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Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients

World Journal of Gastroenterology 2015年第34期21卷 9957-9965页

作者： Rui Huang Chen-Chen Yang Yong Liu Juan Xia Ran Su Ya-Li Xiong Gui-Yang Wang Zhen-Hua Sun Xiao-Min Yan Shan Lu Chao Wu department of Infectious Diseases Nanjing Drum Tower HospitalNanjing University Medical School department of Infectious Diseases Qidong People’s Hospital department of Laboratory Medicine Nanjing Drum Tower HospitalNanjing University Medical School department of Medicine University of Massachusetts Medical School

AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) ***:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral-treatment na?ve(n = 215) attending the Hepatitis Clinic at Nanjing drum tower hospital between August 2010 and December 2013. Healthy individuals without liver disease(n = 83) were included as controls. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the Liver:immune tolerance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of complete response(CR) based on serum GGT was also examined in EPH patients(n = 33) treated for 48 wk with nucleos(t)ide analogue(NA) therapy,including lamivudine plus adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA level < 500 copies/m L and HBe Ag seroconversion by 48 wk of treatment. RESULTS:Serum GGT levels were significantly increased in EPH and ENH patients relative to the IT,IC,and healthy control groups(P < 0.01 for all). However,no significant difference in serum GGT levels was found between the EPH and ENH groups. Baseline serum GGT levels were significantly higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decline in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectively). The receiver operating characteristic curve yielded a sensitivity of 85.71% and a specificity of 61.54% at a threshold value of 0.89 times the upper limit of normal for baseline serum GGT in the prediction of CR following NA therapy. CONCLUS

关键词： Gamma-glutamyl transferase Hepatitis B e antigen H

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miR-27b inhibits gastric cancer metastasis by targeting NR2F2

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Protein & Cell 2017年第2期8卷 114-122页

作者： Qingzhao Feng Xionglin Wu Fuchao Li Beibei Ning Xiaofeng Lu Yin Zhang Ying Pan Wenxian Guan department of General Surgery The Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing 210008 China department of Gerontology The Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing 210008 China department of Orthopaedics The Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing 210008 China The Children's hospital of Zhejiang University School of Medicine Hangzhou 310003 China department of Emergency The Yiwu Affiliated Hospital of Wenzhou Medical University Yiwu 322000 China

Increasing attention is focused on the down-regulation of miRNAs in cancer process. Nuclear receptor subfamily 2 （NR2F2, also known as COUP-TFU） is involved in the development of many types of cancers, but its role in gastric cancer remains elusive. In this experiment, oncomine and Kaplan-meier database revealed that NR2F2 was up-regulated in gastric cancer and that the high NR2F2 expression contributed to poor survival. MicroRNA-2Tb was targeted and down-regulated by NR2F2 in human gastric cancer tissues and cells. The ectopic expression of miR-27b inhibited gastric cancer cell proliferation and tumor growth in vitro and in vivo. Assays suggested that the overexpression of miR-27b could promote MGC-803 cells＇ migration and invasion and retard their metastasis to the liver. In addition, down-regulation of miR-27b enhanced GES-1 cells＇ proliferation and metastasis in vitro. These findings reveal that miR-27b is a tumor suppressor in gastric cancer and a biomarker for improving patients＇ survival.

关键词： miR-27b NR2F2 gastric cancer tumor metastasis

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CD4^(+)CD25^(+)but not CD4^(+)Foxp3^(+) T cells as a regulatory subset in primary biliary cirrhosis

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Cellular & Molecular Immunology 2010年第6期7卷 485-490页

作者： Dandan Wang Huayong Zhang Jun Liang Zhifeng Gu Qiang Zhou Xiangshan Fan Yayi Hou Lingyun Sun department of Immunology and Rheumatology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingChina department of Pathology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingChina Immunology Laboratory Nanjing University Medical SchoolNanjingJiangsuChina

Increasing evidence indicates a role for regulatory T cells(Tregs)in the immune response and in autoimmune diseases,but the role of Tregs and cytokines in autoimmune hepatic diseases remains largely unclear and controversial,especially in patients with primary biliary cirrhosis(PBC).This study was undertaken to investigate Tregs and different cytokines in the liver and peripheral blood of PBC *** found that these patients demonstrated a reduction of CD4^(+)CD25^(+) T cells but elevated CD4^(+)Foxp3^(+) T cells in peripheral blood mononuclear cells(PBMCs)and CD41 T *** percentage of CD4^(+)CD25^(+) T cells in PBMCs was negatively correlated with elevated plasma interferon(IFN)-c levels.A liver-specific analysis showed that the frequency of Foxp31 Tregs,transforming growth factor(TGF)-b1 and IFN-c were increased in PBC *** findings suggest that an imbalance between CD4^(+)CD25^(+) Tregs and cytotoxic cytokines plays a crucial role in the pathogenesis of PBC while the role of Foxp3 needs further investigation.

