Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

作     者：Yuanlin Cai Ya Lv Liangzhen Shu Zhichao Jin Yonggui Robin Chi Tingting Li 

作者机构：National Key Laboratory of Green PesticideKey Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of ChemistryChemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore. 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2024年第2024卷第3期

页      面：715-721页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Key Research and Development Program of China(2022YFD1700300) the National Natural Science Foundation of China(22071036) the Program of Introducing Talents of Discipline to Universities of China(111 Program,D20023)at Guizhou University Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY(2020)004] the Guizhou Province First-Class Disciplines Project[(Yiliu Xueke Jianshe Xiangmu)-GNYL(2017)008] Guizhou University(China) Singapore National Research Foundation under its NRF Investigatorship(NRF-NRFI2016-06)and Competitive Research Program(NRF-CRP22-2019-0002) Ministry of Education,Singapore,under its MOE AcRF Tier 1 Award(RG7/20,RG70/21),MOE AcRF Tier 2(MOE2019-T2-2-117),and MOE AcRF Tier 3 Award(MOE2018-T3-1-003) a Chair Professorship Grant and Nanyang Technological University 

主　　题：chemistry aldehydes chiral 

摘      要：An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.