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World Journal of gastrointestinal surgery 2024年第7期16卷 2088-2095页

作者： Zhao-Peng Li Yan-Cheng Song Ya-Li Li Dong Guo Dong Chen Yu Li department of gastrointestinal surgery The Affiliated Hospital of Qingdao UniversityQingdao 266033Shandong ProvinceChina department of Operation room The Affiliated Hospital of Qingdao UniversityQingdao 266033Shandong ProvinceChina

BACKGROUND Bariatric surgery is one of the most effective ways to treat morbid obesity,and postoperative nausea and vomiting(PONV)is one of the common complications after bariatric *** present,the mechanism of the high incidence of PONV after weight-loss surgery has not been clearly explained,and this study aims to investigate the effect of surgical position on PONV in patients undergoing bariatric *** To explore the effect of the operative position during bariatric surgery on *** Data from obese patients,who underwent laparoscopic sleeve gastrectomy(LSG)in the authors’hospital between June 2020 and February 2022 were divided into 2 groups and retrospectively *** logistic regression analysis and the t-test were used to study the influence of operative position on *** There were 15 cases of PONV in the supine split-leg group(incidence rate,50%)and 11 in the supine group(incidence rate,36.7%)(P=0.297).The mean operative duration in the supine split-leg group was 168.23±46.24 minutes and 140.60±32.256 minutes in the supine group(Psurgery.

关键词： Postoperative nausea and vomiting Bariatric surgery Laparoscopic sleeve gastrectomy Operative positions Obesity

Impact of frailty on short-term postoperative outcomes in patients undergoing colorectal cancer surgery:A systematic review and meta-analysis

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World Journal of gastrointestinal surgery 2024年第3期16卷 893-906页

作者： Yao Zhou Xiao-Lei Zhang Hong-Xia Ni Tian-Jing Shao Ping Wang department of Operating room Affiliated Tumor Hospital of Nantong University&Nantong Tumor HospitalNantong 226361Jiangsu ProvinceChina department of gastrointestinal surgery The Affiliated Tumor Hospital of Nantong University&Nantong Tumor HospitalNantong 226361Jiangsu ProvinceChina

BACKGROUND Colorectal cancer is a major global health challenge that predominantly affects older *** management,despite advancements,requires careful consideration of preoperative patient status for optimal *** To summarize existing evidence on the association of frailty with short-term postoperative outcomes in patients undergoing colorectal cancer *** A literature search was conducted using PubMed,EMBASE and Scopus databases for observational studies in adult patients aged≥18 years undergoing planned or elective colorectal surgery for primary carcinoma and/or secondary *** studies that conducted frailty assessment using recognized frailty assess-ment tools and had a comparator group,comprising nonfrail patients,were *** effect sizes were reported as weighted mean difference or relative risk(RR)with 95%confidence intervals(CIs).RESULTS A total of 24 studies were *** with nonfrail patients,frailty was associated with an increased risk of mortality at 30 d(RR:1.99,95%CI:1.47-2.69),at 90 d(RR:4.76,95%CI:1.56-14.6)and at 1 year(RR:5.73,95%CI:2.74-12.0)of follow *** patients had an increased risk of any complications(RR:1.81,95%CI:1.57-2.10)as well as major complications(Clavien-Dindo classification grade≥III)(RR:2.87,95%CI:1.65-4.99)compared with the control *** risk of reoperation(RR:1.18,95%CI:1.07-1.31),readmission(RR:1.70,95%CI:1.36-2.12),need for blood transfusion(RR:1.67,95%CI:1.52-1.85),wound complications(RR:1.49,95%CI:1.11-1.99),delirium(RR:4.60,95%CI:2.31-9.16),risk of prolonged hospitalization(RR:2.09,95%CI:1.22-3.60)and discharge to a skilled nursing facility or rehabilitation center(RR:3.19,95%CI:2.0-5.08)was all higher in frail *** Frailty in colorectal cancer surgery patients was associated with more complications,longer hospital stays,higher reoperation risk,and increased *** frailty assessment appears crucial for tailored surgical managem

