检索结果-南通市图书馆

Biofluid Biomarkers of Alzheimer's Disease:Progress,Problems,and Perspectives

在线全文

学校读者我要写书评

暂无评论

neuroscience Bulletin 2022年第6期38卷 677-691页

作者： Shan Huang Yan-Jiang Wang Junhong Guo department of neurology First HospitalShanxi Medical UniversityTaiyuan 030000China Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing 400042China

Since the establishment of the biomarker-based A-T-N(Amyloid/Tau/Neurodegeneration)framework in Alzheimer's disease(AD),the diagnosis of AD has become more precise,and cerebrospinal fluid tests and positron emission tomography examinations based on this framework have become widely accepted.However,the A-T-N framework does not encompass the whole spectrum of AD pathologies,and problems with invasiveness and high cost limit the application of the above diagnostic methods aimed at the central nervous system.Therefore,we suggest the addition of an“X”to the A-T-N framework and a focus on peripheral biomarkers in the diagnosis of AD.In this review,we retrospectively describe the recent progress in biomarkers based on the A-T-N-X framework,analyze the problems,and present our perspectives on the diagnosis of AD.

关键词： Alzheimer's disease Biomarker Amyloidbeta Tau Diagnosis

The role of DJ-1 complexes and catecholamine metabolism： relevance for familial and idiopathic Parkinson＇s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第5期13卷 815-816页

作者： Dominik Piston Matthew E.Gegg German centre for Neurodegenerative Diseases (DZNE) Bonn Germany department of clinical neuroscience UCL Institute of Neurology London UK

Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.

关键词： The role of DJ-1 complexes and catecholamine metabolism relevance for familial and idiopathic Parkinson’s disease GBA DA

Could non-invasive brain-stimulation prevent neuronal degeneration upon ion channel re-distribution and ion accumulation after demyelination?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第11期15卷 1977-1980页

作者： Friederike Pfeiffer Alia Benali Werner Reichardt centre for Integrative neuroscience(CIN) University of TubingenTubingenGermany Section for Computational Sensomotorics Department of Cognitive NeurologyHertie-Institute for Clinical Brain Research and Centre for Integrative NeuroscienceUniversity of TubingenTubingenGermany

Fast and efficient transmission of electrical signals in the nervous system is mediated through myelinated nerve fibers.In neuronal diseases such as multiple sclerosis,the conduction properties of axons are disturbed by the removal of the myelin sheath,leaving nerve cells at a higher risk of degenerating.In some cases,the protective myelin sheath of axons can be rebuilt by remyelination through oligodendroglial cells.In any case,however,changes in the ion channel organization occur and may help to restore impulse conduction after demyelination.On the other hand,changes in ion channel distribution may increase the energy demand of axons,thereby increasing the probability of axonal degeneration.Many attempts have been made or discussed in recent years to increase remyelination of affected axons in demyelinating diseases such as multiple sclerosis.These approaches range from pharmacological treatments that reduce inflammatory processes or block ion channels to the modulation of neuronal activity through electrical cortical stimulation.However,these treatments either affect the entire organism(pharmacological)or exert a very local effect(electrodes).Current results show that neuronal activity is a strong regulator of oligodendroglial development.To bridge the gap between global and very local treatments,non-invasive transcranial magnetic stimulation could be considered.Transcranial magnetic stimulation is externally applied to brain areas and experiments with repetitive transcranial magnetic stimulation show that the neuronal activity can be modulated depending on the stimulation parameters in both humans and animals.In this review,we discuss the possibilities of influencing ion channel distribution and increasing neuronal activity by transcranial magnetic stimulation as well as the effect of this modulation on oligodendroglial cells and their capacity to remyelinate previously demyelinated axons.Although the physiological mechanisms underlying the effects of transcranial magnetic stimulation clearly need further inv

关键词： ion channel multiple sclerosis neuronal activity oligodendrocyte (re-)myelination repetitive transcranial magnetic stimulation transcranial magnetic stimulation

A superficial siderosis-related transient focal neurological episode in a patient with Marfan syndrome

在线全文

学校读者我要写书评

暂无评论

慢性疾病与转化医学:英文版 2023年第3期9卷 269-272页

作者： Slaven Pikija Eugen Trinka Pfaff Johannes Andreea Toma Mahdi Safdarian department of neurology Neurocritical Care and NeurorehabilitationCentre of Cognitive NeuroscienceChristian Doppler University HospitalParacelsus Medical UniversitySalzburgMember of EpiCARESalzburgAustria department of neurology Christian Doppler University HospitalCentre of Cognitive NeuroscienceNeuroscience InstituteParacelsus Medical UniversitySalzburgAustria Karl Landsteiner Institute for Neurorehabilitation and Space neurology SalzburgAustria department of Neuroradiology Christian Doppler University HospitalCentre of Cognitive NeuroscienceNeuroradiology InstituteParacelsus Medical UniversitySalzburgAustria