关键词： cytokines forkhead box P3 primary biliary cirrhosis regulatory T cells

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Major complications after radiofrequency ablation for liver tumors:Analysis of 255 patients

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World Journal of Gastroenterology 2009年第21期15卷 2651-2656页

作者： Wen-Tao Kong Wei-Wei Zhang Yu-Dong Qiu Tie Zhou Jun-Lan Qiu Wei Zhang Yi-Tao Ding department of Hepatobiliary Surgery Drum Tower Hospital Medical College of Nanjing University Nanjing 210008 Jiangsu Province China

AIM:To investigate the major complications after radiofrequency ablation(RFA) for the treatment of liver tumors and analyze possible risk factors that precipitate these ***:From March 2001 to April 2008,255 patients with liver tumors(205 male,50 female;age range,18-89 years;mean age,56.0 years) who received RFA were enrolled in this *** these patients,212 had hepatocellular carcinoma,39 had metastatic liver tumors and four had cholangiocellular *** hundred and forty eight patients had a single tumor,and 107 had multiple *** diameter of the tumors ranged 1.3-20 cm(mean,5.1 cm).All patients were treated with a cooled-tip perfusion electrode attached to a radiofrequency generator(Radionics,Burlington,MA,USA).RFA was performed via the percutaneous approach(n = 257),laparoscopy(n = 7),or open surgical treatment(n = 86).The major complications related to RFA were *** resultant data were analyzed to determine risk factors associated these ***:Among the 255 patients,425 liver tumors were treated and 350 RFA sessions were ***-seven(10%) major complications were observed which included 13 cases of liver failure,10 cases of hydrothorax requiring drainage,three casesof tumor seeding,one case of upper gastrointestinal bleeding,one case ofintrahepatic abscess,one case of bile duct injury,one case of cardiac arrest,and five cases of *** patients had more than two *** failure was the most severe complication and was associated with the highest *** patients died due to worsening liver ***-Pugh classification(P = 0.001) and choice of approach(P = 0.045) were related to post-treatment liver failure,whereas patient age,tumor size and number were not significant factors precipitating this ***:RFA can be accepted as a relatively safe procedure for the treatment of liver ***,attention should be paid to possible com

关键词： Complication Hepatocellular carcinoma Metastatic liver tumor Radiofrequency ablation Liverfailure

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Novel CDH1 germline mutations identified in Chinese gastric cancer patients

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World Journal of Gastroenterology 2013年第6期19卷 909-916页

作者： Qin-Hua Chen Wei Deng Xiao-Wei Li Xiu-Fang Liu Jing-Mei Wang Li-Feng Wang Nong Xiao Qiong He Ya-Ping Wang Yi-Mei Fan department of Medical Genetics Medical SchoolNanjing University Jiangsu Key Laboratory of Molecular Medicine department of Pathology Drum Tower Hospital Affiliated to Medical SchoolNanjing University department of Oncology Drum Tower Hospital Affiliated to Medical SchoolNanjing University Lujiang hospital

AIM:To give a comprehensive report of E-cadheringene (CDH1) variations in a population at a high risk for gastric cancer (GC).METHODS:The samples consisted of 178 men and 58 women with a mean age of 62.3 ± 9.4 years and an age range of 30-84 years.A total of 240 cancerfree controls were recruited (mean age of 61.8 ± 10.1 years,age range of 26-82 years).Samples were screened for CDH1 germline mutations by high-resolution melting analysis or directly *** reporter assay,RNA splicing assay and bioinformatic analysis were used to evaluate the effect of ***:Four novel CDH1 sequence alterations were identified in GC patients including a G>T transition 49 bp before the start codon;a three-nucleotide deletion,c.44_46del TGC;one missense mutation,c.604G>A (V202I);and one variation in the intron,c.1320+7A>*** addition,polymorphism frequencies were observed for CDH1-164delT,-161C>A,-73A>C,c.48+6C>T,c.48+62_48+63delinsCGTGCCCCAGCCC,c.894C>T (A298A),c.1224G>A (A408A),c.1888C>G (L630V),c.2076T>C (A692A),and c.2253C>T (N751N) which is similar to the data reported in http://***/projects/SNP/.RNA splicing analysis suggested that the c.1320+7A>G and c.1224G>A variations did not affect exon splicing *** reporter assay demonstrated that the c.-49T variation might be helpful for E-cadherin transcription,though the increase in transcription activity is limited (only 33%).SIFT score and PolyPhen analysis both demonstrated that the L630V missense mutation probably damages protein function,while the V202I variant does ***:This study reveals novel mutations in sporadic GC patients which had been poorly investigated for susceptibility genes.

