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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi Srivastava Aparna Misra Snober S.Mir department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India department of biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2024年第1期25卷 51-64页

作者： Mingming XU Zhaoliang LIU Wenhua HU Ying HAN Zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZHANG Piliang HAO Jun XIA Shuang YANG Center for Clinical Mass Spectrometry College of Pharmaceutical SciencesSoochow UniversitySuzhou215123China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China State Key Laboratory of genetic engineering Department of BiochemistrySchool of Life SciencesFudan UniversityShanghai200438China department of Clinical Laboratory Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou310014China

Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival ***,no methods have been derived that can reliably identify early precursors of development into ***,it is urgent to discover early molecular changes during pancreatic *** aberrant glycosylation is closely associated with cancer progression,numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis;however,detailed glycoproteomic information,especially site-specific N-glycosylation changes in pancreatic cancer with and without drug treatment,needs to be further ***,we used comprehensive solid-phase chemoenzymatic glycoproteomics to analyze glycans,glycosites,and intact glycopeptides in pancreatic cancer cells and patient *** profiling of N-glycans in cancer cells revealed an increase in the secreted glycoproteins from the primary tumor of MIA PaCa-2 cells,whereas human sera,which contain many secreted glycoproteins,had significant changes of glycans at their specific *** results indicated the potential role for tumor-specific glycosylation as disease *** also found that AMG-510,a small molecule inhibitor against Kirsten rat sarcoma viral oncogene homolog(KRAS)G12C mutation,profoundly reduced the glycosylation level in MIA PaCa-2 cells,suggesting that KRAS plays a role in the cellular glycosylation process,and thus glycosylation inhibition contributes to the anti-tumor effect of AMG-510.

关键词： Pancreatic cancer Glycosylation Biomarker Glycoproteomics Mass spectrometry

Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila

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Neuroscience Bulletin 2024年第4期40卷 539-543页

作者： Xuedong Li Mengrong Wang Xiang Gao Chenyu Li Chunyu Chen Yun Qi Ying Wan Wei Yu State Key Laboratory of genetic engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai200438China School of Basic Medic Science Southwest Medical UniversityLuzhou64600China department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Dear Editor,Charcot-Marie-Tooth disease,the most common inherited peripheral neuropathology,is highly heterogeneous among patients and associated with mutations in~100 different genes at an incidence of at least 1:2,500[1].Over 30 mutated genes have been identified in CMT2,which is characterized by peripheral axon degeneration and distal deficits in motor function[2].The aminoacyl-tRNA synthetase is the largest family in CMT2 and includes tyrosyl-tRNA synthetase(YARS,tyrosyl-tRNA synthetase).

关键词： Marie degeneration pathology

Microalgae cultivation in photobioreactors: sustainable solutions for a greener future

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Green Chemical engineering 2024年第4期5卷 418-439页

作者： Shaikh Abdur Razzak Khairul Bahar K.M.Oajedul Islam Abdul Khaleel Haniffa Mohammed Omar Faruque S.M.Zakir Hossain Mohammad M.Hossain Chemical engineering department King Fahd University of Petroleum and Minerals Center for Refining and Advanced Chemicals King Fahd University of Petroleum & Minerals department of Chemical engineering University of Bahrain

Microalgae cultivation in photobioreactors（PBRs） has emerged as a promising and sustainable approach to address various environmental and energy challenges, offering a multitude of benefits across diverse *** developments in microalgae cultivation in photobioreactors have contributed substantially to the development and optimization of sustainable bioprocesses. This review presents a comprehensive analysis of recent innovations and breakthroughs in the field of microalgae cultivation, with a specific focus on their application in photobioreactors, aimed at paving the way for a greener future. This study in-depth examines the advantages of microalgae cultivation in photobioreactors, concentrating on its effectiveness in wastewater treatment, CO2bioremediation, and the production of biofuels and high-value products. The review evaluates the effects of light,solar irradiation, temperature, nitrogen and phosphorus concentrations in culture media, CO2concentrations, and pH on microalgae growth performance, including specific growth and biomass productivity. The study also examines open systems like unstirred ponds, raceway ponds, and circular ponds and closed systems like horizontal tubular, vertical bubble-column, airlift, flat panel, and plastic-bag photobioreactors, comparing their pros and cons. To optimize microalgae cultivation, key factors in photobioreactor design, including photosynthetic efficiencies, light/dark（L/D） cycles, CO2concentrations, mass transfer, hydrodynamics behavior, and p H, are extensively investigated. In addition, the review outlines recent developments in large-scale photobioreactors and highlights the challenges and opportunities associated with photobioreactor scale-up and design parameter optimization, including genetic engineering and economic feasibility. This article is a vital resource for researchers, engineers, and industry professionals seeking sustainable bioprocesses and the application of microalgae-based technol

