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science China Life sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine department of Urology The Second Affiliated HospitalZhejiang University School of Medicine department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Determination of Electrical Conductivity of Cadaver Skeletal Muscle: A Promising Method for the Estimation of Late Postmortem Interval

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Journal of forensic science and medicine 2015年第1期1卷 16-20页

作者： Zhiyuan Xia Xiandun Zhai Beibei Liu Yaonan Mo department of forensic medicine Forensic Medicine InstituteHenan University of Science and TechnologyHenanChina

The electrical conductivity(EC)of extracted muscle fluid has been extensively used to evaluate meat freshness and shelf life in the field of food sanitation for *** opposite of freshness is the corruption that increases with *** on the freshness/corruption principle,we investigated the relationship between long postmortem intervals(PMIs)and EC in cadaver skeletal *** values of extracted fluid from rat muscles were measured at different PMIs for 10 *** results indicate that there was a significant correlation between PMI and EC,and the data fit well to the cubic polynomial regression equation y=‑0.01x3+0.264x2‑13.657x+1769.148(R2=0.925).In addition,the EC of different dilutions of these muscle extracts showed strict quadratic correlation(R2=1)with the dilution ratios,suggesting that EC can be measured with very small quantities of muscle *** study suggests that determination of the EC of cadaver skeletal muscle extracts may be a useful method for estimating long PMIs.

关键词： Electrical conductivity forensic science muscle extraction liquid muscle fluid extract postmortem interval estimation

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Aviation medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Emergency medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Cognitive control subprocess deficits and compensatory modulation mechanisms in patients with frontal lobe injury revealed by EEG markers:a basic study to guide brain stimulation

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General Psychiatry 2023年第4期36卷 260-272页

作者： Sinan Liu Chaoqun Shi Huanhuan Meng Yu Meng Xin Gong Xiping Chen Luyang Tao department of forensic medicine School of Basic Medicine and Biological SciencesAffiliated Guangji HospitalSoochow UniversitySuzhouJiangsuChina department of forensic medicine Institute of Forensic Medicine and Laboratory MedicineJining Medical UniversityJiningShandongChina department of Pathology Forensic and Pathology LaboratoryInstitute of Forensic ScienceJiaxing UniversityJiaxingZhejiangChina

Background Frontal lobe injury(FLI)is related to cognitive control impairments,but the influences of FLI on the internal subprocesses of cognitive control remain *** We sought to identify specific biomarkers for long-term dysfunction or compensatory modulation in different cognitive control *** A retrospective case-control study was ***-related potentials(ERP),oscillations and functional connectivity were used to analyse electroencephalography(EEG)data from 12 patients with unilateral frontal lobe injury(UFLI),12 patients with bilateral frontal lobe injury(BFLI)and 26 healthy controls(HCs)during a Go/NoGo task,which included several subprocesses:perceptual processing,anticipatory preparation,conflict monitoring and response *** Compared with the HC group,N2(the second negative peak in the averaged ERP waveform)latency,and frontal and parietal oscillations were decreased only in the BFLI group,whereas P3(the third positive peak in the averaged ERP waveform)amplitudes and sensorimotor oscillations were decreased in both patient *** functional connectivity of the four subprocesses was as follows:alpha connections of posterior networks in the BFLI group were lower than in the HC and UFLI groups,and these alpha connections were negatively correlated with neuropsychological *** connections of the dorsal frontoparietal network in the bilateral hemispheres of the BFLI group were lower than in the HC and UFLI groups,and these connections in the uninjured hemisphere of the UFLI group were higher than in the HC group,which were negatively correlated with behavioural *** and theta connections of the midfrontal-related networks in the BFLI group were lower than in the HC *** across-network connections in the HC group were higher than in the BFLI group but lower than in the UFLI *** The enhancement of low-frequency connections reflects compensatory *** contrast,alpha c

关键词： connectivity EEG network

Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen Huang Stephen Temitayo Bello department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael S.Wolfe Computational medicine Program and department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Determining the Electrical Conductivity of Rat Cadaveric Liver,Spleen,and Kidney to Estimate Early Postmortem Interval

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Journal of forensic science and medicine 2017年第3期3卷 111-114页

作者： Zhe Zheng Xiandun Zhai Zhiyuan Xia Yaonan Mo department of forensic medicine Forensic Medicine SchoolHenan University of Science and TechnologyLuoyangHenanChina

Previous research has found that electrical conductivity(EC),an important index to predict meat freshness and shelflife,is very promising for estimating the late postmortem interval(PMI).However,whether it has potential use in the early PMI has not been fully studied *** test this possibility in the present study,EC of three internal organs of rat liver,spleen,and kidney were determined within 24 postmortem hows,and then,EC changes at different PMIs were carefully *** overall results showed that EC of liver and spleen increased significantly with PMI while EC of kidney had minor changes during the same ***,significant linear positive correlations between EC of liver and spleen and PMI were found and the coefficients of their regression functions were R^(2)=0.98 and R^(2)=0.95,*** can be concluded that determination of EC in certain internal organs such as liver and spleen may be a potential tool in the early PMI ***,more researches on its influencing factors are needed to facilitate its final use in practice.

关键词： Early postmortem interval electrical conductivity forensic science kidney liver spleen

Multi-locus identification of Psilocybe cubensis by high-resolution melting(HRM)

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forensic sciences Research 2022年第3期7卷 490-497页

作者： Xiaochun Zhang Huan Yu Ziwei Wang Qi Yang Ruocheng Xia Yiling Qu Ruiyang Tao Yan Shi Ping Xiang Suhua Zhang Chengtao Li department of forensic science Medical School of Soochow UniversitySuzhouChina Shanghai Key Laboratory of forensic medicine Shanghai Forensic Service PlatformAcademy of Forensic SciencesMinistry of JusticeShanghaiChina department of forensic medicine School of Basic Medical ScienceWenzhou Medical UniversityWenzhouChina Institute of forensic medicine West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengduChina

Hallucinogenic mushroom is a kind of toxic strain containing psychoactive tryptamine substances such as psilocybin,psilocin and ibotenic acid,*** mushrooms containing hallucinogenic components are various,widely distributed and lack of standard to define,which made a great challenge to *** identification methods,such as morphology and toxicology analysis,showed shortcomings in old or processed samples,while the DNA-based identification of hallucinogenic mushrooms would allow to identify these samples due to the stability of *** this paper,four primer sets are designed to target Psilocybe cubensis DNA for increasing resolution of present identification method,and the target markers include largest subunit of RNA polymerase II(marked as PC-R1),psilocybin-related phosphotransferase gene(marked as PC-PT),glyceraldehyde 3-phosphate dehydrogenase(marked as PC-3)and translation EF1α(marked as PC-EF).Real-time PCR with high-resolution melting(HRM)assay were used for the differentiation of the fragments amplified by these primer sets,which were tested for specificity,reproducibility,sensitivity,mixture analysis and multiplex *** was shown that the melting temperatures of PC-R1,PC-PT,PC-3 and PC-EF of *** were(87.93±0.12)℃,(82.21±0.14)℃,(79.72±0.12)℃ and(80.11±0.19)℃ in our kinds of independent *** HRM characteristic can be shown with a low concentration of 62.5pg/µL DNA sample,and *** could be detected in mixtures with Homo sapiens or Cannabis *** summary,the method of HRM analysis can quickly and specifically distinguish *** from other species,which could be utilized for forensic science,medical diagnosis and drug trafficking cases.

关键词： forensic sciences forensic genetics polymerase chain reaction(PCR) high-resolution melting(HRM) Psilocybe cubensis multi-locus species-specific

Development of forensic standards in China: a review

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forensic sciences Research 2022年第1期7卷 1-10页

作者： Xiaodan He Chengtao Li Shanghai Key Laboratory of forensic medicine Key Laboratory of Forensic ScienceAcademy of Forensic ScienceMinistry of JusticeShanghaiChina

forensic science is crucial for the administration of justice and case *** China,political-legal organizations,including the courts,public security,procuratorate,and judicial administration,developed their own forensic practices before *** a result,the frequent and repeated appraisals undermined judicial authority and ***,a law was published in 2005 to improve the uniform forensic management system by the Standing Committee of the National People’s Congress,leading to the establishment of the forensic Administration of the Ministry of Justice in *** this process,the increased accreditation and interflow highlighted the role of consensus in forensic standards for forensic service providers to avoid uncertainty regarding the methods used and interpretation of *** 2017,a policy document was promulgated again to strengthen the importance of the uniform standards,which also proposed to establish a new national technical committee for the standardization of forensic science by the General Office of the State *** 2018,despite the continuing problems concerning uniformity,the forensic Administration of the Ministry of Justice was merged into the Public Legal Services ***,there is still a long way to go for the national technical committee for the standardization of forensic *** paper analyses the evolution of forensic standards internationally and nationally,discusses the existing problems,and proposes relative ***,it discusses the future of standards development with the deepening of the reformation of both the national standardization and judicial system.

关键词： forensic sciences standards accreditation technical committee reform

How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia Annalisa Nobili department of medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly department of science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine