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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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A three-dimensional model for the transportation of Fe and Mn in Arha Reservoir

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Journal of Environmental Sciences 2000年第2期12卷 36-46页

作者： Xiao-hong, C. Brimicombe, A.J. department of geography Zhongshan University Guangzhou 510275 China

Coupling with a three dimensional (3D) hydrodynamic model and a suspended solids model, a 3D model for the transport of Fe and Mn in Arha Reservoir, China, was developed. The 3D velocity fields for the flood season are computed to drive the 3D model of Fe and Mn in which the processes of advection, diffusion, redox, sorption, desorption, deposition, and re suspension are included. The model has been calibrated by matching observed fluid, suspended solids, and total concentrations of Fe and Mn in the water column and in the sediment, successively. The model simulated both horizontal and vertical gradients of Fe and Mn in Arha Reservoir. It was found that Fe and especially Mn stratify in accordance with the stratification of DO during summer. The redox cycles across the water sediment interface has a principal role in the rise of Fe and Mn concentrations in the overlying water. It was also found that Fe and Mn loadings from the tributaries have a carryover effect on the water quality through a secondary contamination in the reservoir.

关键词： three dimensional model Fe Mn transport flow field Arha Reservoir CLC number: X1 Document code: A

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Danxia geomorphology of China: A review

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Chinese Science Bulletin 2001年第S1期46卷 38-45页

作者： PENG Huadepartment of geography, zhongshan university, Guangzhou 510275, China (e-mail: eesph@***) 1. department of geography Zhongshan University 510275 Guangzhou China

Danxia Landform belongs to red terrestrial clastic rock landform, which is characterized by its red cliffed scarp. The development of Danxia Landform research in China experienced three historic stages, i.e. initial establishment, taking shape and expanding since the concept 'Danxia Landform' raised by Prof. Chen Guoda in 1939. As a new branch of geomorphology, Danxia geomorphology research is now stepping its ripe stage. In the 1990s, the search enters into an unprecedented grand occasion at the prompting of tourism exploit.

关键词： Danxia Landform Danxia geomorphology red beds terrestrial clastic rock scenery resource.

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A DISCUSSION ON SEVERAL PROBLEMS OF GEOMOR-PHOLOGICAL DEVELOPMENT IN THE YANGTZE RIVER ESTUARY AND DELTA DURING THE HOLOCENE

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Journal of Geographical Sciences 1992年第2期 89-100页

作者： Li Chunchu department of geography Zhongshan University

Three problems encountered in the studies on the Yangtze River Estuary-delta are discussed in this *** first involves the sediment supplied and development processes of the ancient beach-ridge plain in the southern side of recent Yangtze River *** second deals with the origin of Lake Taihu depression and the third is concerned with the stages and the differences of the development in Yangtze River Estuary-delta during the last 6000 years.

关键词： Yangtze River Lake Taihu estuary delta beachridge plain

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Analysis of Spatial Autocorrelation Patterns of Heavy and Super-Heavy Rainfall in Iran

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Advances in Atmospheric Sciences 2017年第9期34卷 1069-1081页

作者： Iman ROUSTA Mehdi DOOSTKAMIAN Esmaeil HAGHIGHI Hamid Reza GHAFARIAN MALAMIRI Parvane YARAHMADI department of geography Yazd University department of geography Zanjan University department of geography Tabriz University department of geography Khwarizmi University

Rainfall is a highly variable climatic element, and rainfall-related changes occur in spatial and temporal dimensions within a regional climate. The purpose of this study is to investigate the spatial autocorrelation changes of Iran＇s heavy and super-heavy rainfall over the past 40 years. For this purpose, the daily rainfall data of 664 meteorological stations between 1971 and 2011 are used. To analyze the changes in rainfall within a decade, geostatistical techniques like spatial autocorrelation analysis of hot spots, based on the Getis-Ord Gi statistic, are employed. Furthermore, programming features in MATLAB, Surfer, and GIS are used. The results indicate that the Caspian coast, the northwest and west of the western foothills of the Zagros Mountains of Iran, the inner regions of Iran, and southern parts of Southeast and Northeast Iran, have the highest likelihood of heavy and super-heavy rainfall. The spatial pattern of heavy rainfall shows that, despite its oscillation in different periods, the maximum positive spatial autocorrelation pattern of heavy rainfall includes areas of the west, northwest and west coast of the Caspian Sea. On the other hand, a negative spatial autocorrelation pattern of heavy rainfall is observed in central Iran and parts of the east, particularly in Zabul. Finally, it is found that patterns of super-heavy rainfall are similar to those of heavy rainfall.

关键词： Iran heavy rainfall super-heavy rainfall spatial autocorrelation Gi index

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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

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Wetland and habitat dynamics in the evolving landscape of the Middle Yangtze River Basin

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Journal of Geographical Sciences 2025年第1期 88-111页

作者： YANG Peng SUN Kaiya ZHU Yanchao XIA Jun HUANG Heqing SONG Jingxia SHI Xiaorui LU Xixi Hubei Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information Engineering China University of Geosciences department of geography National University of Singapore State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University