关键词： Microalgae biomass CO 2 biofixation Wastewater treatment Biofuel Photobioreactors

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 85-94页

作者： Iffat Ara Rita Turcio Tasmia Islam Md.Sabbir Hossain Md.Kamrul Hasan department of Biochemistry and Molecular Biology Tejgaon CollegeNational UniversityGazipur-1700Bangladesh department of Pharmacy University of Naples Federico IIvia Domenico Montesano49-80131 Napoli NAItaly department of genetic engineering and biotechnology Jashore University of Science and TechnologyJashore-7408Bangladesh department of Public Health North South UniversityDhaka-1229Bangladesh

Background:Licochalcone A(LCA)is a flavonoid derived from the roots of Glycyrrhiza uralensis *** DC and other related *** natural source has been extensively used in complementary medicine,especially traditional Chinese medicine,to treat various *** as a phenolic chalcone compound,LCA has gained significant attention in recent years due to its various pharmacological ***:The objective of this review article is to assess the anti-aging ralated pharmacological properties of ***:An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA,focusing on its therapeutic applications and anti-aging-related pharmacological *** inclusion and exclusion criteria were strictly followed to retrieve updated relevant ***:A collection of 292 papers were screened,and 131 were included in this review for an in-depth analysis of Licochalcone A,focusing on its anti-aging-related pharmacological activities and relevant mechanisms,and its toxicity and side ***,the potential of LCA as a pharmacological product is discussed,emphasizing its health benefits and potential as a pharmaceutical ***:These findings indicate that Licochalcone A is a promising natural therapeutic agent for anti-aging therapy and other ailments.

关键词： Licochalcone A Glycyrrhiza uralensis Chalcone Anti-aging Neuroprotective Antioxidant Skin protection Therapeutic agent

A path planning algorithm for a crop monitoring fixed-wing unmanned aerial system

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Science China(Information Sciences) 2024年第08期67卷 5-23页

作者： Longhao QIAN Yi Lok LO Hugh Hong-tao LIU Institute of Aerospace Studies University of Toronto department of Mechanical engineering The University of Hong Kong

With the growing demand for automation in agriculture, industries increasingly rely on drones to perform crop monitoring and surveillance. In this regard, fixed-wing unmanned aerial systems(UASs)are viable platforms for scanning a large crop field, given their payload capacity and range. To achieve maximum coverage without landing for battery replacement, an algorithm for producing a minimal required energy survey path is essential. Hence, an energy-aware coverage path planning algorithm is proposed *** constraints for a fixed-wing UAS to fly at low altitudes while achieving full coverage of the crop field are first analyzed. Then, the full path is decomposed into straight-line and U-turn primitives. Finally, an algorithm to calculate a combination of straight-line segments and U-turns is proposed to obtain the path with minimum required energy consumption. The genetic algorithm is used to efficiently determine the order of the straight-line paths to traverse. Case studies show that the proposed algorithm can produce planning results for a convex-polygon-shaped crop field.

关键词： path planning genetic algorithm energy minimization fixed-wing UAS aerial survey

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Surface wave inversion with unknown number of soil layers based on a hybrid learning procedure of deep learning and genetic algorithm

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Earthquake engineering and engineering Vibration 2024年第2期23卷 345-358页

作者： Zan Zhou Thomas Man-Hoi Lok Wan-Huan Zhou department of Civil and Environmental engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina

Surface wave inversion is a key step in the application of surface waves to soil velocity ***,a common practice for the process of inversion is that the number of soil layers is assumed to be known before using heuristic search algorithms to compute the shear wave velocity profile or the number of soil layers is considered as an optimization ***,an improper selection of the number of layers may lead to an incorrect shear wave velocity *** this study,a deep learning and genetic algorithm hybrid learning procedure is proposed to perform the surface wave inversion without the need to assume the number of soil ***,a deep neural network is adapted to learn from a large number of synthetic dispersion curves for inferring the layer ***,the shear-wave velocity profile is determined by a genetic algorithm with the known layer *** applying this procedure to both simulated and real-world cases,the results indicate that the proposed method is reliable and efficient for surface wave inversion.

