miR-27b inhibits gastric cancer metastasis by targeting NR2F2
miR-27b inhibits gastric cancer metastasis by targeting NR2F2作者机构：Department of General Surgery The Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing 210008 China Department of Gerontology The Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing 210008 China Department of Orthopaedics The Affiliated Drum Tower Hospital of Medical School of Nanjing University Nanjing 210008 China The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003 China Department of Emergency The Yiwu Affiliated Hospital of Wenzhou Medical University Yiwu 322000 China
出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)
年 卷 期：2017年第8卷第2期
页 面：114-122页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：supported by the Fundamental Research Funds for the Central Universities
主 题：miR-27b NR2F2 gastric cancer tumor metastasis
摘 要：Increasing attention is focused on the down-regulation of miRNAs in cancer process. Nuclear receptor subfamily 2 （NR2F2, also known as COUP-TFU） is involved in the development of many types of cancers, but its role in gastric cancer remains elusive. In this experiment, oncomine and Kaplan-meier database revealed that NR2F2 was up-regulated in gastric cancer and that the high NR2F2 expression contributed to poor survival. MicroRNA-2Tb was targeted and down-regulated by NR2F2 in human gastric cancer tissues and cells. The ectopic expression of miR-27b inhibited gastric cancer cell proliferation and tumor growth in vitro and in vivo. Assays suggested that the overexpression of miR-27b could promote MGC-803 cells＇ migration and invasion and retard their metastasis to the liver. In addition, down-regulation of miR-27b enhanced GES-1 cells＇ proliferation and metastasis in vitro. These findings reveal that miR-27b is a tumor suppressor in gastric cancer and a biomarker for improving patients＇ survival.
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