Compartmentalization of local cAMP signaling in neuronal growth and survival

作     者：Tomasz Boczek Michael S.Kapiloff Tomasz Boczek;Michael S. Kapiloff

作者机构：Department of OphthalmologyByers Eye InstituteMary M.and Sash A.Spencer Center for Vision ResearchStanford University School of MedicinePalo AltoCAUSA Department of Molecular NeurochemistryMedical University of LodzPoland 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第3期

页      面：453-454页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported in part by National Institutes of Health Grant EY026766(to MSK) 

主　　题：metabolism specificity integrate 

摘      要：Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and *** highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite *** these,cyclic adenosine monophosphate(cAMP)is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream *** the central nervous system(CNS),cAMP-dependent signaling is involved in growth cone motility,neuronal metabolism,axon extension in vitro,neuroprotection,and survival in *** complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes.