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The Therapeutic Effect of Biling Weitong Granules Combined with Oryz-Aspergillus Enzyme and Pancreatin Tablet on Reflux Esophagitis with Functional Dyspepsia

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Proceedings of Anticancer Research 2024年第2期8卷 46-52页

作者： Yalan Chen Ruiyao Wang Na Zhao Jie Liang department of gastroenterology The Affiliated Hospital of Hebei UniversityBaoding 071000China department of Thoracic Surgery The Affiliated Hospital of Hebei UniversityBaoding 071000China endoscopy Center Department of GastroenterologyThe Affiliated Hospital of Hebei UniversityBaoding 071000China

Objective:To investigate the therapeutic effect of Biling Weitong Granules combined with oryz-aspergillus enzyme and pancreatin tablets on patients with reflux esophagitis with functional ***:Sixty patients diagnosed with reflux esophagitis with functional dyspepsia who were admitted to the Affiliated hospital of Hebei University between June 2020 and June 2023 were selected and divided into two groups:the control group and the observation group,each consisting of 30 *** control group received oryz-aspergillus enzyme and pancreatin tablets only,while the observation group received Biling Weitong Granules in addition to the *** clinical efficacy,Chinese medicine syndrome points,esophageal kinetic indexes,gastrointestinal hormone levels,and therapeutic safety of both groups were ***:The total efficiency of the observation group reached 93.33%,significantly higher than the 73.33%of the control group(P0.05).Conclusion:The combination of Biling Weitong Granules with oryz-aspergillus enzyme and pancreatin tablets demonstrates significant efficacy in the treatment of reflux esophagitis with functional dyspepsia,wi

关键词： Biling Weitong Granules Oryz-aspergillus enzyme and pancreatin tablets Reflux esophagitis Functional dyspepsia

CO_2 insufflation for potentially diffi cult colonoscopies: Effi cacy when used by less experienced colonoscopists

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World Journal of gastroenterology 2009年第41期15卷 5186-5192页

作者： Toshio Uraoka Jun Kato Motoaki Kuriyama Keisuke Hori Shin Ishikawa Keita Harada Koji Takemoto Sakiko Hiraoka Hideyuki Fujita Joichiro Horii Yutaka Saito Kazuhide Yamamoto department of endoscopy Okayama University Hospital department of gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Division of endoscopy National Cancer Center Hospital

AIM： To clarify the effectiveness of CO2 insufflation in potentially difficult colonoscopy cases, particularly in relation to the experience level of colonoscopists. METHODS： One hundred twenty potentially difficult cases were included in this study, which involved females with a low body mass index and patients with earlier abdominal and/or pelvic open surgery or previously diagnosed left-side colon diverticulosis. Patients receiving colonoscopy examinations without sedation using a pediatric variable-stiffness colonoscope were divided into two groups based on either CO2 or standard air insuffiation. Both insufflation procedures were also evaluated according to the experience level of the respective colonoscopists who were divided into an experienced colonoscopist （EC） group and a less experienced colonoscopist （LEC） group. Study measurements included a 100-mm visual analogue scale （VAS） for patient pain during and after colonoscopy examinations, in addition to insertion to the cecum and withdrawal times. RESULTS： Examination times did not differ, however, VAS scores in the CO2 group were significantly better than in the air group （P〈 0.001, two-way ANOVA） from immediately after the procedure and up to 2 h later. There were no significant differences between either insufflation method in the EC group （P = 0.29）, however, VAS scores for CO2 insufflation were significantly better than air insufflation in the LEC group （P = 0.023） immediately after colonoscopies and up to 4 h afterwards. CONCLUSION： CO2 insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs.

