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Dissolvable temporary barrier:a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

Bio-Design and Manufacturing 2024年第2期7卷 153-166页

作者： Ding Wang Qinyu Li Chenyang Zhou Zhangjie Li Kangyi Lu Yijun Liu Lian Xuan Xiaolin Wang department of micro/nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory of Advanced micro and nano Manufacture Technology Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China

A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as *** hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a ***,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo ***,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular *** key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the *** and multiple tissue compartments with different geometries can be established using either straight or curved DTB *** effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor *** a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan ***,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.

关键词： Dissolvable temporary barrier Hydrogel patterning microfluidics Organ-on-a-chip Vascularization

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Exploring Deep Learning Methods for Computer Vision Applications across Multiple Sectors:Challenges and Future Trends

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Computer Modeling in engineering & sciences 2024年第4期139卷 103-141页

作者： Narayanan Ganesh Rajendran Shankar Miroslav Mahdal Janakiraman SenthilMurugan Jasgurpreet Singh Chohan Kanak Kalita School of Computer science and engineering Vellore Institute of TechnologyChennai600127India department of Computer science and engineering Koneru Lakshmaiah Education FoundationVaddeswaram522502India department of Control Systems and Instrumentation Faculty of Mechanical EngineeringVSB-Technical University of OstravaOstrava70800Czech Republic department of Computer science and engineering Vel Tech High Tech Dr.Rangarajan Dr.Sakunthala Engineering CollegeChennai600062India department of mechanical engineering and University Centre for Research&Development Chandigarh UniversityMohali140413India department of mechanical engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyAvadi600062India

Computer vision(CV)was developed for computers and other systems to act or make recommendations based on visual inputs,such as digital photos,movies,and other *** learning(DL)methods are more successful than other traditional machine learning(ML)methods *** techniques can produce state-of-the-art results for difficult CV problems like picture categorization,object detection,and face *** this review,a structured discussion on the history,methods,and applications of DL methods to CV problems is *** sector-wise presentation of applications in this papermay be particularly useful for researchers in niche fields who have limited or introductory knowledge of DL methods and *** review will provide readers with context and examples of how these techniques can be applied to specific areas.A curated list of popular datasets and a brief description of them are also included for the benefit of readers.

关键词： Neural network machine vision classification object detection deep learning

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Dual-Porosity Apparent Permeability Models of Unconventional Gas Migration Based on Biot’s Porous Media

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Acta Mechanica Solida Sinica 2024年第3期37卷 406-415页

作者： Bin Gu Hongyuan Liu Yiuwing Mai Bing Wang School of Manufacturing science and engineering Key Laboratory of Testing for Manufacturing ProcessMinistry of EducationSouthwest University of Science and TechnologyMianyang621010China School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneySydneyNSW2006Australia department of mechanical engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Stress-dependent permeability models are developed for the organic pores and inorganic cleats/fractures in unconventional gas reservoirs,which are modeled as Biot’s porous media of *** considering multiple flow mechanisms such as dynamic effects of gas flow and surface diffusion,apparent permeability models are obtained to investigate the characteristics of unconventional gas *** to the gas transfer in single-porosity reservoirs,the gas migration ability of cleats in dual-porosity stratums rarely changes while that of organic pores is greatly improved because cleats sustain major geomechanical shrinkage deformation when the pore pressure ***,the mass flux of reservoirs is dominated by the mass flux of cleats,which has a lower peak value,but a much longer production term than those in single-porosity reservoirs due to the interaction between organic pores and *** analysis is conducted to identify key factors significantly impacting mass flux in unconventional *** for the mass flux variation are also explored in terms of gas migration ability and pore pressure distribution.

关键词： Unconventional gas migration Apparent permeability Dual-porosity Stress dependence Multiple flow mechanisms

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Simulation Study of Diesel Spray Tilt Angle and Ammonia Energy Ratio Effect on Ammonia-Diesel Dual-Fuel Engine Performance

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Energy engineering 2024年第9期121卷 2603-2620页

作者： Zhifeng Zhao Xuelong Miao Xu Chen Jinbao Zheng Yage Di Zhenjie Bao Zhuo Yang mechanical and Automotive engineering School Shanghai University of Engineering ScienceShanghai201620China

Ammonia-diesel dual fuel(ADDF)engines for transportation applications are an important way to reduce carbon *** order to achieve better combustion of ammonia in diesel engines.A small-bore single-cylinder engine was converted into an ADDF engine with the help of mature computational fluid dynamics(CFD)simulation software to investigate the performance of an engine with a high ammonia energy ratio(AER),and to study the effect of spray tilt angle on ADDF *** results showed that the increase in AER reduced nitric oxide(NO)and nitrogen dioxide(NO2)emissions but increased nitrous oxide(N2O)and unburned ammonia *** in the range of 50%-70%achieved lower greenhouse gases(GHG)emissions than the pure diesel *** to the pure diesel mode,when the AER was 60%,the indicated thermal efficiency(ITE)was increased by 0.2%and the GHG emissions were decreased by 22.3%,but carbon monoxide(CO)and Hydrocarbon(HC)emissions were *** the in-cylinder combustion temperature or high-temperature region range of the ADDF engine could reduce GHG *** an AER of 60%,an increase in the spray tilt angle helped the ammonia combustion in the residual gap to reduce the unburned ammonia *** to the pure diesel mode with a spray tilt angle of 75°,an AER of 60%with a spray tilt angle of 77.5°improved the ITE by 1.5%,and reduced theGHGemissions by 25.7%.Adjusting the spray tilt angle of theADDFengine also *** is an effective way to improve ADDF engine performance by adjusting the spray tilt angle.

