated as 0.0359 and 0.029$/(L·m^(-2)),respectively.

关键词： stepped solar still black sponge efficiency exergy economic analysis

Multi-agent policy transfer via task relationship modeling

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Science China(Information sciences) 2024年第8期67卷 102-114页

作者： Rongjun QIN Feng CHEN Tonghan WANG Lei YUAN Xiaoran WU Yipeng KANG Zongzhang ZHANG Chongjie ZHANG Yang YU National Key Laboratory for Novel Software Technology Nanjing University Polixir technologies School of Engineering and Applied sciences Harvard University department of Computer Science and Technology Tsinghua University Institute for Interdisciplinary Information sciences Tsinghua University

Team adaptation to new cooperative tasks is a hallmark of human intelligence, which has yet to be fully realized in learning agents. Previous studies on multi-agent transfer learning have accommodated teams of different sizes but heavily relied on the generalization ability of neural networks for adapting to unseen tasks. We posit that the relationship among tasks provides key information for policy *** utilize this relationship for efficient transfer by attempting to discover and exploit the knowledge among tasks from different teams, proposing to learn an effect-based task representation as a common latent space among tasks, and using it to build an alternatively fixed training scheme. Herein, we demonstrate that task representation can capture the relationship among teams and generalize to unseen tasks. Thus, the proposed method helps transfer the learned cooperation knowledge to new tasks after training on a few source ***, the learned transferred policies help solve tasks that are difficult to learn from scratch.

关键词： multi-agent reinforcement learning cooperative transfer learning task relationship modeling multi-agent policy reuse multi-agent multi-task learning