关键词： Gastric cancer Germline mutation CDH1 Luciferase reporter assay RNA splicing analysis

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Rare cause of appendicitis:Mechanical obstruction due to Fasciolopsis buski infestation

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World Journal of Gastroenterology 2015年第10期21卷 3146-3149页

作者： You-Hong Cao Yi-Min Ma Feng Qiu Xiao-Qi Zhang department of Gastroenterology Nanjing Gaochun People’s Hospital department of Gastroenterology the Drum Tower Hospital Affiliated to Nanjing University

This study aimed to improve the understanding of the clinical characteristics of patients with fasciolopsiasis and thus reduce misdiagnosis and inappropriate *** retrospectively analyzed the clinical data of two patients with fasciolopsiasis which caused *** buski infestation as a cause of appendicitis is very rarely seen in the *** clinical characteristics,clinical manifestations,diagnostic methods and the principles of treatment in these two patients were analyzed.

关键词： Fasciolopsis buski Appendicitis Fasciolopsiasis Mi

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Successful treatment of a patient with diffuse alveolar hemorrhage and anti-neutrophil cytoplasmic antibody-associated vasculitis

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World Journal of Emergency Medicine 2022年第3期13卷 245-247页

作者： Yao Liu Qiu-ling Zhang Heng-jun Liu Wei Wang Yi Zhou Peng Xu Emergency department of drum tower hospital the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Dear editor,Anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis(AAV)is a cluster of disorders characterized by inflammation and destruction of smalland medium-size blood vessels as well as the presence of... 详细信息

关键词： neutrophil inflammation ANCA

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Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 343-353页

作者： Li-Xiang Liu Hao Wang Bo Gao Ting-Ting Xu Qing-Gang Yuan Shi-Zhen Zhou Chao Ding Ji Miao Wen-Xian Guan department of General Surgery Nanjing Drum Tower HospitalNanjing Drum Tower Hospital Clinical CollegeNanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina department of General Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina department of Clinical Nutrition Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina department of General Surgery Nanjing Drum Tower Clinical College of Xuzhou Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND The controlling nutritional status(CONUT)score effectively reflects a patient’s nutritional status,which is closely related to cancer *** study invest-igated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer,and compared the predictive ability of the CONUT score with other *** To analyze the predictive performance of the CONUT score for the survival rate of colorectal cancer patients who underwent potentially curative *** This retrospective analysis included 217 patients with newly diagnosed *** CONUT score was calculated based on the serum albumin level,total lymphocyte count,and total cholesterol *** cutoff value of the CONUT score for predicting prognosis was 4 according to the Youden Index by the receiver operating characteristic *** associations between the CONUT score and the prognosis were performed using Kaplan-Meier curves and Cox regression *** Using the cutoff value of the CONUT score,patients were stratified into CONUT low(n=189)and CONUT high groups(n=28).The CONUT high group had worse overall survival(OS)(P=0.013)and relapse-free survival(RFS)(P=0.015).The predictive performance of CONUT was superior to the modified Glasgow prognostic score,the prognostic nutritional index,and the neutrophil-to-lymphocyte ***,the predictive performances of CONUT+tumor node metastasis(TNM)stage for 3-year OS[area under the receiver operating characteristics curve(AUC)=0.803]and 3-year RFS(AUC=0.752)were no less than skeletal muscle mass index(SMI)+TNM *** CONUT score was negatively correlated with SMI(P<0.01).CONCLUSION As a nutritional indicator,the CONUT score could predict long-term outcomes after radical surgery for colorectal cancer,and its predictive ability was superior to other *** correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.