关键词： surface wave inversion analysis shear-wave velocity profile deep neural network genetic algorithm

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A Pan-Cancer Analysis of GAPDH as a Common Biomarker for Various Cancers

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Proceedings of Anticancer Research 2024年第5期8卷 105-120页

作者： Yasir Hameed department of biotechnology Institute of BiochemistryBiotechnologyand BioinformaticsThe Islamia University of BahawalpurPakistan

Objective:To investigate the expression levels of glyceraldehyde-3-phosphate dehydrogenase(GAPDH)and explore its prognostic value across 24 different human *** investigation was conducted using comprehensive bioinformatics and in vitro approaches,incorporating multiple layers of ***:GAPDH expression and methylation levels were assessed using bioinformatics tools and validated in cell lines through RNA-seq and targeted bisulfite-seq *** potential prognostic significance of GAPDH was evaluated using the KM ***,cBioPortal was employed to investigate genetic alterations associated with this *** analysis was conducted using ***,a correlation analysis between GAPDH expression and CD8+T immune cells was performed using TIMER and ***,a gene-drug interaction network analysis was conducted using Cytoscape to examine the relationship between GAPDH and various ***:GAPDH was found to be commonly upregulated in 24 types of human cancers,with its upregulation significantly correlated with poor relapse-free survival(RFS)and overall survival(OS)in BLCA,CESC,HNSC,KIRP,LIHC,and *** suggests that GAPDH plays a significant role in the development of these *** upregulation was also associated with various clinicopathological features in patients with BLCA,CESC,HNSC,KIRP,LIHC,and *** analysis revealed GAPDH’s involvement in diverse ***,notable correlations were observed between GAPDH expression and its promoter methylation level,genetic alterations,and CD8+T immune cell ***,several regulatory drugs targeting GAPDH were identified,with the potential to modulate its expression and potentially prevent conditions such as BLCA,CESC,HNSC,KIRP,LIHC,and ***:Based on our findings,GAPDH emerges as a promising diagnostic and prognostic biomarker for BLCA,CESC,HNSC,KIRP,LIHC,and LUAD.

关键词： Cancer Expression GAPDH Biomarker

New Antenna Array Beamforming Techniques Based on Hybrid Convolution/genetic Algorithm for 5G and Beyond Communications

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Computer Modeling in engineering & Sciences 2024年第3期138卷 2749-2767页

作者： Shimaa M.Amer Ashraf A.M.Khalaf Amr H.Hussein Salman A.Alqahtani Mostafa H.Dahshan Hossam M.Kassem Electronics and Communications engineering department Higher Institute of Engineering and TechnologyKafr ElsheikhEgypt Electronics and Electrical Communications engineering department Faculty of EngineeringMinia UniversityMiniaEgypt Electronics and Electrical Communications engineering department Faculty of EngineeringTanta UniversityTantaEgypt Electronics and Electrical Communications engineering department Faculty of EngineeringHorus University EgyptNew DamiettaEgypt department of Computer engineering College of computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia School of Computing Mathematics and EngineeringCharles Sturt UniversityBathurstNSW2795Australia

Side lobe level reduction(SLL)of antenna arrays significantly enhances the signal-to-interference ratio and improves the quality of service(QOS)in recent and future wireless communication systems starting from 5G up to ***,it improves the array gain and directivity,increasing the detection range and angular resolution of radar *** study proposes two highly efficient SLL reduction *** techniques are based on the hybridization between either the single convolution or the double convolution algorithms and the genetic algorithm(GA)to develop the Conv/GA andDConv/GA,*** convolution process determines the element’s excitations while the GA optimizes the element *** M elements linear antenna array(LAA),the convolution of the excitation coefficients vector by itself provides a new vector of excitations of length N=(2M−1).This new vector is divided into three different sets of excitations including the odd excitations,even excitations,and middle excitations of lengths M,M−1,andM,*** the same element spacing as the original LAA is used,it is noticed that the odd and even excitations provide a much lower SLL than that of the LAA but with amuch wider half-power beamwidth(HPBW).While the middle excitations give the same HPBWas the original LAA with a relatively higher *** the increased HPBWof the odd and even excitations,the element spacing is optimized using the ***,the synthesized arrays have the same HPBW as the original LAA with a two-fold reduction in the ***,for extreme SLL reduction,the DConv/GA is *** this technique,the same procedure of the aforementioned Conv/GA technique is performed on the resultant even and odd excitation *** provides a relatively wider HPBWthan the original LAA with about quad-fold reduction in the SLL.

关键词： Array synthesis convolution process genetic algorithm(GA) half power beamwidth(HPBW) linear antenna array(LAA) side lobe level(SLL) quality of service(QOS)