To the Editor,Marfan syndrome is an autosomal dominant disorder of connective tissue caused by mutations in the gene encoding a matrix component of microfibrils;fibrillin-1(FBN1),with an incidence of about 1-3 per 10,000 individuals.2.3 Cardinal manifestations include proximal aortic aneurysm,dislocation of the ocular lens,and long-bone overgrowth.Dural ectasia,which is defined as a ballooning or significant widening of the dural sac or neural root sleeves,is also a common finding in these patients,which is reported to present in more than 60%of cases and is considered a major criterion for the clinical diagnosis of this syndrome.

关键词： superficial Marfan balloon

Why do‘OFF’periods still occur during continuous drug delivery in Parkinson’s disease?

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2022年第1期11卷 280-293页

作者： Silvia Rota Daniele Urso Daniel J.van Wamelen Valentina Leta Iro Boura Per Odin Alberto J.Espay Peter Jenner K.Ray Chaudhuri department of Basic and clinical neurosciences Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondonUK Parkinson’s Foundation centre of Excellence King’s College HospitalLondonUK department of Neuroimaging Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondonUK centre for Neurodegenerative Diseases and the Aging Brain Department of Clinical Research in NeurologyUniversity of Bari‘Aldo Moro“Pia Fondazione Cardinale G.Panico”73039 TricaseItaly Donders Institute for Brain Cognition and BehaviourDepartment of NeurologyRadboud University Medical CentreNijmegenThe Netherlands School of Medicine University of CreteCreteGreece department of neurology University Hospital of HeraklionCreteGreece Division of neurology Department of Clinical Sciences LundLund UniversityLundSweden University of Cincinnati Gardner neuroscience Institute Gardner Family Center for Parkinson’s Disease and Movement DisordersDepartment of NeurologyUniversity of CincinnatiCincinnatiOHUSA Institute of Pharmaceutical Sciences Faculty of Life Science and MedicineKing’s College LondonLondonUK.

Continuous drug delivery(CDD)is used in moderately advanced and late-stage Parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations,while subcutaneous apomorphine infusion and levodopa-carbidopa intestinal gel are utilised in advanced PD.All three strategies are considered examples of continuous dopaminergic stimulation achieved through CDD.A central premise of the CDD is to achieve stable control of the parkinsonian motor and non-motor states and avoid emergence of‘OFF’periods.However,data suggest that despite their efficacy in reducing the number and duration of‘OFF’periods,these strategies still do not prevent‘OFF’periods in the middle to late stages of PD,thus contradicting the widely held concepts of continuous drug delivery and continuous dopaminergic stimulation.Why these emergent‘OFF’periods still occur is unknown.In this review,we analyse the potential reasons for their persistence.The contribution of drug-and device-related involvement,and the problems related to site-specific drug delivery are analysed.We propose that changes in dopaminergic and non-dopaminergic mechanisms in the basal ganglia might render these persistent‘OFF’periods unresponsive to dopaminergic therapy delivered via CDD.

关键词： ‘OFF’periods Continuous drug delivery Continuous dopaminergic stimulation Rotigotine patch Subcutaneous apomorphine infusion Levodopa-carbidopa intestinal gel

Regulation of neuroinflammatory properties of glial cells by T cell effector molecules

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第2期13卷 234-236页

作者： chittappen k.prajeeth jochen huehn martin stangel clinical neuroimmunology and neurochemistry department of neurologyhannover medical schoolHannoverGermany experimental immunology helmholtz centre for infection researchBraunschweigGermany center of systems neuroscience hannover medical schoolGermany

Multiple sclerosis （MS） is a chronic inflammatory and neurodegenerative disorder that is thought to be mediated by autoreactive T lymphocytes that find their way into the central nervous system （CNS）. The pathological mechanism of MS is still being elucidated but it involves complex interactions between infiltrating immune cells and resi- dent glial cells within the CNS that culminate into strong neuroinflammation and axonal damage.

