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Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： Miao Liu Haiqing Zhang Zhichao Wang Tingting Mo Xuefeng Lai Yaling He Minghui Jiang Meian He Weijia Kong Tangchun Wu Xiaomin Zhang department of Occupational and Environmental health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was *** present study included 15,827 participants from the Dongfeng–Tongji cohort *** risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing *** conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with *** showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 *** 10:00 *** to those with bedtime>10:00 *** 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

New insights into the therapeutic approaches for the treatment of tauopathies

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Neural Regeneration Research 2024年第5期19卷 1020-1026页

作者： Himanshi Singh Asmita Das Mohammad Moshahid Khan Tayebeh Pourmotabbed department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA department of Biotechnology Delhi Technological UniversityShahbad DaulatpurDelhiIndia department of Neurology College of MedicineUniversity of Tennessee Health Science CenterMemphisTNUSA Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA Center for Muscle Metabolism and NeuropathologyDivision of Regenerative and Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein *** development of tauopathies cannot currently be stopped or slowed down by treatment *** the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective ***,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of ***,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side *** this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关键词： dementia gene therapies immunotherapy neurodegeneration oligonucleotides tau tauopathies therapies

Resident immune responses to spinal cord injury:role of astrocytes and microglia

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Neural Regeneration Research 2024年第8期19卷 1678-1685页

作者： Sydney Brockie Cindy Zhou Michael G.Fehlings Division of Genetics and development Krembil Research InstituteUniversity Health NetworkTorontoONCanada Institute of Medical science University of TorontoTorontoONCanada Division of Neurosurgery and Spine Program Department of SurgeryUniversity of TorontoTorontoONCanada

Spinal cord injury can be traumatic or non-traumatic in origin,with the latter rising in incidence and prevalence with the aging demographics of our *** r,as the global population ages,individuals with co-existent degenerative spinal pathology comprise a growing number of traumatic spinal cord injury cases,especially involving the cervical spinal *** makes recovery and treatment approaches particula rly challenging as age and comorbidities may limit regenerative *** these reasons,it is critical to better understand the complex milieu of spinal cord injury lesion pathobiology and the ensuing inflammatory *** review discusses microglia-specific purinergic and cytokine signaling pathways,as well as microglial modulation of synaptic stability and plasticity after ***,we evaluate the role of astrocytes in neurotransmission and calcium signaling,as well as their border-forming response to neural *** the inflammatory and reparative roles of these cells have eluded our complete understanding and remain key therapeutic targets due to their extensive structural and functional roles in the nervous *** advances have shed light on the roles of glia in neurotransmission and reparative injury responses that will change how interventions are *** key processes and existing knowledge gaps will allow future research to effectively target these cells and harness their regenerative potential.

关键词： astrocytes glial signaling microglia spinal cord injury synaptic transmission

Machine learning applications in stroke medicine:advancements,challenges,and future prospectives

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Neural Regeneration Research 2024年第4期19卷 769-773页

作者： Mario Daidone Sergio Ferrantelli Antonino Tuttolomondo Internal Medicine and Stroke Care Ward Department of Health PromotionMother and Child CareInternal Medicine and Medical SpecialtiesUniversity of Palermo Molecular and Clinical Medicine PhD Program University of Palermo

Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient *** recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine *** abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke *** introduced machine learning algorithms have been extensively employed in all the fields of stroke *** learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient *** the tremendous potential of machine learning in stroke medicine,several challenges must be *** include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and *** addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke *** learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved *** research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of *** review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic *** the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling dis

关键词： cerebrovascular disease deep learning machine learning reinforcement learning stroke stroke therapy supervised learning unsupervised learning

A marathon,not a sprint:Increasing population physical activity as a legacy of sports mega-events

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Journal of Sport and health science 2024年第6期13卷 732-735页

作者： Fiona C.Bull Paul J.Simpson Physical Activity Unit Department of Health PromotionWorld Health OrganizationGeneva CH-1211Switzerland The BMJ London WC1H 9JPUK

*** matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and *** also matters.1 The cost of hosting a major international tournament is eye-wateringly *** governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent.