关键词： Controlling nutritional status Colorectal cancer Prognostic marker Sarcopenia Skeletal muscle

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FOXO1 Alleviates Liver Ischemia-reperfusion Injury by Regulating the Th17/Treg Ratio through the AKT/Stat3/FOXO1 Pathway

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1138-1147页

作者： Hao-Zhen Ren Sen-Zhe Xia Xue-Qian Qin An-Yin Hu Jing-Lin Wang department of Hepatobiliary Surgery Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJi-angsuChina department of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Jiangsu UniversityNanjingJiangsuChina department of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsuChina

Background and Aims:Hepatic ischemic reperfusion in-jury(IRI)occurring during surgery seriously affects patient *** specific mechanism of IRI has not been fully *** study aim was to explore the changes of in-flammatory environment,and the relationship of the Th17/Treg cell ratio and FOXO1 expression in hepatic ***:Liver samples at different ischemic times were collected from patients and *** expression of inflammatory markers and FOXO1 in the liver was detected by western blotting and *** changes of liver lymphocytes were analyzed by flow *** AKT/Stat3/FOXO1 pathway was veri-fied by targeting AKT with *** role of FOXO1 in liver inflammation and changes in lymphocyte phenotype was confirmed by upregulating FOXO1 with ***-sults:Prolonged ischemic time aggravates liver injury in both humans and mouse models of hepatic ***-stress caused Th17/Treg imbalance and FOXO1 down-regulation by activat-ing the AKT/Stat3/FOXO1 signaling *** of FOXO1 reversed the Th17/Treg cytokine imbalance and altered the inflammation environment in the ***:Liver IRI induced Th17/Treg *** of FOXO1 re-versed the imbalance and alleviated liver inflammation.

关键词： Liver ischemia-reperfusion injury Inflammatory factors Th17 Treg AKT/Stat3/FOXO1 pathway

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Comparison of Effects of Liuzijue Exercise and Conventional Respiratory Training on Patients after Cardiac Surgery:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第7期29卷 579-589页

作者： ZHANG Qiao-li GE Min CHEN Cheng FAN Fu-dong JIN Yan ZHANG Ning WANG Lei department of Rehabilitation Medicine Nanjing Drum Tower HospitalClinical College of Nanjing University of Chinese MedicineNanjing 210008China department of Rehabilitation College of Acupuncture and Moxibustion and Massage Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China department of Cardio-Thoracic Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China department of Ultrasound Nanjing Drum Tower Hospitalthe Affi liated Hospital of Nanjing University Medical SchoolNanjing 210008China

Objective To evaluate the feasibility and safety of Liuzijue exercise(LE)for the clinical effect in patients after cardiac *** Totally 120 patients who underwent cardiac surgery and were admitted to the Cardiothoracic Intensive Care Unit of Nanjing drum tower hospital between July and Oclober,2022 were allocated to the LE group,the conventional respiratory training(CRT)group,and the control group by a random number table at a ratio of 1:1:1;40 patients in each *** patients received routine treatment and cardiac *** group and CRT group respectively performed LE and CRT once a day for 30 min for 7 *** group did not receive specialized respiratory *** forced vital capacity,forced expiratory volume in 1 s,peak inspiratory flow rate,peak expiratory flow rate,maximum inspiratory pressure,maximum expiratory pressure,modified Barthel index(MBI),and Hamilton Rating Scale for Anxiety(HAM-A)were evaluated before,after 3 and 7 days of *** addition,the postoperative length of hospital stay(LOS)and the adverse events that occurred during the intervention period were *** A total of 107 patients completed the study,120 patients were included in the *** 3 days of intervention,the pulmonary function,respiratory muscle strength,MBI and HAM-A of all 3 groups improved compared with that before the intervention(P<0.05 or P<0.01).Compared with the control group,pulmonary function and respiratory muscle strength were significantly improved in the CRT and LE groups(P<0.05 or P<0.01).MBI and HAM-A were significantly improved in the LE group compared with the control and CRT groups(P<0.05 or P<0.01).On the 7th day after intervention,the difference was still statistically significant(P<0.01),and was significantly different from that on the 3rd day(P<0.05 or P<0.01).In addition,on the 7th day of intervention,the pulmonary function and respiratory muscle strength in the LE group were significantly improved comp

关键词： Liuzijue exercise pulmonary function Liuzijue exercise pulmonary function respiratory muscle strength activities of daily living respiratory muscle strength activities of daily living anxiety cardiac surgery

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