A-kinase anchoring protein-mediated compartmentalization of pro-survival signaling in the retina

作     者：Joanna Mackiewicz Tomasz Boczek 

作者机构：Department of Molecular NeurochemistryMedical University of LodzLodzPoland 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第2期

页      面：479-480页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：supported by National Science Center(Narodowe Centrum Nauki)grant No.UMO-2019/33/B/NZ4/00587 to TB. 

主　　题：degeneration utilizing irreversible 

摘      要：The retina plays a fundamental role in the process of vision,serving as the primary interface between external visual stimuli and the central nervous system.Because the retina is exposed to a variety of environmental stresses and deleterious insults,it is susceptible to a spectrum of pathological conditions that can detrimentally affect vision.This often leads to irreversible vision loss due to the injury of specific cell types.For instance,inherited retinal degeneration and age-related macular degeneration can lead to the death of photoreceptors,while conditions like glaucoma and optic nerve injury can result in the loss of ganglion cells.The precise pathological mechanisms driving retinal degeneration remain largely elusive,although research utilizing mouse models suggests that disruptions in intracellular signal transduction pathways may play a pivotal role.Signaling pathways within the retina orchestrate various aspects of retinal physiology,including phototransduction,synaptic transmission,and neuronal survival.