关键词： CO2 insufflation Colonoscopy Difficult colonoscopy Experienced colonoscopist Training

Balloon overtube-guided colorectal endoscopic submucosal dissection

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World Journal of gastroenterology 2009年第48期15卷 6086-6090页

作者： Tomohiko Ohya Ken Ohata Kazuki Sumiyama Yousuke Tsuji Ikuro Koba Nobuyuki Matsuhashi Hisao Tajiri department of endoscopy The Jikei University School of Medicine Division of gastroenterology Kanto Medical Center NTT EC Division of gastroenterology and Hepatology Yamaga Chou Hospital department of endoscopy Department of Gastroenterology and HepatologyThe Jikei University School of Medicine

AIM:To evaluate the usefulness of a balloon overtube to assist colorectal endoscopic submucosal dissection(ESD)using a ***:The results of 45 consecutive patients who underwent colorectal ESD were analyzed in a single tertiary endoscopy *** preoperative evaluation of access to the lesion,difficulties were experienced in the positioning and stabilization of a gastroscope in 15 patients who were thus assigned to the balloonguided ESD group.A balloon overtube was placed with a gastroscope to provide an endoscopic channel to the lesion in cases with preoperatively identified difficulties related to *** ESD was performed following standard procedures.A submucosal fluid bleb was created with hyaluronic acid solution.A circumferential mucosal incision was made to marginate the *** isolated lesion was finally excised from the deeper layers with repetitive electrosurgical dissections with needle *** success of colorectal ESD,procedural feasibility,and procedure-related complications were the main outcomes and ***:The overall en bloc excision rate of colorectal ESD during this study at our institution was 95.6%.En bloc excision of the lesion was successfully achieved in 13 of the 15 patients(86.7%)in the balloon overtube-guided colorectal ESD group,which was comparable to the results of the standard ESD group with better accessibility to the lesion(30/30,100%,not statistically significant).CONCLUSION:Use of a balloon overtube can improve access to the lesion and facilitate scope manipulation for colorectal ESD.

关键词： Balloon overtube Colorectal neoplasm Early colorectal cancer En bloc tumor excision Endoscopic submucosal dissection Laterally spreading tumor

Impairment of secondary peristalsis in Barrett's esophagus by transnasal endoscopy-based testing

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World Journal of gastroenterology 2014年第3期20卷 822-828页

作者： Go Kobayashi Mitsuru Kaise Hiroshi Arakawa Hisao Tajiri department of gastroenterology and Hepatology Jikei University Daisan Hospital department of gastroenterology Toranomon Hospital department of endoscopy Jikei University Kashiwa Hospital department of gastroenterology and Hepatology Jikei University School of Medicine

AIM: To investigate dysfunctions in esophageal peristalsis and sensation in patients with Barrett’s esophagus following acid infusion using endoscopy-based testing.

关键词： Barrett’ s esophagus, Transnasal endoscopy, Acid infusion test, Esophageal sensation, Secondary peristalsis

Usefulness of a novel slim type Flush Knife-BT over conventional Flush Knife-BT in esophageal endoscopic submucosal dissection

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World Journal of gastroenterology 2017年第9期23卷 1657-1665页

作者： Yoshiko Ohara Takashi Toyonaga Namiko Hoshi Shinwa Tanaka Shinichi Baba Hiroshi Takihara Fumiaki Kawara Tsukasa Ishida Yoshinori Morita Eiji Umegaki Takeshi Azuma Division of gastroenterology Department of Internal MedicineGraduate School of MedicineKobe University department of endoscopy Kobe University Hospital department of endoscopy Kishiwada Tokushukai Hospital

