检索结果-南通市图书馆

Therapeutic actions of terpenes in neurodegenerative disorders and their correlations with the regulation and remodeling of the extracellular matrix

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2025年第1期49卷 109-125页

作者： RENATA DA SILVA CARNEIRO MATEUS HENRIQUE DE ALMEIDA DA COSTA JOSÉZILTON LIMA VERDE SANTOS VALDILÉIA TEIXEIRA UCHÔA LUCIANO DA SILVA LOPES ANDERSON NOGUEIRA MENDES Laboratory of Science in Innovation and Technology-LACITEC Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil Laboratory of Natural Products and Bioprospecting Natural Sciences CenterState University of PiauíTeresina64018Brazil Laboratory of Experimental neurochemistry Research-LAPNEX Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil

Neurodegenerative diseases are a major public health challenge,mainly affecting the elderly population and compromising their cognitive,sensory,and motor ***,available therapies focus on alleviating symptoms and slowing the progression of these conditions,but they do not yet offer a definitive *** this scenario,terpenes emerge as promising natural alternatives due to their neuroprotective *** compounds can reduce the formation of protein aggregates,neutralize free radicals,and inhibit pro-inflammatory enzymes,which are crucial factors in the development of neurodegenerative *** addition,terpenes also play an important role in the regulation and remodeling of the extracellular matrix,a key target for improving neuronal *** such as linalool,pinene,and eugenol,among others,have potential therapeutic effects by modulating inflammatory and oxidative stress processes,the main factors that contribute to the progression of these *** suggest that these compounds act on signaling pathways that regulate the extracellular matrix,improving neuronal integrity and,consequently,cognitive and motor *** work aims to review the potential of terpenes in the treatment of neurodegenerative disorders,with emphasis on their ability to regulate oxidative stress and inflammation,as well as to remodel the extracellular *** interaction between these mechanisms points to the promising use of terpenes as an innovative and natural therapeutic approach to combat these diseases.

关键词： Terpenes Neurodegenerative Disorders Extracellular matrix

The role of NADPH oxidase （NOX） enzymes in neurodegenerative disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers in Biology 2013年第2期8卷 175-188页

作者： Abiodun AJAYI Xin YU Anna-Lena STROM department of neurochemistry Stockholm University 10691 Stockholm Sweden

Recently, mounting evidence implicating reactive oxygen species （ROS） generated by NADPH oxidase （NOX） enzymes in the pathogenesis of several nenrodegenerative diseases including Amyotrophic lateral sclerosis （ALS）, Alzheimer＇s （AD）, Parkinson＇s （PD） and polyglntamine disease, have arisen. NOX enzymes are transmembrane proteins and generate reactive oxygen species by transporting electrons across lipid membranes. Under normal healthy conditions, low levels of ROS produced by NOX enzymes have been shown to play a role in neuronal differentiation and synaptic plasticity. However, in chronic nenrodegenerative diseases over-activation of NOX in neurons, as well as in astrocytes and microglia, has been linked to pathogenic processes such as oxidative stress, exitotoxicity and neuroinflammation. In this review, we summarize the current knowledge about NOX functions in the healthy central nervous system and especially the role of NOX enzymes in neurodegenerative disease processes.

关键词： neurodegeneration oxidative stress NADPH oxidase microglia inflammation

Dysfunctional glia:contributors to neurodegenerative disorders

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第2期16卷 218-222页

作者： Marta Sidoryk-Węgrzynowicz Lidia Strużyńska Laboratory of Pathoneurochemistry Department of NeurochemistryMossakowski Medical Research CentrePolish Academy of SciencesWarsawPoland

Astrocytes are integral components of the central nervous system,where they are involved in numerous functions critical for neuronal development and functioning,including maintenance of blood-brain barrier,formation of synapses,supporting neurons with nutrients and trophic factors,and protecting them from *** roles are markedly affected in the course of chronic neurodegenerative disorders,often before the onset of the *** this review,we summarize the recent findings supporting the hypothesis that astrocytes play a fundamental role in the processes contributing to *** focus onα-synucleinopathies and tauopathies as the most common neurodegenerative *** mechanisms implicated in the development and progression of these disorders appear not to be exclusively neuronal,but are often related to the astrocytic-neuronal integrity and the response of astrocytes to the altered microglial function.A profound understanding of the multifaceted functions of astrocytes and identification of their communication pathways with neurons and microglia in health and in the disease is of critical significance for the development of novel mechanism-based therapies against neurodegenerative disorders.

关键词： astrocytes microglia neurodegeneration neuroinflammation synaptic dysfunction synucleinopathies tauopathies

A novel viewpoint in glaucoma therapeutics: enriched environment

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第7期17卷 1431-1439页

作者： María F.González Fleitas Damián Dorfman Ruth E.Rosenstein Laboratory of Retinal neurochemistry and Experimental Ophthalmology Department of Human BiochemistrySchool of Medicine/CEFyBOUniversity of Buenos Aires/CONICETBuenos AiresArgentina

Glaucoma is one of the world’s most frequent visual impairment causes and leads to selective damage to retinal ganglion cells and their *** glaucoma’s most accepted risk factor is increased intraocular pressure(IOP),the mechanisms behind the disease have not been fully *** date,IOP lowering remains the gold standard;however,glaucoma patients may still lose vision regardless of effective IOP ***,the exclusive IOP control apparently is not enough to stop the disease progression,and developing new resources to protect the retina and optic nerve against glaucoma is a goal of vast clinical *** pharmacological treatments,environmental conditions have been shown to prevent neurodegeneration in the central nervous *** this review,we discuss current concepts on key pathogenic mechanisms involved in glaucoma,the effect of enriched environment on these mechanisms in different experimental models,as well as recent evidence supporting the preventive and therapeutic effect of enriched environment exposure against experimental glaucomatous ***,we postulate that stimulating vision may become a non-invasive and rehabilitative therapy that could be eventually translated to the human disease,preventing glaucoma-induced terrible sequelae resulting in permanent visual disability.

关键词： brain-derived neurotrophic factor chondroitin sulfate enriched environment glaucoma optic nerve axons optic nerve glia retinal ganglion cells visual stimulation

From brain function to therapy

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2014年第4期57卷 467-468页

作者： GONG ChengXin department of neurochemistry Inge Grundke-Iqbal Research Floor New York State Institute for Basic Research in Developmental Disabilities

During the 20th century, biological sciences developed enormously and uncovered many mysteries of life. With one exception, we have now understood very well the vari- ous systems of our body, such as the digestive, circulatory and reproductive systems. This one exception is the nervous system, mainly the brain. The scientific study of the nervous system, especially of the brain, has become the hottest field in all the biological sciences in the 21st century. This is ev- idenced by the launch of two giant 10-year, billion-dollar projects in 2013--the BRAIN （Brain Research through Advancing Innovative Neurotechnologies） Initiative in the United States, and the Human Brain Project funded by the European Union. China has also spent hundreds of millions RMB for brain projects in recent years.

关键词：脑功能治疗科学发展神经系统生物科学人类脑计划功能系统消化系统

Consequences of early life stress on the structure and function of the adult mouse retina

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第1期19卷 150-151页

作者： Juan S.Calanni Ruth E.Rosenstein Laboratory of Retinal neurochemistry and Experimental Ophthalmology Department of Human BiochemistrySchool of Medicine/CEFyBOUniversity of Buenos Aires/CONICETBuenos AiresArgentina

Early-life stress(ELS)refers to a period of environmental/social deprivation,physica l,sexual or emotional abuse,neglect,severe and/or chronic trauma in the prenatal/early postnatal stage,which is closely related to many adverse psychiatric disorders later in life,such as depressive disorder,substance abuse,dysthymia,panic,anxiety,and suicidal behavior in adulthood(Waters and Gould,2022).

关键词： stress life Gould

DSSylation, a novel guide for protein degradation？

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2014年第2期5卷 91-93页

作者： Cheng-Xin Gong department of neurochemistry Inge Grundke-lqbal Research Floor New York State Institute for Basic Research in Developmental Disabilities Staten Island NY 10314 USA

The natural design for the generation and the fate of proteins in an organism could be as complicated as life itself. A protein is biosynthesized strictly according to the message carried by the mRNA transcribed from its gene. However, when, where, what and how much a gene is expressed are regulated precisely and dynamically at multiple levels, including at transcription, mRNA maturation, alternative splicing, and translation levels. A newly synthesized protein often needs to be further modified and sorted posttransla- tionally for its optimal confirmation and function. When a protein reaches its life span, the senescent protein is degraded by protein degradation machinery involving the ubiquitin-proteosome system and lysosomes. Protein homeostasis is essential for maintaining the normal mor- phology and function of the cell.

关键词： protein degradation natural design biosynthesized strictly

Dynamic motility of microglia: Purinergic modulation of microglial movement in the normal and pathological brain

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2012年第1期7卷 44-49页

作者： KEIKO OHSAWA SHINICHI KOHSAKA department of neurochemistry National Institute of Neuroscience

小神经胶质细胞具有高分支且可以动态移动的细胞突起,在生理条件下监控脑的活动。在病理刺激下,小神经胶质细胞表现出形态学变化,向损伤部位迁移,并在此处的炎性反应和神经元损伤中发挥重要作用。在脑损伤发生的数分钟内,小神经胶质细... 详细信息

小神经胶质细胞具有高分支且可以动态移动的细胞突起,在生理条件下监控脑的活动。在病理刺激下,小神经胶质细胞表现出形态学变化,向损伤部位迁移,并在此处的炎性反应和神经元损伤中发挥重要作用。在脑损伤发生的数分钟内,小神经胶质细胞突起很快延伸至损伤部位。这种趋化作用为损伤部位的ATP释放和随之发生的小神经胶质细胞嘌呤能受体-P2Y12R活化所触发。除嘌呤能信号之外,大量神经元信号分子正向或负向调控小神经胶质细胞的移动,这对调节病理条件下的小神经胶质细胞功能性活化起重要作用。本综述重点讨论小神经胶质细胞的动态移动过程,并描述几种在正常和病理脑组织中调节小神经胶质细胞移动的重要信号分子及其作用。

关键词：小神经胶质细胞趋化作用迁移过程延伸 ATP 腺苷

Compartmentalization of local cAMP signaling in neuronal growth and survival

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第3期15卷 453-454页

作者： Tomasz Boczek Michael S.Kapiloff department of Ophthalmology Byers Eye InstituteMary M.and Sash A.Spencer Center for Vision ResearchStanford University School of MedicinePalo AltoCAUSA department of Molecular neurochemistry Medical University of LodzPoland

Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and *** highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite *** these,cyclic adenosine monophosphate(cAMP)is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream *** the central nervous system(CNS),cAMP-dependent signaling is involved in growth cone motility,neuronal metabolism,axon extension in vitro,neuroprotection,and survival in *** complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes.

关键词： metabolism specificity integrate