关键词： Frailty Frail adults Colorectal surgery Colorectal cancer Complications Mortality Survival Slinical outcomes Meta-analysis

Clinical efficacy and safety of double-channel anastomosis and tubular gastroesophageal anastomosis in gastrectomy

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World Journal of gastrointestinal surgery 2024年第7期16卷 2012-2022页

作者： Bei-Ying Liu Shuai Wu Yu Xu department of Operation room The Affiliated HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina department of Urology Qingdao HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266001Shangdong ProvinceChina department of gastrointestinal surgery Fujian Provincial HospitalFuzhou 350013Fujian ProvinceChina

BACKGROUND With the continuous progress of surgical technology and improvements in medical standards,the treatment of gastric cancer surgery is also *** gastrectomy is a common treatment,but double-channel anastomosis and tubular gastroesophageal anastomosis have attracted much attention in terms of surgical *** of these two surgical methods has advantages and disadvantages,so it is particularly important to compare and analyze their clinical efficacy and *** To compare the surgical safety,clinical efficacy,and safety of double-channel anastomosis and tubular gastroesophageal anastomosis in proximal *** The clinical and follow-up data of 99 patients with proximal gastric cancer who underwent proximal gastrectomy and were admitted to our hospital between January 2018 and September 2023 were included in this retrospective cohort *** to the different anastomosis methods used,the patients were divided into a double-channel anastomosis group(50 patients)and a tubular gastroesophageal anastomosis group(49 patients).In the double-channel anastomosis,Roux-en-Y anastomosis of the esophagus and jejunum was performed after proximal gastric dissection,and then side-to-side anastomosis was performed between the residual stomach and jejunum to establish an antireflux barrier and reduce postoperative gastroesophageal *** the tubular gastroesophageal anastomosis group,after the proximal end of the stomach was cut,tubular gastroplasty was performed on the distal stump of the stomach and a linear stapler was used to anastomose the posterior wall of the esophagus and the anterior wall of the stomach *** main outcome measure was quality of life 1 year after surgery in both groups,and the evaluation criteria were based on the postgastrectomy syndrome assessment *** greater the changes in body mass,food intake per meal,meal quality subscale score,and total measures of physical and mental health score,the better th

关键词： Gastric neoplasms Proximal gastrectomy Digestive tract reconstruction Dual channel reconstruction Tubular stomach reconstruction Retrospective cohort study

Prognostic factors associated with gastrointestinal dysfunction after gastrointestinal tumor surgery:A meta-analysis

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World Journal of gastrointestinal surgery 2024年第5期16卷 1420-1429页

作者： Jia Song Cong Zhou Tian Zhang department of Operating room The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjing 210031Jiangsu ProvinceChina department of gastrointestinal surgery Tongji Hospital of Huazhong University of Science and TechnologyWuhan 430073Hubei ProvinceChina department of Disinfection Supply Center The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjing 210031Jiangsu ProvinceChina

BACKGROUND Explore the risk factors of gastrointestinal dysfunction after gastrointestinal tumor surgery and to provide evidence for the prevention and intervention of gastrointestinal dysfunction in patients with gastrointestinal tumor *** To investigate the potential risk factors for gastrointestinal dysfunction following gastrointestinal tumor surgery and to present information supporting the prevention and management of gastrointestinal dysfunction in surgery *** Systematically searched the relevant literature from PubMed,Web of Science,Cochrane Library,Embase,CNKI,China Biomedical Database,Wanfang Database,and Weipu Chinese Journal Database self-established until October 1,*** Manager 5.3 software was used for meta-analysis after two researchers independently screened literature,extracted data,and evaluated the risk of bias in the included *** A total of 23 pieces of literature were included,the quality of which was medium or above,and the total sample size was *** results of meta-analysis showed that the patients were male(OR=1.58,95%CI:1.25-2.01,P=0.002)and≥60 years old(OR=2.60,95%CI:1.76-2.87,Psurgery(OR=2.90,95%CI:1.67-5.03,Pgastrointestinal dysfunction in patients with gastrointestinal *** There are many factors affecting gastroint