To investigated the usefulness of a novel slim type ball-tipped FlushKnife (FlushKnife-BTS) over ball-tipped FlushKnife (FlushKnife-BT) in functional experiments and clinical *** order to evaluate the functionality of FlushKnife-BTS, water aspiration speed, resistance to knife insertion through the scope, and waterjet flushing speed were compared between FlushKnife-BTS and BT. In clinical practice, esophageal endoscopic submucosal dissection (ESD) performed using FlushKnife-BTS or BT by an experienced endoscopist between October 2015 and January 2016 were retrospectively reviewed. The treatment speed and frequency of removing and reinserting the knife to aspirate fluid and air during ESD sessions were *** experiments revealed that water aspiration speed by the endoscope equipped with a 2.8-mm working channel with FlushKnife-BTS was 7.7-fold faster than that with conventional FlushKnife-BT. Resistance to knife insertion inside the scope with a 2.8-mm working channel was reduced by 40% with FlushKnife-BTS. The waterjet flushing speed was faster with the use of FlushKnife-BT. In clinical practice, a comparison of 6 and 7 ESD using FlushKnife-BT and BTS, respectively, revealed that the median treatment speed was 25.5 mm2/min (range 19.6-30.3) in the BT group and 44.2 mm2/min (range 15.5-55.4) in the BTS group (P = 0.0633). However, the median treatment speed was significantly faster with FlushKnife-BTS when the resection size was larger than 1000 m2 (n = 4, median 24.2 mm2/min, range 19.6-27.7 vs n = 4, median 47.4 mm2/min, range 44.2-55.4, P = 0.0209). The frequency of knife replacement was less in the BTS group (median 1.76 times in one hour, range 0-5.45) than in the BT group (7.02 times in one hour, range 4.23-15) (P = 0.0065).CONCLUSIONOur results indicate that FlushKnife-BTS enhances the performance of ESD, particularly for large lesions, by improving air and fluid aspirat

关键词： Endoscopic submucosal dissection Novel slim type ball-tipped FlushKnife Ball-tipped FlushKnife Resistance to knife insertion Water aspiration speed

Endoscopic resection for early gastric cancer:Towards a global understanding

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World Journal of gastroenterology 2022年第13期28卷 1377-1379页

作者： Alba Panarese department of gastroenterology and Digestive endoscopy Central HospitalTaranto 74123Italy

Gastric cancer is widespread globally,and disease diagnosis is accompanied by high mortality and morbidity ***,prognoses and survivability have improved following implementation of surveillance and screening programs,which have led to earlier ***,early diagnosis itself supports increased surgical curability,which is the main treatment goal and guides therapeutic *** most recent Japanese guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer consider the degree of endoscopic curability in relation to the characteristics of the gastric *** clinical practice,the management approach for both prevention and treatment should be similar to that of colon lesions;however,unlike the established practices for colorectal cancer,the diagnostic and therapeutic pathways are not shared nor widespread for gastric ***,this negatively impacts the opportunity to perform an endoscopic resection with curative intent.

关键词： Early gastric cancer Artificial intelligence Malignancy Helicobacter pylori Autoimmune gastritis Dysplasia

Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians:A United States national experience

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World Journal of Gastrointestinal endoscopy 2024年第3期16卷 148-156页

作者： Sanket Dhirubhai Basida Dushyant Singh Dahiya Muhammad Nadeem Yousaf Brinda Basida Bhanu Siva Mohan Pinnam Manesh Kumar Gangwani Hassam Ali Sahib Singh Yash R Shah Daksh Ahluwalia Mihir Prakash Shah Saurabh Chandan Neil R Sharma Shyam Thakkar department of Internal Medicine University of Missouri-ColumbiaColumbiaMO 65212United States Division of gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Division of gastroenterology and Hepatology University of MissouriColumbiaMO 65212United States department of Rheumatology Medical College of GeorgiaAugusta UniversityNorth AugustaGA 30912United States department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States department of Internal Medicine The University of ToledoToledoOH 43606United States Division of gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Interventional Oncology&Surgical endoscopy GI Oncology Tumor Site TeamParkview Cancer InstituteParkview HealthFort WayneIN 46845United States Section of gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an essential therapeutic tool for biliary and pancreatic *** and elderly patients,especially those aged≥90 years are generally considered a higher-risk population for ERCP-related *** To investigate outcomes of ERCP in the Non-agenarian population(≥90 years)concerning *** This is a cohort study using the 2018-2020 National Readmission *** aged≥90 were identified who underwent ERCP,using the international classification of diseases-10 code with clinical *** Hopkins’s adjusted clinical groups frailty indicator was used to classify patients as frail and *** primary outcome was mortality,and the secondary outcomes were morbidity and the 30 d readmission rate related to *** used univariate and multivariate regression models for *** A total of 9448 patients were admitted for any indications of *** and non-frail patients were 3445(36.46%)and 6003(63.53%)*** for ERCP were Choledocholithiasis(74.84%),Biliary pancreatitis(9.19%),Pancreatico-biliary cancer(7.6%),Biliary stricture(4.84%),and Cholangitis(1.51%).Mortality rates were higher in frail group[adjusted odds ratio(aOR)=1.68,P=0.02].The Intra-procedural complications were insigni-ficant between the two groups which included bleeding(aOR=0.72,P=0.67),accidental punctures/lacerations(aOR=0.77,P=0.5),and mechanical ventilation rates(aOR=1.19,P=0.6).Post-ERCP complication rate was similar for bleeding(aOR=0.72,P=0.41)and post-ERCP pancreatitis(aOR=1.4,P=0.44).Frail patients had a longer length of stay(6.7 d vs 5.5 d)and higher mean total charges of hospitalization($78807 vs$71392)compared to controls(P<0.001).The 30 d all-cause readmission rates between frail and non-frail patients were similar(P=0.96).CONCLUSION There was a significantly higher mortality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared

关键词： Endoscopic retrograde cholangiopancreatography Nonagenarians Frailty Mortality Healthcare burden

Efficacy of forced coagulation with low high-frequency power setting during endoscopic submucosal dissection

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World Journal of gastroenterology 2017年第29期23卷 5422-5430页

作者： Tsukasa Ishida Takashi Toyonaga Yoshiko Ohara Tadao Nakashige Yasuaki Kitamura Ryusuke Ariyoshi Hiroshi Takihara Shinichi Baba Tetsuya Yoshizaki Fumiaki Kawara Shinwa Tanaka Yoshinori Morita Eiji Umegaki Namiko Hoshi Takeshi Azuma Division of gastroenterology Department of Internal Medicine Graduate School of Medicine Kobe University department of endoscopy Kobe University Hospital department of endoscopy Kishiwada Tokushukai Hospital

To investigated the hemostatic ability of the S and F1-10 methods in clinical and ex vivo studies. METHODSThe hemostatic abilities of the two methods were analyzed retrospectively in all six gastric endoscopic submucosal dissection cases. The treated vessel diameter, compressed vessel frequency, and bleeding frequency after cutting the vessels were noted by the recorded videos. The coagulation mechanism of the two power settings was evaluated using the data recording program and histological examination on macro- and microscopic levels in the ex vivo experiments using porcine tissues. RESULTSF1-10 method showed a significantly better hemostatic ability for vessels ≥ 2 mm in diameter and a trend of overall better coagulation effect, evaluated by the bleeding rate after cutting the vessels. F1-10 method could sustain electrical current longer and effectively coagulate the tissue wider and deeper than the S method in the porcine model. CONCLUSIONF1-10 method is suggested to achieve a stronger hemostatic effect than the S method in clinical procedures and ex vivo models.

关键词： Endoscopic submucosal dissection Electrosurgery Endoknife Hemostatic effect The forced coagulation mode

Wireless capsule endoscopy: Perspectives beyond gastrointestinal bleeding

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World Journal of gastroenterology 2014年第42期20卷 15664-15673页

作者： Eduardo Redondo-Cerezo Antonio Damián Sánchez-Capilla Paloma De La Torre-Rubio Javier De Teresa endoscopy Unit Department of Gastroenterology University Hospital Virgen de Las Nieves department of gastroenterology University Hospital Virgen de Las Nieves

Wireless capsule endoscopy(CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal(GI) bleeding. Over subsequent years, this technology has been refined to provide superior resolution, increased battery life, and capabilities to view different parts of the GI tract. Indeed, cases for which CE proved useful have increased significantly over the last few years, with new indications for the small bowel and technical improvements that have expanded its use to other parts of the GI tract, including the esophagus and colon. The main challenges in the development of CE are new devices with the ability to provide therapy, air inflation for a better vision of the small bowel, biopsy sampling systems attached to the capsule and the possibility to guide and move the capsule with an external motion control. In this article we review the current and new indications of CE, and the evolving technological changes shaping this technology, which has a promising potential in the coming future of gastroenterology.

关键词： Wireless capsule endoscopy Obscure gastrointestinal bleeding Small bowel tumors Colon capsule endoscopy Esophageal capsule endoscopy