关键词： return dollar sport

Refinement modeling and verification of secure operating systems for communication in digital twins

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Digital Communications and Networks 2024年第2期10卷 304-314页

作者： Zhenjiang Qian Gaofei Sun Xiaoshuang Xing Gaurav Dhiman School of Computer science and Engineering Changshu Institute of TechnologySuzhou215500China University Centre for Research and development Department of Computer Science and EngineeringChandigarh UniversityMohali140413India department of Computer science and Engineering Graphic Era Deemed to be UniversityDehradun248002India

In traditional digital twin communication system testing,we can apply test cases as completely as possible in order to ensure the correctness of the system implementation,and even then,there is no guarantee that the digital twin communication system implementation is completely *** verification is currently recognized as a method to ensure the correctness of software system for communication in digital twins because it uses rigorous mathematical methods to verify the correctness of systems for communication in digital twins and can effectively help system designers determine whether the system is designed and implemented *** this paper,we use the interactive theorem proving tool Isabelle/HOL to construct the formal model of the X86 architecture,and to model the related assembly *** verification result shows that the system states obtained after the operations of relevant assembly instructions is consistent with the expected states,indicating that the system meets the design expectations.

关键词： Theorem proving Isabelle/HOL Formal verification System modeling Correctness verification

Synergistic extraction of rare earth elements and alumina from coal fly ash by potassium pyrosulfate

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Journal of Rare Earths 2024年第4期42卷 749-758页

作者： Jingjing Zou Yiping Sun Chunbin Guo Daye Chen Yonghong Song Yongfeng Wu Zhaotianhui Li department of Environment science and Engineering Liaoning Technical UniversityFuxin23000China department of Materials science and Engineering Liaoning Technical UniversityFuxin123000 China Technology Research and development department Chinese Institute of Coal ScienceBeijing100013China Shenhua Zhungeer Energy and Resource Comprehensive development Co. Ltd.Erdos10300China Liaoning Yingguan High-tech Ceramic Co. Ltd.Jinzhou121213China

Although coal fly ash(CFA)contains a high content of rare earth elements(REEs),the related extraction methods have limitations because of their low efficiencies,high levels of energy consumption,and other *** address these problems,in this study,we examined the coextraction of REEs and Al_(2)O_(3)from two types of Al_(2)O_(3)-rich CFA,pulverized CFA(PCFA)and circulating fluidized bed fly ash(CFBFA)using low-temperature calcination in the presence of K_(2)S_(2)O_(7).The total REEs,heavy REEs(HREEs),and light REEs(LREEs)extraction efficiencies were determined using different K_(2)S_(2)O_(7)/Al_(2)O_(3) molar ratios and calcination temperatures and correlated with the Al_(2)O_(3) extraction efficiency using Pearson correlation coefficient *** REEs are concentrated within CFA particles encapsulated in an aluminosilicate glass phase,and the REEs extraction efficiency is related to the form of Al in *** extraction efficiencies of Al_(2)O_(3) and REEs increase as the K_(2)S_(2)O_(7)/Al_(2)O_(3) molar ratio and calcination temperature increase,and the extraction selectivity of the more industrially valuable HREEs from CFBFA is *** high K_(2)S_(2)O_(7)/Al_(2)O_(3) molar ratios,the extraction of REEs from PCFA is more efficient than that from CFBFA with the regeneration of the highly active Al-O-Si bonds in *** Al_(2)O_(3) extraction efficiencies of PCFA as well as CFBFA correlate strongly with the total REEs,HREEs,and LREEs extraction *** developed extraction technology has the potential to promote CFA valorization and expand REEs resources,thus mitigating the bottlenecks of REEs procurement.

关键词： Rare earths Alumina Coal fly ash Potassium pyrosulfate Calcination Extraction

Device-measured physical activity and sedentary time in the Nordic countries:A scoping review of population-based studies

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Journal of Sport and health science 2024年第5期13卷 650-660页

作者： Ing-Mari Dohrn Jakob Tarp Jostein Steene-Johannessen Tommi Vasankari Maria Hagströmer Division of Physiotherapy Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet14183 HuddingeSweden department of Sports Medicine Norwegian School of Sports Sciences0806 OsloNorway UKK Institute for health promotion Research 33500 TampereFinland Faculty of Medicine and health Technology Tampere University33100 TampereFinland Academic Primary health Care Centre Region Stockholm13365 StockholmSweden

Purpose:The purpose of this scoping review was to summarize and describe the methodology and results from population-based studies of physical activity and sedentary time measured with devices in the Nordic countries(Denmark,Finland,Iceland,Norway,and Sweden)and published in 2000 or ***:A systematic search was carried out in PubMed and Web of science in June 2023 using predefined search ***:Fourteen unique research projects or surveillance studies were ***,2 surveillance studies published by national agencies were included,resulting in a total of 16 studies for *** surveillance systems exist in Finland and Norway,with regular survey waves in school-aged children/adolescents and *** Denmark,recent nationally representative data have been collected in school children *** far,Sweden has no regular national surveillance system using device-based data *** studies were found from *** first study was conducted in 2001 and the most recent in 2022,with most data collected from 2016 to *** studies included children/adole scents 6-18 years,no study included *** total 11 studies included adults,of which 8 also covered older *** study focused specifically on older *** analytical sample size ranged from 205 to 27,*** methodology is presented,such as information on sampling strategy,device type and placement,wear protocols,and physical activity classification *** of physical activity and sedentary time in children/adolescents,adults,and older adults across the Nordic countries are ***:A growing implementation of device-based population surveillance of physical activity and sedentary behavior in the Nordic countries has been *** variety of devices,placement,and data procedures both within and between the Nordic countries highlights the challenges when it comes to comparing study outcomes as well as the need for more standa

关键词： Accelerometer Light intensity Moderate-vigorous intensity Surveillance Wearable devices

Association of Hypertension and Plant-based Dietary Patterns on Cognitive Impairment: A Nationwide Cohort Study in China

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Food science and Human Wellness 2024年

作者： Fang Liang Jialin Fu Gabrielle Turner-McGrievy Yechuang Wang Kai Ding Jing Zeng Justin B Moore Rui Li Chengdu High-tech Zone Center for Diseases Control and Prevention School of Public health Wuhan University department of Implementation science Division of Public health sciences Wake Forest School of Medicine department of health promotion Education and Behavior Arnold School of Public health University of South Carolina Columbia SC USA School of Nursing Wuhan University

This study investigated the association of hypertension with cognitive impairment and determined whether better adherence to plant-based diet (PBD) patterns may modify the association. We analyzed 4485 elderly individuals with normal cognition at baseline from the Chinese Longitudinal healthy Longevity Survey (2011-2018). Cognitive function was assessed by the Mini-mental State Examination (MMSE)， and cognitive impairment was defined as an MMSE score below 18 points. Diet patterns were assessed using the overall plant-based diet index (PDI)， healthful plant-based diet index (hPDI)， and unhealthful plant-based diet index (uPDI) derived from a simplified food frequency questionnaire (FFQ). Blood pressure was measured through physical examination. Cox proportional hazard regression and restricted cubic spline were performed. Participants with hypertension had an increased risk of cognitive impairment compared with normal group. The associations between hypertension and cognitive impairment were more pronounced among participants with lower PDI than those with higher PDI， among participants with lower hPDI than those with higher hPDI， and among participants with higher uPDI than those with lower uPDI. A healthful PBD pattern may attenuate hypertension-induced cognitive impairment， while an unhealthful PBD pattern may exacerbate hypertension-induced cognitive impairment in elderly. Adherence to healthful PBD pattern could be used to prevent or mitigate adverse neurological effects in the hypertensive population.

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