Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

作     者：Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi Srivastava Aparna Misra Snober S.Mir Anchal Trivedi;Adria Hasan;Rumana Ahmad;Sahabjada Siddiqui;Aditi Srivastava;Aparna Misra;Snober S.Mir

作者机构：Department of BiochemistryEra's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology LaboratoryIntegral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of BiotechnologyEra's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of BiosciencesFaculty of ScienceIntegral UniversityLucknow(226026)India 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2024年第30卷第1期

页      面：75-84页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the Office of the Dean  R&D  Integral University  for providing manuscript communication number 

主　　题：myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine 

摘      要：Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.