Wetlands play a critical role in the global environment. The Middle Yangtze River Basin(MYRB), known for its abundant wetland resources, has experienced notable changes resulting from the complex interplay of environmental factors. Therefore, we investigated the spatiotemporal characteristics of wetland ecological quality in the MYRB from 2001 to *** the random forest(RF) regression algorithm and patch-generated land-use simulation(PLUS) model, we forecasted variations in wetland habitat quality and their determinants under the Shared Socioeconomic Pathway-Representative Concentration Pathway(SSPRCP) framework from 2035 to 2095. The main findings are as follows:(1) The RF algorithm was optimal for land-use and land-cover(LULC) classification in the MYRB from 2001 to 2020,when notable changes were observed in water bodies and buildings. However, the forested area exhibited an increase and decrease of 3.9% and 1.2% under the SSP1-2.6 and SSP5-8.5 scenarios, respectively, whereas farmland exhibited a diminishing trend.(2) Wetlands were primarily concentrated in the central and eastern MYRB, with counties in the southwest exhibiting superior ecological-environmental quality from 2001 to 2020. Notably,wetland coverage revealed significantly high level, significant changes, frequent but relatively minor changes under the SSP1-2.6, SSP2-4.5, and SSP 5-8.5 scenarios, respectively.(3)Regions with lower habitat quality were primarily concentrated in urbanized areas characterized by frequent human activities, indicating a clear degradation in habitat quality across different scenarios. In conclusion, we established a foundational framework for future investigations into the eco-hydrological processes and ecosystem quality of watersheds.

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Value of incorporating geospatial information into the prediction of on-street parking occupancy - A case study

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Geo-Spatial Information Science 2021年第3期24卷 438-457页

作者： Michael Balmer Robert Weibel Haosheng Huang department of geography University of ZurichZurichSwitzerland department of geography Ghent UniversityGhentBelgium

In light of growing urban traffic,car parking becomes increasingly critical for cities to *** a result,the prediction of parking occupancy has sparked significant research interest in recent *** many external data sources have been considered in the prediction models,the underlying geographic context has mostly been ***,in order to study the contribution of geospatial information to parking occupancy prediction models,road network centrality,land use,and Point of Interest(POI)data were incorporated in Random Forest(RF)and Artificial Neural Network(ANN,specifically Feedforward Neural Network FFNN)prediction models in this *** performances were compared to a baseline,which only considers historical and temporal input ***,the influence of the amount of training data,the prediction horizon,and the spatial variation of the prediction were *** results show that the inclusion of geospatial information led to a performance improvement of up to 25%compared to the ***,as the prediction horizon expanded,predictions became less reliable,while the relevance of geospatial data *** general,land use and POI data proved to be more beneficial than road network *** amount of training data did not have a significant influence on the performance of the RF *** ANN model,conversely,achieved optimal results on a training input of 5 *** attributable to varying occupancy patterns,prediction performance disparities could be identified for different parking districts and street ***,the RF model outperformed the ANN model on all predictions.

关键词： Parking occupancy prediction on-street parking geospatial information machine learning

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Bank erosion in an Andean páramo river system: Implications for hydro-development and carbon dynamics in the neotropical Andes

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Journal of Mountain Science 2019年第2期16卷 243-255页

作者： Derek J.MARTIN Christopher ELY Beverley C.WEMPLE department of geography and Planning Appalachian State University department of geography University of Vermont

The páramo of the Northern Andes provide critically important ecosystem services to the Northern Andean region in the form of water provisioning and carbon sequestration, both of which are a result of the páramo?s organic-rich soils. Little is known, however, about the hydro-geomorphic characteristics of the rivers that drain these ecosystems. With impending plans for widespread hydro-development and increasing implementation of carbon-sequestering compensation for ecosystem services programs in the region it is imperative that we develop a thorough understanding of the hydrogeomorphic role that rivers play in this unique ecosystem. The objective of this study was to quantify bank erosion along an Amazonian headwater stream draining a small, relatively undisturbed páramo catchment to gain a better understanding of the natural erosion regime and the resulting sediment contributions from this unique ecosystem. This study implemented a combination of field, laboratory, and Geographic Information Systems techniques to quantify bank erosion rates and determine a bank erosion sediment yield from the Ningar River, a small páramo catchment(22.7 km^2) located in the eastern Andean cordillera of Ecuador. Results show that bank erosion rates range from 3.0 to ≥ 390.0 mm/yr, are highly episodic, and yield at least 487 tons of sediment annually to the Ningar River. These results imply that 1) páramo ecosystems substantially contribute to the sediment load of the Amazon River basin; 2) bank erosion is a potentially significant flux component of basin-scale carbon cycles in páramo ecosystems; and 3) hydrologic alteration campaigns(dam building) will likely critically alter these contributions and concomitantly disconnect a critical source of sediment and nutrients to downstream ecosystems.

关键词： Bank erosion Páramo Fluvial geomorphology Andes

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Noise Effects on Oscillator Network of Transcription Regulators

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Communications in Theoretical Physics 2002年第10期38卷 497-502页

作者： WANG Xian-Ju AI Bao-Quan LIU Guo-Tao LIU Liang-Gang department of Physics Zhongshan University Guangzhou 510275 China Department of Physics Zhongshan University Guangzhou 510275 China Department of Physics Zhongshan University Guangzhou 510275 China Department of Physics Zhongshan University Guangzhou 510275 China

Based on the model describing the regulation of the PRM operator region of λ phage proposed by Jeff Hastyet al., we study the noise effects on the oscillator network. We find that the additive noise cannot change the period andthe amplitude of the relaxation oscillator, but in the multiplicative case, the period of the relaxation oscillator increasesto a constant value with the increase of the strength of noise, and the amplitude of the relaxation oscillator also showsincreases with the increase of the strength of noise. This novel results suggest that an external multiplicative noise sourcecould be used to control gene expression.

关键词： gene control, noise strength, oscillator

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