关键词： gastrointestinal tumor surgery Postoperative gastrointestinal dysfunction Intestinal paralysis Risk factors Metaanalysis

Occurrence and prevention of incisional hernia following laparoscopic colorectal surgery

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World Journal of gastrointestinal surgery 2024年第7期16卷 1973-1980页

作者： Xi-Wen Wu Ding-Quan Yang Ming-Wei Wang Yan Jiao The First Operating room The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina department of gastrointestinal and Colorectal surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Ministry of Health Key Laboratory of Radiobiology School of Public Health of Jilin UniversityChangchun 130000Jilin ProvinceChina department of Hepatobiliary and Pancreatic surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Among minimally invasive surgical procedures,colorectal surgery is associated with a notably higher incidence of incisional hernia(IH),ranging from 1.7% to 24.3%.This complication poses a significant burden on the healthcare system annually,necessitating urgent attention from *** a study published in the World Journal of gastrointestinal surgery,Fan et al compared the incidence of IH among 1614 patients who underwent laparoscopic colorectal surgery with different extraction site locations and evaluated the risk factors associated with its *** editorial analyzes the current risk factors for IH after laparoscopic colorectal surgery,emphasizing the impact of obesity,surgical site infection,and the choice of incision location on its ***,we summarize the currently available preventive measures for *** the low surgical repair rate and high recurrence rate associated with IH,prevention deserves greater research and attention compared to treatment.

关键词： Incisional hernia Laparoscopy Colorectal surgery Risk factor Prevention

中国胃癌肝转移患者临床诊疗特征及预后分析:全国多中心队列研究(record研究)

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Science Bulletin 2024年第3期69卷 303-307页

作者：高云鹤郗洪庆商亮唐兆庆卫勃乔治唐云王鑫鑫周静汪学非黄昌明陆俊李国新余江梁延锐季加孚李子禹薛侃梁寒柯彬臧潞何子锐谢少华黄华徐泽宽田艳涛熊建平李佶阳崔秋霞李力卢婷婷宋奇嬴刘诗贺孙益红李乐平陈凛 record研究协作组 Section of Gastric surgery Senior Department of General SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China Section of Abdominal Trauma surgery Senior Department of General SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China Institute of General surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China department of gastrointestinal surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China department of General surgery Fudan University Zhongshan HospitalShanghai 200032China department of General surgery Fujian Medical University Union HospitalFuzhou 350001China department of General surgery Nanfang Hospital Affiliated to Southern Medical UniversityGuangzhou 510515China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China department of Gastric Cancer surgery Tianjin Medical University Cancer Institute and HospitalTianjin 300060China department of General surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Population Medicine and School of Public Health Fujian Medical UniversityFuzhou 350122China department of Gastric surgery Fudan University Shanghai Cancer CenterShanghai 200032China department of General surgery Jiangsu Province HospitalNanjing Medical UniversityNanjing 210029China department of Pancreatic and Gastric surgery National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100029China

Despite surgical improvements and pharmacological advances,management of late-stage gastric cancer patients,especially those with hepatic metastasis remains challenging[1–3].Although nationwide registry data from SEER(Surveillance,Epidemiology,and End Results)[4]and the Nordic database[5]in Western countries have provided epidemiological information for patients with gastric cancer liver metastasis(GCLM),little is known about the detailed clinical characteristics.

关键词：胃癌肝转移 metastasis cancer

Establishment of predictive models and determinants of preoperative gastric retention in endoscopic retrograde cholangiopancreatography

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World Journal of gastrointestinal surgery 2024年第8期16卷 2574-2582页

作者： Ying Jia Hao-Jun Wu Tang Li Jia-Bin Liu Ling Fang Zi-Ming Liu department of Thyroid surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Division of Biliary Tract surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Division of General surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalChengdu 611730Sichuan ProvinceChina