关键词： Ammonia-diesel engine ammonia energy ratio greenhouse gases carbon-free fuel

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Efficient concentration of trace analyte with ordered hotspot construction for a robust and sensitive SERS platform

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International Journal of Extreme Manufacturing 2024年第3期6卷 532-542页

作者： Youdi Hu Yanlei Hu Zhenyu Wang Jiale Yong Wei Xiong Dong Wu Shixiang Xu Shenzhen Key Laboratory of micro-nano Photonic Information Technology College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China CAS Key Laboratory of mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubeiPeople’s Republic of China

Surface-enhanced Raman scattering(SERS)platform,which enables trace analyte detection,has important application *** structuring/modifying the surface of the SERSsubstrate,analyte in highly diluted solutions can be concentrated into localized active areas for highly sensitive ***,subject to the difficulty of the fabrication process,itremains challenging to balance hot-spot construction and the concentration capacity of analyte ***,preparing SERS substrates with densely ordered hot spots andefficient concentration capacity is of great significance for highly sensitive ***,we propose an Ag and fluoroalkyl-modified hierarchical armour substrate(Ag/F-HA),which has a double-layer stacking design to combine analyte concentration with hotspot *** microarmour structure is fabricated by femtosecond-laser processing to serve as asuperhydrophobic and low-adhesive surface to concentrate analyte,while the anodic aluminium oxide(AAO)template creates a nanopillar array serving as dense and ordered hot *** the synergistic action of hot spots and analyte concentration,Ag/F-HA achieves a detectionlimit down to 10^(-7)M doxorubicin(DOX)molecules with a RSD of 7.69%.Additionally,Ag/F-HA exhibits excellent robustness to resist external disturbances such as liquid splash or *** on our strategy,SERS substrates with directional analyte concentrations are further explored by patterning microcone arrays with *** work opens a way to the realistic implementation of SERS in diverse scenarios.

关键词： surface-enhanced Raman scattering anodic aluminium oxide femtosecond laser processing concentration of trace analytes mechanical robustness

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A Study of the Effect of the Miller Cycle on the Combustion of a Supercharged Marine Diesel Engine

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Energy engineering 2024年第5期121卷 1363-1380页

作者： Lingjie Zhao Cong Li mechanical and Automotive engineering School Shanghai University of Engineering ScienceShanghai201600China

The Miller cycle is a program that effectively reduces NOx emissions from marine diesel engines by lowering the maximum combustion temperature in the cylinder,thereby reducing NOx *** effectively investigate the impact of Miller cycle optimum combustion performance and emission capability under high load conditions,this study will perform a one-dimensional simulation of the performance of a marine diesel engine,as well as a threedimensional simulation of the combustion in the cylinder.A 6-cylinder four-stroke single-stage supercharged diesel engine is taken as the research *** chassis dynamometer and other related equipment are used to build the test system,carry out the diesel engine bench test,and collect experimental *** simulation results are compared with the test results,and the error is less than 5%.In this study,the authors will use simulation software to simulate several Miller cycle scenarios designed for early inlet valve closure and analyze the impact of the Miller cycle on combustion and emissions at 100%load *** comparing the flow field distribution of the engine at 1500 r/min condition,it was found that proper EIVC can prolong the ignition latency period and homogeneous fuel-air mixture combustion acceleration,but it can reduce pressure and temperature within the piston chamber and NOx ***,the Miller cycle reduces end-of-compression temperatures,which increases combustion duration and exhaust temperatures,making it difficult to improve fuel economy at the optimum fuel consumption point,and closing the intake valves prematurely leads to excessive fuel ***,temperature and heat release rate within the piston chamber,NOx,and SOOT generation were significantly enhanced.

关键词： Miller cycle EIVC combustion NOx emissions marine diesel

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Numerical and experimental investigation on hydraulic-electric rock fragmentation of heterogeneous granite

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International Journal of Mining science and Technology 2024年第1期34卷 15-29页

作者： Xiaohua Zhu Ling He Weiji Liu Yunxu Luo Youjian Zhang Wuji Tang School of Mechatronic engineering Southwest Petroleum UniversityChengdu 610500China School of mechanical engineering Sichuan University of Science and EngineeringYibin 643002China

