Major complications after radiofrequency ablation for liver tumors:Analysis of 255 patients
Major complications after radiofrequency ablation for liver tumors:Analysis of 255 patients作者机构：Department of Hepatobiliary Surgery Drum Tower Hospital Medical College of Nanjing University Nanjing 210008 Jiangsu Province China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2009年第15卷第21期
页 面：2651-2656页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Complication Hepatocellular carcinoma Metastatic liver tumor Radiofrequency ablation Liverfailure
摘 要：AIM:To investigate the major complications after radiofrequency ablation(RFA) for the treatment of liver tumors and analyze possible risk factors that precipitate these ***:From March 2001 to April 2008,255 patients with liver tumors(205 male,50 female;age range,18-89 years;mean age,56.0 years) who received RFA were enrolled in this *** these patients,212 had hepatocellular carcinoma,39 had metastatic liver tumors and four had cholangiocellular *** hundred and forty eight patients had a single tumor,and 107 had multiple *** diameter of the tumors ranged 1.3-20 cm(mean,5.1 cm).All patients were treated with a cooled-tip perfusion electrode attached to a radiofrequency generator(Radionics,Burlington,MA,USA).RFA was performed via the percutaneous approach(n = 257),laparoscopy(n = 7),or open surgical treatment(n = 86).The major complications related to RFA were *** resultant data were analyzed to determine risk factors associated these ***:Among the 255 patients,425 liver tumors were treated and 350 RFA sessions were ***-seven(10%) major complications were observed which included 13 cases of liver failure,10 cases of hydrothorax requiring drainage,three casesof tumor seeding,one case of upper gastrointestinal bleeding,one case ofintrahepatic abscess,one case of bile duct injury,one case of cardiac arrest,and five cases of *** patients had more than two *** failure was the most severe complication and was associated with the highest *** patients died due to worsening liver ***-Pugh classification(P = 0.001) and choice of approach(P = 0.045) were related to post-treatment liver failure,whereas patient age,tumor size and number were not significant factors precipitating this ***:RFA can be accepted as a relatively safe procedure for the treatment of liver ***,attention should be paid to possible com
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