BACKGROUND Study on influencing factors of gastric retention before endoscopic retrograde cholangiopancreatography(ERCP)background:With the wide application of ERCP,the risk of preoperative gastric retention affects the smooth progress of the *** study found that female,biliary and pancreatic malignant tumor,digestive tract obstruction and other factors are closely related to gastric retention,so the establishment of predictive model is very important to reduce the risk of *** A retrospective analysis was conducted on 190 patients admitted to our hospital for ERCP preparation between January 2020 and February *** baseline clinical data were collected using an electronic medical record *** were randomly matched in a 1:4 ratio with data from 190 patients during the same period to establish a validation group(n=38)and a modeling group(n=152).Patients in the modeling group were divided into the gastric retention group(n=52)and non-gastric retention group(n=100)based on whether gastric retention occurred *** data of patients in the validation group and identify factors influencing preoperative gastric retention in ERCP patients.A predictive model for preoperative gastric retention in ERCP patients was constructed,and calibration curves were used for *** receiver operating characteristic(ROC)curve was analyzed to evaluate the predictive value of the *** We found no statistically significant difference in general data between the validation group and modeling group(P>0.05).The comparison of age,body mass index,hypertension,and diabetes between the two groups showed no statistically significant difference(P>0.05).However,we noted statistically significant differences in gender,primary disease,jaundice,opioid use,and gastrointestinal obstruction between the two groups(P<0.05).Mul-tivariate logistic regression analysis showed that gender,primary disease,jaundice,opioid use,and gastrointestina

关键词： Cholangiopancreatography Gastric retention Influencing factors Predictive model Endoscope

Prediction model establishment and validation for enteral nutrition aspiration during hospitalization in patients with acute pancreatitis

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World Journal of gastrointestinal surgery 2024年第8期16卷 2583-2591页

作者： Ping Hou Hao-Jun Wu Tang Li Jia-Bin Liu Quan-Qing Zhao Hong-Jiang Zhao Zi-Ming Liu Division II of General surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of Hepatobiliary and Pancreatic surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina department of Thyroid surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of Oncology West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Acute pancreatitis(AP)is a disease caused by abnormal activation of pancreatic enzymes and can lead to self-digestion of pancreatic tissues and dysfunction of other *** nutrition plays a vital role in the treatment of AP because it can meet the nutritional needs of patients,promote the recovery of intestinal function,and maintain the barrier and immune functions of the ***,the risk of aspiration during enteral nutrition is high;once aspiration occurs,it may cause serious complications,such as aspiration pneumonia,and suffocation,posing a threat to the patient’s *** study aims to establish and validate a prediction model for enteral nutrition aspiration during hospitalization in patients with *** To establish and validate a predictive model for enteral nutrition aspiration during hospitalization in patients with *** A retrospective review was conducted on 200 patients with AP admitted to Chengdu Shangjin Nanfu Hospital,West China Hospital of Sichuan University from January 2020 to February *** data were collected from the electronic medical record *** were randomly divided into a validation group(n=40)and a modeling group(n=160)in a 1:4 ratio,matched with 200 patients from the same time *** modeling group was further categorized into an aspiration group(n=25)and a non-aspiration group(n=175)based on the occurrence of enteral nutrition aspiration during *** and multivariate logistic regression analyses were performed to identify factors influencing enteral nutrition aspiration in patients with AP during hospitalization.A prediction model for enteral nutrition aspiration during hospitalization was constructed,and calibration curves were used for *** operating characteristic curve analysis was conducted to evaluate the predictive value of the *** There was no statistically significant difference in general data between the validation and mode

关键词： Acute pancreatitis Hospitalization Enteral nutrition Predictive model Aspiration

Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis

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World Journal of Gastroenterology 2017年第1期23卷 110-120页

作者： Akram Yusup Bailikezi Huji Cheng Fang Fei Wang Tuerxunjiang Dadihan Hai-Jiang Wang Halmurat Upur department of gastrointestinal surgery and record room Affiliated Tumor HospitalXin Jiang Medical University department of gastrointestinal surgery Xi Jing Digestive Disease HospitalFourth Military Medical University department of Human Anatomy of Preclinical College Xinjiang Medical University Central Laboratory Xinjiang Medical University