关键词： Regulation of neuroinflammatory properties of glial cells by T cell effector molecules Th CNS

Safety and biodegradability of a synthetic dural sealant patch(Liqoseal)in a porcine cranial model

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2021年第4期4卷 398-405页

作者： Ahmet Kinaci Wilhelmina Bergmann Sander van Thoor Saskia Redegeld Albert van der Zwan Tristan P.C.van Doormaal department of neurology and Neurosurgery Brain CenterUniversity Medical Centre UtrechtUtrechtThe Netherlands Brain Technology Institute UtrechtThe Netherlands Division of Pathology Faculty of Veterinary MedicineUtrecht UniversityUtrechtThe Netherlands department of Neurosurgery Clinical Neuroscience CenterUniversity Hospital ZurichZurichSwitzerland

Background:Liqoseal consists of a watertight layer of poly(ester)ether urethane and an adhesive layer containing polyethylene glycol-N-hydroxysuccinimide(PEG-NHS).It is designed to prevent cerebrospinal fluid(CSF)leakage after intradural surgery.This study assessed the safety and biodegradability of Liqoseal in a porcine craniotomy model.Methods:In 32 pigs a craniotomy plus durotomy was performed.In 15 pigs Liqoseal was implanted,in 11 control pigs no sealant was implanted and in 6 control pigs a control dural sealant(Duraseal or Tachosil)was implanted.The safety of Liqoseal was evaluated by clinical,MRI and histological assessment.The degradation of Liqoseal was histologically estimated.Results:Liqoseal,2 mm thick before application,did not swell and significantly was at maximum mean thickness of 2.14(±0.37)mm at one month.The foreign body reaction induced by Liqoseal,Duraseal and Tachosil were comparable.Liqoseal showed no adherence to the arachnoid layer and was completely resorbed between 6 and 12 months postoperatively.In one animal with Liqoseal,an epidural fluid collection containing CSF could not be excluded.Conclusion:Liqoseal seems to be safe for intracranial use and is biodegradable.The safety and performance in humans needs to be further assessed in clinical trials.

关键词： cerebrospinal fluid leakage craniotomy dura in vivo model sealant

Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort

在线全文

学校读者我要写书评

暂无评论

neuroscience Bulletin 2020年第7期36卷 696-704页

作者： Wei-Wei Li Zhen Wang Dong-Yu Fan Ying-Ying Shen Dong-Wan Chen Hui-Yun Li Ling Li Heng Yang Yu-Hui Liu Xian-Le Bu Wang-Sheng Jin Fan Zeng Zhi-Qiang Xu Jin-Tai Yu Li-Yong Chen Yan-Jiang Wang Department of Neurology and Centre for Clinical Neuroscience Duping HospitalThird Military Medical UniversityChongqing 400042China department of Anaesthesiology Daping HospitalThird Military Medical UniversityChongqing 400042China Chongqing Key Laboratory of Aging and Diseases Chongqing 400042China centre for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China department of neurology Huashan HospitalFudan UniversityShanghai 200040China

To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer’s disease(sAD)and pathological biomarkers in cerebrospinal fluid(CSF),462 sAD patients and 463 age-matched cognitively normal(CN)controls were genotyped for 35 singlenucleotide polymorphisms(SNPs)that are significantly associated with sAD.Then,the alleles found to be associated with sAD were used to build polygenic risk score(PRS)models to represent the genetic risk.Receiver operating characteristic(ROC)analyses and the Cox proportional hazards model were used to evaluate the predictive value of PRS for the sAD risk and age at onset.We measured the CSF levels of Aβ42,Aβ42/Aβ40,total tau(T-tau),and phosphorylated tau(P-tau)in a subgroup(60 sAD and 200 CN participants),and analyzed their relationships with the PRSs.We found that 14 SNPs,including SNPs in the APOE,BIN1,CD33,EPHA1,SORL1,and TOMM40 genes,were associated with sAD risk in our cohort.The PRS models built with these SNPs showed potential for discriminating sAD patients from CN controls,and were able to predict the incidence rate of sAD and age at onset.Furthermore,the PRSs were correlated with the CSF levels of Aβ42,Aβ42/Aβ40,T-tau,and P-tau.Our study suggests that PRS models hold promise for assessing the genetic risk and development of AD.As genetic risk profiles vary among populations,large-scale genome-wide sequencing studies are urgently needed to identify the genetic risk loci of sAD in Chinese populations to build accurate PRS models for clinical practice.

关键词： Alzheimer's disease Single nucleotide polymorphism Polygenic risk score Cerebrospinal fluid Biomarker Amyloid-beta Tau

Biological mechanisms and possible primary prevention of depression

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2022年第5期12卷 770-772页

作者： Chih-Yun Kuo Ivo Stachiv department of neurology and centre of clinical neuroscience First Faculty of MedicineCharles UniversityPrague 12108Czech Republic department of Functional Materials Institute of PhysicsCzech Academy of SciencesPraha 18021Czech Republic

Individuals with unipolar depressive disorder(UDD)are having an increased risk of death and development of dementia in later life.It is widely expected that in a near future UDD would be the leading cause of death;therefore,a primary inexpensive prevention of UDD will be of a great importance to the society.Several studies provide evidences supporting the positive effect of Mediterranean diet on a reduced risk for development of depression.

关键词： Unipolar depressive disorder Mediterranean diet Depression Primary prevention Dementia