Hydraulic-electric rock fragmentation(HERF)plays a significant role in improving the efficiency of high voltage pulse rock ***,the underlying mechanism of HERF remains *** this study,considering the heterogeneity of the rock,microscopic thermodynamic properties,and shockwave time domain waveforms,based on the shockwave model,digital imaging technology and the discrete element method,the cyclic loading numerical simulations of HERF is achieved by coupling electrical,thermal,and solid mechanics under different formation temperatures,confining pressure,initial peak voltage,electrode bit diameter,and loading ***,the HERF discharge system is conducive to the laboratory experiments with various electrical parameters and the resulting broken pits are numerically reconstructed to obtain the geometric *** results show that,the completely broken area consists of powdery rock *** the pre-broken zone,the mineral cementation of the rock determines the transition of type CⅠcracks to type CⅡand type CⅢ***,the peak pressure of the shockwave increased with initial peak voltage but decreased with electrode bit diameter,while the wave front time ***,increasing well depth,formation temperature and confining pressure augment and inhibit HERF,but once confining pressure surpassed the threshold of 60 MPa for 152.40,215.90,and 228.60 mm electrode bits,and 40 MPa for 309.88 mm electrode bits,HERF is ***,for the same kind of rock,the volume and width of the broken pit increase with higher initial peak voltage and rock fissures will promote ***,the electrode drill bit with a 215.90 mm diameter is more suitable for drilling pink *** research contributes to a better microscopic understanding of HERF and provides valuable insights for electrode bit selection,as well as the optimization of circuit parameters for HERF technology.

关键词： Hydraulic-electric rock fragmentation Shockwave Thermodynamics microcracks Weak Linear Parallel Bond Model

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A Temporal Convolutional Network Based Hybrid Model for Short-term Electricity Price Forecasting

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1119-1130页

作者： Haoran Zhang Weihao Hu Di Cao Qi Huang Zhe Chen Frede Blaabjerg School of mechanical and Electrical engineering University of Electronic Science and Technology of ChinaChengduChina department of Energy Technology Aalborg UniversityAalborgDenmark IEEE

Electricity prices have complex features,such as high frequency,multiple seasonality,and *** factors will make the prediction of electricity prices ***,accurate electricity price prediction is important for energy producers and consumers to develop bidding *** improve the accuracy of prediction by using each algorithms’advantages,this paper proposes a hybrid model that uses the Empirical Mode Decomposition(EMD),Autoregressive Integrated Moving Average(ARIMA),and Temporal Convolutional Network(TCN).EMD is used to decompose the electricity prices into low and high frequency *** frequency components are forecasted by the ARIMA model and the high frequency series are predicted by the TCN *** results using the realistic electricity price data from Pennsylvania-New Jersey-Maryland(PJM)electricity markets show that the proposed method has a higher prediction accuracy than other single methods and hybrid methods.

关键词： Autoregressive integrated moving average model electricity price forecasting empirical mode decomposition temporal convolutional network

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Aerosol jet printing of surface acoustic wave microfluidic devices

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microsystems & nanoengineering 2024年第1期10卷 231-242页

作者： Joseph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong James L.Doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron D.Franklin Tony Jun Huang department of Biomedical engineering Duke UniversityDurhamNC 27708USA department of Electrical and Computer engineering Duke UniversityDurhamNC 27708USA department of mechanical engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord department of mechanical engineering and Materials science Duke UniversityDurhamNC 27708USA Deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid ***,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based *** simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser Doppler ***,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration ***,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

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Performance-control-orientated hybrid metal additive manufacturing technologies:state of the art,challenges,and future trends

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International Journal of Extreme Manufacturing 2024年第3期6卷 274-328页

作者： Jiming Lv Yuchen Liang Xiang Xu Gang Xu Hongmei Zhang Haifei Lu Kaiyu Luo Jie Cai Jinzhong Lu School of mechanical engineering Jiangsu UniversityZhenjiang 212013People’s Republic of China School of mechanical engineering Jiangsu University of Science and TechnologyZhenjiang 212003People’s Republic of China

Metal additive manufacturing(AM)technologies have made significant progress in the basic theoretical field since their invention in the ***,performance instability during continuous processing,such as thermal history,residual stress accumulation,and columnar grain epitaxial growth,consistently hinders their broad application in standardized industrial *** overcome these challenges,performance-control-oriented hybrid AM(HAM)technologies have been *** technologies,by leveraging external auxiliary processes,aim to regulate microstructural evolution and mechanical properties during metal *** paper provides a systematic and detailed review of performance-control-oriented HAM technology,which is categorized into two main groups:energy field-assisted AM(EFed AM,***,electromagnetic,and heat)technologies and interlayer plastic deformation-assisted AM(IPDed AM,*** shock peening,rolling,ultrasonic peening,and friction stir process)*** review covers the influence of external energy fields on the melting,flow,and solidification behavior of materials,and the regulatory effects of interlayer plastic deformation on grain refinement,nucleation,and ***,the role of performance-control-oriented HAM technologies in managing residual stress conversion,metallurgical defect closure,mechanical property improvement,and anisotropy regulation is thoroughly reviewed and *** review concludes with an analysis of future development trends in EFed AM and IPDed AM technologies.

关键词： hybrid additive manufacturing in-situ/interlayer plastic deformation auxiliary energy fields microstructure customization mechanical properties enhancement

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