AIM To detect the expression of trefoil factors (TFFs) and TWIST1 in colorectal cancer (CRC) and analyze their correlation with metastasis and survival. METHODS This study examined the expression of TFF1, TFF3 and TWIST1 in a total of 75 tumor samples, 47 matched normal samples (15 cm from the lesion margin), 30 metastatic lymph nodes, and 10 liver metastatic cancer samples from patients with CRC. The relationship was then analyzed between the protein expression and different clinical records. TFF1, TFF3, TWIST1, E-cadherin, vimentin and beta-catenin mRNA and protein expression levels were measured in colon cancer cell lines with different metastatic potentials (HIEC, HT29, SW620, and LoVo cells), and the correlation of the expression levels with epithelial-mesenchymal transition (EMT) was discussed. RESULTS It was found that 66.7% (50/75), 78.7% (59/75) and 54.7% (41/75) of tumor tissue samples exhibited positive staining for TFF1, TFF3 and TWIST1 and so did 27.3% (13/47), 100% (47/47) and 17% (8/47) of adjacent normal colorectal tissues. Compared with adjacent normal tissues, significant differences were found in the expression of all three proteins in different cancerous tissues (P < 0.05). Higher expression of TFF3 and TWIST1 was significantly correlated with lymph node metastasis (P = 0.034, P = 0.000), advanced stage (P = 0.031, P = 0.003), and poorer survival (P = 0.042 for the TFF3 group, P = 0.003 for the TWIST1 group). The expression of TFF3 and TWIST1 in cancer cell lines was higher than that in HIEC (a normal human intestinal epithelial cell line)(P < 0.05), and the expression intensity demonstrated a tendency to rise with increased metastatic potential both at the protein and mRNA levels. However, TFF1 expression demonstrated the opposite tendency. It was also observed that the expression of E-cadherin and beta-catenin tended to decrease while that of vimentin, TWIST1 and Snail tended to rise with the increase in metastatic potential. CONCLUSION The exp

关键词： Colorectal cancer Trefoil factors TWIST1 Survival Metastasis

中国胃癌肝转移患者临床诊疗特征及预后分析:全国多中心队列研究(record研究)（英文）

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Science Bulletin 2024年第3期 303-307页

作者：高云鹤郗洪庆商亮唐兆庆卫勃乔治唐云王鑫鑫周静汪学非黄昌明陆俊李国新余江梁延锐季加孚李子禹薛侃梁寒柯彬臧潞何子锐谢少华黄华徐泽宽田艳涛熊建平李佶阳崔秋霞李力卢婷婷宋奇嬴刘诗贺孙益红李乐平陈凛 record研究协作组 Section of Gastric surgery Senior Department of General Surgery The First Medical Center Chinese PLA General Hospital Section of Abdominal Trauma surgery Senior Department of General Surgery The First Medical Center Chinese PLA General Hospital Institute of General surgery The First Medical Center Chinese PLA General Hospital department of gastrointestinal surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University department of General surgery Fudan University Zhongshan Hospital department of General surgery Fujian Medical University Union Hospital department of General surgery Nanfang Hospital Affiliated to Southern Medical University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute department of Gastric Cancer surgery Tianjin Medical University Cancer Institute and Hospital department of General surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Institute of Population Medicine and School of Public Health Fujian Medical University department of Gastric surgery Fudan University Shanghai Cancer Center department of General surgery Jiangsu Province Hospital Nanjing Medical University department of Pancreatic and Gastric surgery National Cancer Center National Clinical Research Center for Cancer Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Despite surgical improvements and pharmacological advances,management of late-stage gastric cancer patients,especially those with hepatic metastasis remains challenging [1-3].Although nationwide registry data from SEER (Surveillance,Epidemiology,and End Results)[4] and the Nordic database [5] in Western countries have provided epidemiological information for patients with gastric cancer liver metastasis (GCLM),little is known about the detailed clinical ***,emerging evidence has indicated that selective implementation of systemic chemotherapy,immune checkpoint inhibitor (ICI) therapy,surgical resection,

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