The role of DJ-1 complexes and catecholamine metabolism： relevance for familial and idiopathic Parkinson＇s disease

作     者：Dominik Piston Matthew E.Gegg 

作者机构：German Centre for Neurodegenerative Diseases (DZNE) Bonn Germany Department of Clinical Neuroscience UCL Institute of Neurology London UK 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第5期

页      面：815-816页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：funded by a Medical Research Council(UK)Experimental Medicine grant[MR/M006646/1] 

主　　题：The role of DJ-1 complexes and catecholamine metabolism relevance for familial and idiopathic Parkinson’s disease GBA DA 

摘      要：Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.